A facile four-armed AIE fluorescent sensor for heparin and protamine

Gao, Yuxia; Wei, Kailun; Li, Jianzuo; Liu, Ying; Hu, Jun

doi:10.1016/j.snb.2018.09.054

Cited by 57 publications

(16 citation statements)

References 34 publications

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“…All the phenomena demonstrated that 27 was a rather promising fluorescent probe for the detection of the interaction between heparin and protamine in biological systems. Similar work was reported by Hu, Li et al and Zhu, Zhang et al with ammonium modified TPE derivative 28 or silole derivative 29 . Besides the typical AIE-gens such as TPE and silole, fluorescent probes 30 and 31 with other AIE-gens were reported by Tong’s and Liu’s groups, which were all demonstrated suitable for heparin monitoring during postoperative and long-term care (0.2–1.2 U/mL) …”

Section: Polysaccharidesupporting

confidence: 86%

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

et al. 2020

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Sugars are abundant natural sources existing in biological systems, and bioactive saccharides have attracted much more attention in the field of biochemistry and biomaterials. For better understanding of the sugar-based biomaterials and biological sciences, aggregation-induced emission luminogens (AIE-gens) have been widely employed for detection, tracing, and imaging. This review covers the applications of AIE molecules on sugar-based biomaterials by three parts, polysaccharide, oligosaccharide, and monosaccharide, mainly focusing on saccharide detection, stimuli response materials preparation, bioimaging, and study of the AIE mechanism. These excellent works suggest the promising future of the sugar-based AIE bioconjugates, considering that the naturally designed and elaborately functionalized saccharides play discriminate roles in biological processes and AIE-tagged species may work as an indicator in each case. However, there are a lot of sugar-based biological species that have not been touched, such as mucopolysaccharides and glycoproteins on the cell surface and in the cell plasma. Based on these features, we enthusiastically look forward to more glorious developments in this bright research area.

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Section: Polysaccharidesupporting

confidence: 86%

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

et al. 2020

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“…Gao et al . [ 57 ] reported the heparin detection capability of an AIEgen containing four amino groups, that is, TPE‐NH 2 . The mechanism was due to the sulfate and carboxylate groups with negative charge existing on the heparin peptide, promoting electrostatic interactions with the amino groups.…”

Section: Detection Of Miscellaneous Proteins Via Aie‐promoted Protein Imagingmentioning

confidence: 99%

“…Furthermore, it could be applied in the clinical therapy of cardiovascular and cerebrovascular diseases, diabetes, hemodialysis, and decreases the accumulation of antibiotics. [54][55][56] Gao et al [57] reported the heparin detection capability of an AIEgen containing four amino groups, that is, TPE-NH 2 . The mechanism was due to the sulfate and carboxylate groups with negative charge existing on the heparin peptide, promoting electrostatic interactions with the amino groups.…”

Section: Protamine and Heparinmentioning

confidence: 99%

AIEgen‐enhanced protein imaging: Probe design and sensing mechanisms

et al. 2021

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Proteins are the building blocks of life, regarded as one of the most complex and crucial biomacromolecules in biological systems, and playing a significant role in executing genes and transferring genetic information. According to recent research, due to the structural intricacy of proteins and their sensitivity to physical and chemical degradation processes, they could be utilized as biomarkers or therapeutic agents in the diagnosis, treatment, or even prevention of different diseases. Therefore, modern pathways have been developed for understanding the function of proteins, resulting in intriguing approaches in the field of protein‐related diseases. The diagnostic strategies to deal with such diseases, including protein analysis, protein quantification, and protein imaging, were argued in depth. Meanwhile, the aggregation‐induced emission (AIE) concept and its potential applications for real‐time imaging make AIE luminogens (AIEgen) attractive for protein imaging. In general, AIEgens refer to those luminogenic chemicals that are nonluminescent in solution, but luminescent in either the aggregated or solid states. This review is focused on the emergence of AIE materials in protein tracking, detecting, and imaging for medical applications.

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“…Taking into account the applications of fluorescent aggregates, many research groups have developed fluorescent aggregates for sensing of various analytes . However, there is still a wide scope for the development of a fluorescent aggregates based sensor for amine derivatives.…”

Section: Chemosensors For ‘‘Turn‐off’’ Response Of the Detection Of Amentioning

confidence: 99%

Aggregation‐Induced Emission: A Tool for Sensitive Detection of Amines

Gupta

2019

ChemistrySelect

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The aggregation-induced emission (AIE) phenomenon has shown great potential to develop sensors for amine detection. The AIE-active fluorescent probes are free from the aggregation-caused fluorescence quenching, which is a major problem in the conventional fluorescent probes. The fluorescent aggregates formed by AIE strategy offer advantages such as high selectivity, sensitivity, low background interference as well as the simplicity of the fluorescence technique. This review aims to highlight the recent developments of AIE-active probes for the detection of amine derivatives. We will focus our discussion on the AIE concept to develop ''turn on'' and ''turnoff'' fluorescent sensors for the detection of amine derivatives. Thereafter, we will discuss the various examples of amine sensor with their detection mechanism. Finally, we will give a future perspective for the development of AIE-based amine sensors. We believe, this review will inspire scientists of this emerging world for the development of new amine sensors.

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A facile four-armed AIE fluorescent sensor for heparin and protamine

Cited by 57 publications

References 34 publications

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

AIEgen‐enhanced protein imaging: Probe design and sensing mechanisms

Aggregation‐Induced Emission: A Tool for Sensitive Detection of Amines

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