Hypoplasia and retardation of the fetus are prominent developmental features in trisomies of the mouse. They are caused by disturbances and depression of growth in vivo. In a study of growth parameters of two trisomic mice. Ts12 and Ts19, cell cultures were initiated from Ts12, Ts19 and normal embryos at late developmental stages. Kinetics of growth of these cells under different conditions show that growth is not significantly affected in either of the trisomies. These results indicate that the trisomy‐dependent growth impairment in vivo is not expressed under the experimental growth conditions used in vitro. It remains possible, though, that other autosomal trisomies of the mouse may show a different behaviour in this respect. If so, this may be considered specific to the tested trisomic chromosome and not as a general phenomenon of any trisomy.
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