Association of TNFA (−308G/A), IFNG (+874 A/T) and IL-10 (−819 C/T) polymorphisms with protection and susceptibility to dengue in Brazilian population

Santos, Ana Caroline Melo dos; Moura, Edilson Leite de; Ferreira, Jean Moisés; Moura, Alexandre Wendell Araujo; Ferreira, Ailson Darlan Sales; Bezerra, Rubens Pereira; Figueiredo, Diego de Siqueira; Farias, Karol Fireman de; Andrade, Tiago Gomes de; Figueiredo, Elaine Virgínia Martins de Souza

doi:10.1016/j.apjtm.2017.10.009

Cited by 11 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 19 , 20 , 21 Thus the high levels of IL-10 in infected individuals could have been a result of the infection rather than the cause of infection. However, there are previous reports that high levels of IL-10 predispose to reinfection 8 , 9 , 10 and we found that no individuals with the IL-10 TT genotype (which was also associated with lower IL-10 levels) were infected. Taken together, these observations support the hypothesis that the association between IL-10 levels and schistosomiasis in our study is due to higher IL-10 levels predisposing to infection and lower levels conferring protection.…”

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe

Marume

Chimponda

Vengesai

et al. 2021

African Journal of Laboratory Medicine

View full text Add to dashboard Cite

Background: Knowledge gaps exist between host genetic factors and susceptibility to schistosomiasis.Objective: This study determined cytokine levels and single nucleotide polymorphisms of tumour necrosis factor (TNF)-α (rs1800629) and interleukin (IL)-10 (rs1800871) and their possible impact on susceptibility to schistosomiasis in preschool-age children in the Madziva area of Shamva district, Mashonaland Central province, Zimbabwe.Methods: Urogenital schistosomiasis was diagnosed using the urine filtration method, while a sandwich enzyme-linked immunosorbent assay was used for cytokine level determination. The survey was done in August 2015 and reinfection levels post treatment were assessed at 3, 6 and 12 months. Amplification refractory mutation system polymerase chain reaction with visualisation on 2% agarose gel electrophoresis was used for genotyping.Results: Schistosomiasis prevalence was found to be 10.5% (59/563). Reinfections were detected in only six children at 3 months and only one was reinfected at 12 months. There were no significant differences in TNF-α-308 G/A allele or genotype frequencies between the Schistosoma haematobium infected participants (p = 0.360) and uninfected participants (p = 0.279). However, no children with the IL-10-819 TT genotype had schistosomiasis. The TNF-α GG genotype corresponded with significantly lower TNF-α levels when compared with the GA or AA genotypes (p 0.001), and TNF-α levels were significantly lower in infected children compared to uninfected children (p 0.001).Conclusion: Higher TNF-α levels and lower IL-10 levels are potentially protective against schistosomiasis infection. The IL-10-819 TT genotype is potentially protective against infection through its association with lower IL-10 levels.

show abstract

Section: Discussioncontrasting

confidence: 59%

“…Tumour necrosis factor (TFN)-α and interleukin (IL)-10 have been associated with susceptibility and other key immune responses in many diseases including those caused by helminthes. 8 , 9 , 10 We therefore assessed cytokine levels as well as cytokine genotypes in preschool children at risk of schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe

Marume

Chimponda

Vengesai

et al. 2021

African Journal of Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Table 1 presents the characteristics of the nine included studies, along with their genotype and allele frequency distribution of TNF-α -308 G>A and TNF-α -238 G>A gene polymorphisms. Two studies each were from Brazil [ 27 , 31 ] and Mexico [ 26 , 32 ], while one study each from Cuba [ 25 ], India [ 28 ], Malaysia [ 30 ] and Sri Lanka [ 29 ]. Study samples varied from 43 cases [ 25 ] to 196 [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Association of tumour necrosis factor-α (TNF-α) gene polymorphisms (-308 G>A and -238 G>A) and the risk of severe dengue: A meta-analysis and trial sequential analysis

