Kikuchi-Fujimoto disease: lymphadenopathy in siblings

Stasiuk, Allison; Teschke, Susan; Williams, G. J.; Seftel, Matthew D.

doi:10.1503/cmaj.091347

Cited by 14 publications

(24 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2 In one report 1 KFD was documented in two human leucocyte antigen (HLA) identical non-twin sisters living in same environment, presenting two years apart at same age with cervical lymphadenopathy, poor dental hygiene and periodontal disease 1 …”

Section: Discussionmentioning

confidence: 99%

“…Familial occurrence of KFD has been reported rarely in literature. 1,2 We describe familial occurrence of KFD in two siblings.…”

Section: Introductionmentioning

confidence: 98%

“…Most patients are young adults, but the disease can occur at any age. There is female predilection with male: female ratio ranging from 1:3 to 1:4 1 . Familial occurrence of KFD has been reported rarely in literature.…”

Section: Introductionmentioning

confidence: 99%

“…Though no specific treatment is available for KFD, non-steroidal anti-inflammatory drugs, corticosteroids and IV immunoglobulin have all been used; The recurrence rate ranges from 3%-4%. 1,2,11 The diagnosis of KFD should be considered in the differential diagnosis in young females of Asian origin presenting with fever and cervical lymphadenopathy. Histopathology of lymph nodes help in confirming the diagnosis.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Familial Kikuchi-Fujimoto disease

Krishnappa

et al. 2015

J Clin Sci Res

View full text Add to dashboard Cite

Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disease of unknown aetiology presenting with cervical lymphadenopathy, fever, vomiting, weight loss, night sweats and chills. Familial occurrence of KFD is reported very rarely in literature. We report two cases from the same family presenting with KFD. The two non-twin sisters presented with symptoms of fever, cervical lymphadenopathy, weight loss, nausea, vomiting, night sweats and chills 6 months apart. The elder sibling with KFD also manifested mononeuritis multiplex. Laboratory evaluation revealed raised erythrocyte sedimentation rate, C-reactive protein levels and leucopenia. Anti-nuclear antibody and anti-double stranded deoxyribonucleic acid antibody were negative. Histopathological findings were suggestive of Kikuchi -Fujimoto's disease. The patients responded well to oral corticosteroid treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Familial occurrence of KFD has been reported rarely in literature. 1,2 We describe familial occurrence of KFD in two siblings.…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Familial Kikuchi-Fujimoto disease

Krishnappa

et al. 2015

J Clin Sci Res

View full text Add to dashboard Cite

show abstract

“…Otra hipótesis sugiere como patogenia una respuesta inmune desproporcionada contra autoantígenos expresados en células apoptóticas de pacientes genéticamente susceptibles 38 . Una agregación familiar podría explicar la hermana con EKF en el tercer caso y al mismo tiempo sustentar la hipótesis anteriormente mencionada, sin embargo, existen escasos casos reportados al respecto [39][40][41][42] y solamente en dos estudios los pacientes compartían genotipos del sistema mayor de histocompatibilidad humana 39,40 , desconociéndose si cumplen algún rol.…”

Section: Discussionunclassified