Transcranial alternating current stimulation (tACS) is a relatively new non-invasive brain electrical stimulation method for the treatment of patients with Alzheimer's disease (AD), but it has poor offline effects. Therefore, we applied a new combined stimulation method to observe the offline effect on the cognitive function of patients with AD. Here, we describe the clinical results of a case in which tACS combined with sound stimulation was applied to treat moderate AD. The patient was a 73-year-old woman with a 2-year history of persistent cognitive deterioration despite the administration of Aricept and Sodium Oligomannate. Therefore, the patient received tACS combined with sound stimulation. Her cognitive scale scores improved after 15 sessions and continued to improve at 4 months of follow-up. Although the current report may provide a new alternative therapy for patients with AD, more clinical data are needed to support its efficacy.Trial registrationClinicaltrials.gov, NCT05251649.
Auxetic materials are appealing due to their unique characteristics of transverse expansion while being axially stretched. Nevertheless, current auxetic materials are often produced by the introduction of diverse geometric structures through cutting or other pore‐making processes, which heavily weaken their mechanical performance. Inspired by the skeleton‐matrix structures in natural organisms, here we report an integrated auxetic elastomer (IAE) composed of high‐modulus crosslinked poly(urethane‐urea) as a skeleton and low‐modulus non‐crosslinked poly(urethane‐urea) as a complementary‐shape matrix. Benefiting from disulfide bonds and hydrogen bonds‐promoted dual dynamic interfacial healing, the resulting IAE is flat, void‐free, and has no sharp soft‐to‐hard interface. Its fracture strength and elongation at the break are increased to 400% and 150%, respectively, of the values of corrugated re‐entrant skeleton alone, while the negative Poisson's ratio (NPR) reserves within a strain range of 0–104%. In addition, the advantageous mechanical and auxetic properties of this elastomer are further confirmed by finite element analysis. The concept of combining two dissimilar polymers into an integrated hybrid material solves the problem of the deterioration in mechanical performance of auxetic materials after subtractive manufacturing, while preserves the NPR effect in a large deformation, which provides a promising approach to robust auxetic materials for engineering applications.This article is protected by copyright. All rights reserved
Dynamic cross-linked biobased vitrimers can be recycled, reprocessed, and degraded via bond exchange reactions. However, the competitive raw materials and the tedious preparation process still bring challenges for these sustainable...
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