et al. 2018

View full text Add to dashboard Cite

Individual studies have assessed the association between TNF-α-308G>A and TNF-α-238 G>A polymorphisms and severity of dengue infection. However, the results are inconclusive and most studies had small sample sizes. The objective of this study was to summarize the evidence of association between TNF-α-308 G>A and TNF-α-238 G>A and severity of dengue infection.This study follows the preferred reporting items for systematic reviews and meta- analyses of genetic association studies, recommended by PLOS One. We calculated pooled odds ratio and its 95% confidence interval (CI) to estimate the association between TNF-α-308 G>A or TNF-α-238 G>A and the risk of severe dengue infections. To determine the information size required for this meta-analysis study, a trial sequential analysis (TSA) was done. Eight studies (640 cases and 1275 controls), which assessed the association of TNF-α-308 G>A or TNF-α-238 G>A and the risk of DHF were included. Overall, we found no significant association between TNF-α-308 G>A and the DHF risk in the allelic model (OR, 0.91; 95% CI, 0.51–1.63), the recessive model (OR,1.32;95%CI,0.73–2.37), the dominant model (OR,0.93;95%CI:0.59–1.47) or the additive model (OR,1.43,95;95%CI:0.79–2.59). There was also no significant association between TNF-α-238 G>A and DHF risk under the allele contrast model (OR:1.51;95%CI:0.88–2.58), the recessive model (OR,1.48,95% CI:0.33–6.58), the dominant model (OR,1.48;95%CI:0.56–3.92), or the additive model (OR:1.5;95%CI:0.34–6.69). On subgroup analysis, neither the Asian population nor the non-Asian population showed significant association between TNF-α-308 G>A/TNF-α-238 G>A and the DHF risk under any genetic models. Leave-one-out meta-analysis showed stability of the results. TSA plots suggested that the sample size in this meta-analysis study was below the required information size.The findings suggest an inclusive evidence of the association between TNF-α-308/ TNF-α-238 G>A and the risk of developing severe dengue infection. Large studies with evidence of Hardy-Weinberg equilibrium, assessing gene-gene interactions are recommended.

show abstract

“…These results were contradicted in another work, where TNF-α at high and medium concentration inhibited DENV replication in human dendritic cells, a primary DENV target cells (cited in [40]). The promoter -308A allele has been related to enhanced TNF-α gene transcriptional activity [41], and different studies have associated it with diverse dengue phenotypes or failed to do so: protective against development of DHF/DSS in Malaysia [40]; not associated in Mexico [42]; dominant model marginally protective against DF in Brazil [43]; risk factor for DHF in Venezuela [44] and Cuba [45].…”

Section: Introductionmentioning

confidence: 99%

“…In this work, we applied population genetics-informed meta-analyses to evaluate the genetic risk/protection conferred by 10 SNPs across seven genes mostly associated with dengue in the literature (PLCE1, TNFA, DC-SIGN/CD209, OAS1, OAS3, FCGR2A/CD32 and MICB; Table 1). We surveyed the literature for case-control cohorts [25,26,27,29,30,35,36,38,40,42,43,44,48,49,53,54,55,56,57,58], took advantage of available datasets chip-genotyped ( [47,59]and Oliveira et al 2018), and added a few case-control cohorts of our own (mostly Cambodia, Vietnam and few Brazilian individuals).…”

Section: Introductionmentioning

confidence: 99%

Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease

Oliveira

Saraiva

Cavadas

et al. 2018

Infection, Genetics and Evolution

View full text Add to dashboard Cite

Population genetics theory predicted that rare frequent markers would be the main contributors for heritability of complex diseases, but meta-analyses of genome-wide association studies are revealing otherwise common markers, present in all population groups, as the identified candidate genes. In this work, we applied a population-genetics informed meta-analysis to 10 markers located in seven genes said to be associated with dengue fever disease. Seven markers (in PLCE1, CD32, CD209, OAS1 and OAS3 genes) have high-frequency and the other three (in MICB and TNFA genes) have intermediate frequency. Most of these markers have high discriminatory power between population groups, but their frequencies follow the rules of genetic drift, and seem to have not been under strong selective pressure. There was a good agreement in directional consistency across trans-ethnic association signals, in East Asian and Latin American cohorts, with heterogeneity generated by randomness between studies and especially by low sample sizes. This led to confirm the following significant associations: with DF, odds ratio of 0.67 for TNFA-rs1800629-A; with DHF, 0.82 for CD32-rs1801274-G; with DSS, 0.55 for OAS3-rs2285933-G, 0.80 for PLCE1-rs2274223-G and 1.32 for MICB-rs3132468-C. The overall genetic risks confirmed sub-Saharan African populations and descendants as the best protected against the severer forms of the disease, while Southeast and Northeast Asians are the least protected ones. European and close neighbours are the best protected against dengue fever, while, again, Southeast and Northeast Asians are the least protected ones. These risk scores provide important predictive information for the largely naïve European and North American regions, as well as for Africa where misdiagnosis with other hemorrhagic diseases is of concern.

show abstract

Association of TNFA (−308G/A), IFNG (+874 A/T) and IL-10 (−819 C/T) polymorphisms with protection and susceptibility to dengue in Brazilian population

Abstract: This research identifies the association of the IFNG (+874 A/T), TNFA (-308G/A), IL-10 (-819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue.

Cited by 11 publications

References 31 publications

Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe

Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe

Association of tumour necrosis factor-α (TNF-α) gene polymorphisms (-308 G>A and -238 G>A) and the risk of severe dengue: A meta-analysis and trial sequential analysis

Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease

Contact Info

Product

Resources

About