Nitric oxide-releasing S-nitrosothiol-modified silica/chitosan core–shell nanoparticles

Chang, Wen-Ming; Peng, Kang; Hu, Teh Min; Chiu, Shih Jiuan; Liu, Ying‐Ling

doi:10.1016/j.polymer.2014.12.020

Cited by 15 publications

(9 citation statements)

References 34 publications

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“…In recent years, nanoparticle systems for intracellular NO delivery have attracted significant attention [12] to address problems associated with traditional NO donors such as low stability, burst release, and low intracellular delivery efficiency. [7,13] For examples, polymer, [14][15][16] silica, [17,18] and metal based [19] nanoparticles have been reported for NO delivery, either by encapsulation of commercial NO donors or post modification of NO donating moieties. Porous silica nanoparticles are reported to increase the stability of SNO compared to nonporous counterparts due to the so-called "cage effect".…”

Section: Introductionmentioning

confidence: 99%

“…[17] SNO modified silica nanoparticles have been applied for various cellular delivery applications. [18,[20][21][22] Nevertheless, cancer cells have higher GSH concentration (up to 10 mm) in their cytosol compared to normal cells (1-2 mm). [23,24] This variation is expected to produce more intracellular NH 3 instead of NO in GSH rich cells, thus limiting the efficacy of NO donors.…”

Section: Introductionmentioning

confidence: 99%

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Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles

Theivendran

2021

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Cellular delivery of nitric oxide (NO) using NO donor moieties such as S‐nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles

Theivendran

2021

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“…Polyurethane (PU) has gained acceptance in the biomedical eld for its excellent mechanical properties and biocompatibility. [1][2][3][4][5] Their segmented block copolymer character endows PUs with a wide range of versatility in terms of tailoring their related properties to satisfy specic medical requirements. PU materials have been widely used in articial hearts, pacemaker lead insulation, implantable cardiac valves and so forth.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel antibacterial material containing poly(sulfobetaine) using reverse atom transfer radical polymerization

et al. 2018

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“…4,5 To address these issues, materials which can be decomposed to release NO have been developed as exogenous NO donors for clinical use, including organic nitrates, nitrites, nitrosamines, metal-NO complexes, S-nitrosothiols (RSNOs), and N-diazeniumdiolates (NONOates). [6][7][8][9][10][11][12][13] Among these, NONOates have gained particular attention for their spontaneous dissociation to give off two moles of NO per mole of donor under physiological conditions (i.e. 37 °C, pH 7.4).…”

Section: Introductionmentioning

confidence: 99%

Hollow double-layered polymer microspheres with pH and thermo-responsive properties as nitric oxide-releasing reservoirs

et al. 2015

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Nitric oxide (NO)-releasing hollow double-layered polymer microspheres (HDPMs) with both pH-and thermo-responsive properties in aqueous media are designed and prepared by a multistep process. Hollow double-shelled polymer microspheres with secondary amino groups are prepared by distillation precipitation copolymerization of N-isopropylacrylamide (NIPAAm) with 2-(dimethylamino) ethyl methacrylate (DMAEMA) and EGDMA in presence of SiO 2 /P(2-(ethyl(boc)amino)ethyl methacrylate (bocAmEMA)-co-EGDMA) core-shell microspheres as seeds to obtain SiO 2 /P(bocAmEMA-co-EGDMA)/P(EGDMA-co-DMAEMA-co-NIPAAm) trilayer microspheres with subsequent removal of silica core by hydrogen fluoride aqueous solution and deprotection of secondary amino groups with CF 3 CO 2 H. Hollow polymer microspheres with N-diazenuimdiolated NO donors are prepared by the reaction between secondary amino groups of hollow P(AmEMA-co-EGDMA)/P(EGDMA-co-DMAEMA-co-NIPAAm) microspheres and high pressure of NO (5.0 atm) under basic condition (CH 3 ONa). The resultant microspheres are systematically characterized by TEM, FT-IR, TGA, elemental analysis and dynamic laser scattering (DLS). The final N-diazeniumdiolated hollow double-shelled microspheres show a controlled NO release behavior dependent on pH and temperature in the environments.

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Nitric oxide-releasing S-nitrosothiol-modified silica/chitosan core–shell nanoparticles

Cited by 15 publications

References 34 publications

Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles

Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles

Synthesis and characterization of a novel antibacterial material containing poly(sulfobetaine) using reverse atom transfer radical polymerization

Hollow double-layered polymer microspheres with pH and thermo-responsive properties as nitric oxide-releasing reservoirs

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