To develop highly efficient synthetic reactions is quite important in organic chemistry. Cross dehydrogenative couplings (CDC) utilize C−H bonds of substrates to construct new C−X (X=C, S, O, N, P) bonds. For CDC, the pre‐functionalization of reaction substrates can be avoided and the C−X (X=C, S, O, N, P) bonds can be newly formed by simple and efficient synthesis routes. Meanwhile, water is increasingly used as a substitute for organic solvents in cross‐dehydrogenative coupling because of its rich content, non‐toxicity, and non‐ flammability. In recent years, organic chemists are devoted their efforts to explore the cross dehydrogenative couplings (CDC) in aqueous phase which feature high atom utilization rate and environmental friendliness. Herein, we summarized the recent advances in the construction of C−C, C−S, C−O, C−N, and C−P bonds through CDC reactions of C−H bonds in water.
An efficient C-S/S-S formation for the chemoselective synthesis of aryl dithiocarbamate (C-S formation) and aryl dialkylcarbamo(dithioperoxo)thioate (S-S formation) was studied. The chemoselectivity could be controlled by modulating the reaction temperature, base, and catalyst. The transformation [a]
Compounds containing S–X (X = N, P, O) bonds are commonly found in organic synthesis, medicinal chemistry and pesticide chemistry. The use of transition metal catalysts enables the development of more efficient and environmentally friendly synthetic processes. The reaction strategy between sulfur sources (such as sulfenyl or sulfonyl compounds) and organic substrates (such as amines, phosphites, or alcohols) is one of the most important methods to give S–X (X = N, P, O) bond. Herein, we summarize the recent research progress on the S–X (X = N, P, O) bond formation catalyzed by transition metals, mainly starting from sulfur sources containing sulfenyl or sulfonyl group.
The Front Cover shows an efficient C–S/S–S formation for the chemo‐selective synthesis of aryl dithio‐carbamates and aryl dialkylcarbamo‐(dithioperoxo)thioates. The approach uses inexpensive and readily available diphenyl disulfides and tetramethyl thiuram disulfides as starting materials, a series of aryl dithiocarbamates and aryl dimethylcarbamo(dithioperoxo)thioates could be furnished smoothly in moderate to good yields by modulating the reaction temperature, base, and catalyst. The S–S bond formation was confirmed by X‐ray crystallography. More information can be found in the Full Paper by Z.‐B. Dong et al.
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