Circ_0003611 regulates apoptosis and oxidative stress injury of Alzheimer’s disease via miR-383-5p/KIF1B axis

Li, Yong; Wang, Hongli; Chen, Li; Wei, Kailun; Liu, Yang; Han, Young-Min; Xia, Xinhui

doi:10.1007/s11011-022-01051-z

Cited by 6 publications

(5 citation statements)

References 33 publications

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“… 165 Circ_0003611‐miR‐383‐5p‐KIF1B axis promoted cell apoptosis in Aβ‐triggered SH‐SY5Y and SK‐N‐SH cells. 165 Moreover, circ_0002945 was overexpressed in serum of AD patients. 166 TNFAIP1 was a direct target of miR‐431‐5p and circ_0002945 functioned as a ceRNA to control TNFAIP1 expression via miR‐431‐5p competition.…”

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

“…Circ‐HUWE1‐miR‐433‐3p‐FGF7 axis could promote cell apoptosis in Aβ 40 ‐induced SK‐N‐SH cells 164 . Similarly, the expression of circ_0003611 was markedly upregulated in the serum of patients with AD relative to healthy controls 165 . RIP and dual‐luciferase reporter assay identified that circ_0003611 works as a miR‐383‐5p sponge, and miR‐383‐5p directly targets KIF1B 165 .…”

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

“… 164 Similarly, the expression of circ_0003611 was markedly upregulated in the serum of patients with AD relative to healthy controls. 165 RIP and dual‐luciferase reporter assay identified that circ_0003611 works as a miR‐383‐5p sponge, and miR‐383‐5p directly targets KIF1B. 165 Circ_0003611‐miR‐383‐5p‐KIF1B axis promoted cell apoptosis in Aβ‐triggered SH‐SY5Y and SK‐N‐SH cells.…”

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

“… 165 RIP and dual‐luciferase reporter assay identified that circ_0003611 works as a miR‐383‐5p sponge, and miR‐383‐5p directly targets KIF1B. 165 Circ_0003611‐miR‐383‐5p‐KIF1B axis promoted cell apoptosis in Aβ‐triggered SH‐SY5Y and SK‐N‐SH cells. 165 Moreover, circ_0002945 was overexpressed in serum of AD patients.…”

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

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NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Li,

Jin,

Tan

et al. 2023

CNS Neurosci Ther

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AimsThe aim of this review is to systematically summarize and analyze the noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in the cell apoptosis among Alzheimer's disease (AD) in recent years to demonstrate their value in the diagnosis and treatment of AD.MethodsWe systematically summarized in vitro and in vivo studies focusing on the ncRNAs in the regulation of cell apoptosis among AD in PubMed, ScienceDirect, and Google Scholar.ResultsWe discover three patterns of ncRNAs (including ‘miRNA‐mRNA’, ‘lncRNA‐miRNA‐mRNA’, and ‘circRNA‐miRNA‐mRNA’) form the ncRNA‐based regulatory networks in regulating cell apoptosis in AD.ConclusionsThis review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.

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Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

Section: Abnormally Expressed Ncrnas In Ad Patients In Regulating Cel...mentioning

confidence: 99%

See 2 more Smart Citations

NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Li,

Jin,

Tan

et al. 2023

CNS Neurosci Ther

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“…A large number of studies have shown that miR-383-5p can directly target the 3′-untranslated region of some pro-tumor genes to weaken cancer-related processes, including cell proliferation, cell development and the glycolysis pathway [ 16 , 17 , 18 ]. miR-383-5p is used as a tumor inhibitor in many types of cancer, including breast cancer, gastric cancer, and liver cancer [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

miR-383-5p Regulates Preadipocyte Proliferation and Differentiation by Targeting RAD51AP1

Wang,

Shao,

Zhang

et al. 2023

IJMS

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Obesity has become a major health problem worldwide, and increasing evidence supports the importance of microRNAs (miRNAs) in its pathogenesis. Recently, we found that miR-383-5p_1 is highly expressed in the perirenal fat of high-fat-fed rabbits, but it is not yet known whether miR-383-5p is involved in lipid metabolism. Here, we used transcriptome sequencing technology to screen 1642 known differentially expressed genes between miR-383-5p mimic groups and miR-383-5p negative control groups. Gene Ontology Resource (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were enriched in the pathway related to lipid metabolism, and glycine biosynthesis, the NOD receptor signal pathway and nonalcoholic fatty liver were significantly enriched. Afterwards, our research results indicated that miR-383-5p can promote the proliferation and differentiation of rabbit preadipocytes, and there is a direct targeting relationship with RAD51AP1. Mechanistically, miR-383-5p directly interacts with the lipid metabolism and participates in adipogenesis and lipid accumulation by targeting RAD51AP1. In conclusion, our data highlight a physiological role for miRNA in lipid metabolism and suggest the miR-383-5p/RAD51AP1 axis may represent a potential mechanism for controlling lipid accumulation in obesity.

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