The Severe acute respiratory syndrome may be caused by coronavirus disease which has resulted in a global pandemic. Polymorphisms in the population play a role in susceptibility to severity. We aimed to perform a systematic review related to the effect of single nucleotide polymorphisms in the development of severe acute respiratory syndrome (SARS). Twenty-eight eligible articles published were identified in PubMed, ScienceDirect, Web of Science, PMC Central and Portal BVS and additional records, with 20 studies performed in China. Information on study characteristics, genetic polymorphisms, and comorbidities was extracted. Study quality was assessed by the STrengthening the REporting of Genetic Association (STREGA) guideline. Few studies investigated the presence of polymorphisms in HLA, ACE1, OAS-1, MxA, PKR, MBL, E-CR1, FcγRIIA, MBL2, L-SIGN (CLEC4M), IFNG, CD14, ICAM3, RANTES, IL-12 RB1, TNFA, CXCL10/IP-10, CD209 (DC-SIGN), AHSG, CYP4F3 and CCL2 with the susceptibility or protection to SARS-Cov. This review provides comprehensive evidence of the association between genetic polymorphisms and susceptibility or protection to severity SARS-CoV. The literature about coronavirus infection, susceptibility to severe acute respiratory syndrome (SARS) and genetic variations is scarce. Further studies are necessary to provide more concrete evidence, mainly related to Covid-19.

This meta-analysis showed that TNF-α (-308) polymorphism is associated with dengue symptomatic susceptibility.

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Objetivo: identificar as evidências científicas sobre perfil relacionado à saúde mental em pessoas após a aquisição da infecção pelo coronavírus, bem como elucidar a influência na saúde mental dos profissionais de saúde. Métodos: a revisão integrativa utilizou-se das bases de dados PubMed, Science direct e PMC Central, usando os descritores “covid”, “coronavirus”, “transtornos mentais” e “risco de suicídio” e seus correspondentes em inglês junto aos operadores booleanos “AND” e “OR”. Resultados: treze estudos foram incluídos nesta pesquisa, posteriormente a aplicação dos critérios de inclusão. A maioria dos estudos envolveu a metodologia transversal e, entre as síndromes respiratórias investigadas, a maioria realizou o estudo avaliando o coronavírus (COVID-19) (n=5), e cinco estudaram a síndrome respiratória aguda grave (SARS – Cov) (n=5). Apenas três estudos investigaram o perfil de saúde mental em profissionais de saúde. Transtorno de estresse pós-traumático (TEPT), depressão, ansiedade, distúrbios do sono e risco de suicídio. Conclusão: o impacto causado pela proliferação rápida e repentina da infecção pelo coronavírus promove o medo, a insegurança e o desenvolvimento com transtornos mentais em pacientes com coronavírus. Entretanto,

This research identifies the association of the IFNG (+874 A/T), TNFA (-308G/A), IL-10 (-819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue.

Objective: This study sought to identify the presence of HPV infection and the risk factors related to susceptibility to cervical cancer in asymptomatic women. Methods: It is a cross-sectional study with 428 users attended Basic Health Units, in Arapiraca, Alagoas, Brazil. Sociodemographic, behavioral variables, and cytopathological reports were collected. Molecular detection of the HPV virus was performed by Nested-PCR. Statistical analysis was conducted with SPSS version 22.0. Results: A total of 428 women were studied, HPV DNA detected in 39.2% (n = 168), with a mean age of 41 years old. There was an association of HPV with use of oral contraceptives (p <0.016) and alcoholism (p <0.038). It was showed a higher frequency of positive HPV in women older than 25 years old (88.7%), up to 5 sexual partners (93.4%), up to 3 pregnancies (71.4%), and with the cytopathologic results within the limits of normality (61.9%). HPV was identified in 40.3% (104/258) of the women with results within the limits of normality. Conclusion: Our results suggest that the use of oral contraceptives and alcoholism may be considered as possible risk factors related to cervical oncogenesis. With this, it is necessary to propose interventions aimed at the health education of this population, actions of prevention, and early detection.

RESUMO:A educação em saúde representa a formação de atitudes e valores que levam a sociedade ao comportamento inteligente, contribuindo para o benefício de sua saúde e da saúde dos outros, a exemplo da educação em saúde. As atividades de educação em saúde estão inseridas entre os compromissos dos profissionais de saúde, sendo perceptível que tais profissionais possuam um caráter informativo, repassando e explicando hábitos e comportamentos saudáveis, onde a disseminação dessas informações, geralmente são realizadas por meio de campanhas e publicadas pelos meios de comunicação em massa a toda à população. Esse estudo teve como objetivo compreender um pouco da história da educação em saúde e a sua importância para a sociedade. A pesquisa para a construção da revisão bibliográfica foi realizada através de livros e portal de dados. Os resultados mostraram que a eficácia da educação em saúde dependente apenas das tecnologias de ensino e aspectos relativos ao conteúdo sem haver o mínimo questionamento quanto aos resultados individuais e coletivos e, sem colocar em questão o vínculo dos problemas de saúde e condições de vida de grupos sociais específicos. Desta forma, os métodos atualmente adotados podem não ser muito viáveis para a população, uma vez que deixam a desejar quanto ao seu tempo de duração, alcance de classes sociais e afins. Palavras-chave:Comportamento, População, Problemas.ABSTRACT: Health education is the formation of attitudes and values that lead the company to intelligent behavior, contributing to the benefit of your health and the health of others, such as health education. Health education activities are inserted between the commitments of health professionals, with noticeable that these professionals have an informative character, reviewing and explaining healthy habits and behaviors, where the dissemination of such information, are generally carried out through campaigns and published by from mass media to all the population. This study aimed to understand some of the health education of history and its importance to society. The research for the construction of the literature review was performed using books and data portal. The results showed that the effectiveness of health education depend solely on the educational technologies and aspects of content without having the least question about the individual and collective results, without putting into question the relationship of health problems and living conditions of groups specific social. Thus, methods currently used can't be very feasible for the population, once they leave to be desired as to their duration, range of social and related classes.