Recurrent Histiocytic Necrotizing Lymphadenitis (Kikuchi's Disease) in an Human T Lymphotropic Virus Type I Carrier.

Abstract

Wedescribe a case of recurrent histiocytic necrotizing lymphadenitis (HNL) with aseptic meningitis. The patient was a 46-year-old male and a carrier of humanT lymphotropic virus type I (HTLV-I). The patient had a past medical history of at least three relapses of HNL. In addition, his sister, whowas also an HTLV-Icarrier, had recurrent clinical episodes consistent with those ofHNL, suggesting familial HNLoccurrence. This observation suggests the possibility that HTLV-I infection is relevant to the pathogenesis of HNL. (Internal Medicine 35: 821-825, 1996)

Kikuchi-Fujimoto disease: lymphadenopathy in siblings

“…4,[7][8][9] Human leukocyte antigen (HLA) genotyping for familial Kikuchi-Fujimoto disease has been reported in only one paper. 4 The sisters described in that case share some HLA genotypes as the sisters described here; both of our patients tested positive for HLA-Cw7 and the older sister (Patient 1) also tested positive for HLA-B35.…”

Linfadenitis necrotizante histiocitaria: Comunicación de 3 casos

“…Otra hipótesis sugiere como patogenia una respuesta inmune desproporcionada contra autoantígenos expresados en células apoptóticas de pacientes genéticamente susceptibles 38 . Una agregación familiar podría explicar la hermana con EKF en el tercer caso y al mismo tiempo sustentar la hipótesis anteriormente mencionada, sin embargo, existen escasos casos reportados al respecto [39][40][41][42] y solamente en dos estudios los pacientes compartían genotipos del sistema mayor de histocompatibilidad humana 39,40 , desconociéndose si cumplen algún rol.…”

Concurrent Development of Spontaneous Pyomyositis Due to Staphylococcus Epidermidis and Kikuchi-Fujimoto Disease

“…Kikuchi (6) and Fujimoto (7), both from Japan. The cause of KFD is unknown, but various infectious etiologies have been suggested (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) T a b l e 1 . Va r i a t i o n o f He ma t o l o g i c a l P a r a me t e r s a n d C-r e a c t i v e P r o t e i n d u r i n g Ant i b i o t i c a n d Co r t i c o s t e r o i d T r e a t me n t i n t h e P r e s e n t Ca s e o f Co n c u r r e n t De v e l o pme n t o f S p o n t a n e o u s P y o my o s i t i s a n d Ki k u c h i -F u j i mo (19).…”

“…Apoptotic lymphocyte death has been implicated in mesenteric necrotizing lymphadenitis caused by Rickettsia tsutsugamushi, which, histologically, is quite similar to KFD lymphadenitis (33). (8,9), parainfluenza virus (10), HTLV-1 (11), and HIV (12) (25) or drive them to proliferate via stimulation of cytokine production (26). Cervical (4) and generalized lymphadenopathy (27) (34), which is characterized by early immune dysfunction predisposing to unusual infections (35).…”

“…Cervical (4) and generalized lymphadenopathy (27) (34), which is characterized by early immune dysfunction predisposing to unusual infections (35). KFD has also been described in association with HTLV-1 infection (11), while it is increasingly reported in HIV infected patients (12), in whom infections, including pyomyositis (36), may occur without an apparent immune disorder (37 …”