Correlation between circadian rhythm related genes, type 2 diabetes, and cancer: Insights from metanalysis of transcriptomics data

Vieira, Thaysa Kelly Barbosa; Leão, Myra Jurema da Rocha; Pereira, Luciana Xavier; Silva, Laryssa Cristina Alves da; Paz, Bruno Batista Pereira da; Ferreira, Ricardo Jansen Santos; Feitoza, Christiane Cavalcante; Duarte, Ana Kelly Fernandes; Rodrigues, Amanda Karine Barros Ferreira; Queiroz, Aline Cavalcanti de; Farias, Karol Fireman de; Koike, Bruna Del Vechio; Marques, Carolinne de Sales; Fraga, Carlos Alberto de Carvalho

doi:10.1016/j.mce.2021.111214

Cited by 15 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An integrated meta-analysis of transcriptomic data showed that circadian rhythm-related genes are downregulated and upregulated in the cortex and hypothalamus samples of mice with sleep deprivation, respectively, with downregulated genes associated with the immune system and upregulated genes associated with oxidative phosphorylation, cancer, and T2DM 130 . Several circadian rhythm-related genes were common to both T2DM and cancer, and seem to associate with malignant transformation and patient outcomes 130 .…”

Section: Sleep Deprivation and Immune-related Disease Outcomesmentioning

confidence: 99%

Role of sleep deprivation in immune-related disease risk and outcomes

et al. 2021

View full text Add to dashboard Cite

Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects of sleep deprivation on health. Sleep exerts an immune-supportive function, promoting host defense against infection and inflammatory insults. Sleep deprivation has been associated with alterations of innate and adaptive immune parameters, leading to a chronic inflammatory state and an increased risk for infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune and neurodegenerative diseases. Here, we review recent advancements on the immune responses to sleep deprivation as evidenced by experimental and epidemiological studies, the pathophysiology, and the role for the sleep deprivation-induced immune changes in increasing the risk for chronic diseases. Gaps in knowledge and methodological pitfalls still remain. Further understanding of the causal relationship between sleep deprivation and immune deregulation would help to identify individuals at risk for disease and to prevent adverse health outcomes.

show abstract

Section: Sleep Deprivation and Immune-related Disease Outcomesmentioning

confidence: 99%

Role of sleep deprivation in immune-related disease risk and outcomes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The expression of ARNTL2 was higher in LUAD, as demonstrated in our study. ARNTL2 has also been found to be upregulated in BLCA, BRCA, COAD, and READ [39] . We discovered that high ARNTL2 expression was associated with lymph node metastasis in patients with lung adenocarcinoma; similar findings have been reported in colorectal cancer [40] .…”

Section: Discussionmentioning

confidence: 99%

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma

Zhang

Shan

Jin

et al. 2022

Translational Oncology

View full text Add to dashboard Cite

“…Differentially expressed gene analysis RNA-seq and clinical information data from Geodataset and The Cancer Genome Atlas (TCGA) were performed as previously described [31][32][33] .Basically, we used TCGAbiolinks and the TCGAbiolinksGUI R package to compare differentially expressed genes (DEGs) in normal and melanoma (SKCM) and oral squamous cell carcinoma (OSCC). Normal samples were obtained from The Genotype-Tissue Expression (GTEx) project.…”

Section: Methodsmentioning

confidence: 99%

Clock-related genes disruption and melatonin administration are associated with melanoma and oral cancer, but not with skin carcinoma

Duarte,

Gomes,

Rocha

et al. 2024

Preprint

View full text Add to dashboard Cite

Melatonin plays an important role in the regulation of circadian clock genes, whose deregulation contributes to cancer development. In this study, we first performed a bioinformatic analysis for melanoma, non-melanoma skin cancer, and oral squamous cell carcinoma to evaluate what clock-related genes are deregulated when compared to normal tissue. Further, we administrated melatonin in cell cultures for cutaneous squamous cell carcinoma, skin melanoma, and oral squamous cell carcinoma to observe changes in cancer cell phenotypes. Later, we evaluated gene expressions associated to clock genes, cancer cell proliferation, migration, invasion, and apoptosis. In summary, clock-related genes are deregulated in both cancers. Skin melanoma and oral cancer presented commonly deregulated clock related genes and were associated with poor survival and chemoresistance, according to bioinformatic analysis. In cell culture, melatonin administration increased Per2, Cry1, Cry2 and Bmal1 mRNA expression levels and decreased Clock gene mRNA levels. Per2, Cry1, Cry2, and Bmal1 genes belong to tumor suppressor genes that can control cell proliferation, cell death, DNA damage, and repair system. Te hypothesized that changes in the expression of clock related-genes in cancer could be responsible for metabolic changes that could lead to the cancer aggressiveness. Melatonin administration showed changes in melanoma and oral cancer phenotypes. Melatonin also seems to influence melanoma and oral tumor progression through Mki67, Hif-1a, Vegfa, Col1a1, Cdh1, Casp3, Bax, Bcl2, Mmp9, Per2, Cry1, Cry2, Bmal1 and Clock modulation.

show abstract

Correlation between circadian rhythm related genes, type 2 diabetes, and cancer: Insights from metanalysis of transcriptomics data

Cited by 15 publications

References 30 publications

Role of sleep deprivation in immune-related disease risk and outcomes

Role of sleep deprivation in immune-related disease risk and outcomes

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma

Clock-related genes disruption and melatonin administration are associated with melanoma and oral cancer, but not with skin carcinoma

Contact Info

Product

Resources

About