Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from the catechol groups and therapeutic effect of epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel dressing can be conveniently obtained through copolymerization of the complex formed by EGCG and 3‐acrylamido phenylboronic acid (APBA) (the formation of boronate ester bond) and acrylamide. The resulting hydrogel features adequate mechanical properties, self‐healing capability, and tissue adhesiveness. Otherwise, the substantial release of EGCG can not only realize anti‐oxidation, antibacterial, anti‐inflammatory and proangiogenic effect, and modulation of macrophage polarization to accelerate wound healing, but also facilitate easy dressing change. This advanced hydrogel provides a facile and effective way for diabetic chronic wound management and may be extended for the therapy of other complicated wound healings.

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Stable mechanical properties under cyclic mechanical loads are critical for the applications of hydrogels in flexible electronics and tissue engineering. However, most existing tough hydrogels still face obvious notch sensitivity and suffer from fatigue fracture under continuous load. Designing hydrogels with multifunctional properties, such as high stretchability, toughness, and excellent antifatigue fracture, through a facile strategy is on demand. In this work, the nanocomposite hydrogels with comprehensive mechanical properties were prepared by one-pot polymerization of acrylamide (AM), isocyanoethyl methacrylate-glutamine (IEM-Gln), and Laponite XLG nanosheets. Owing to the potent hydrogen bonds formed by urea groups in IEM-Gln and hydrogen-bonding interaction between the polymer chain and nanoclays, the presented nanocomposite hydrogels displayed excellent mechanical properties (tensile strength of 160 kPa, stretchability of 2600%, compressive strength of 2.3 MPa, and toughness of 3300 J/m2). It was noteworthy that the hydrogels exhibited excellent notch insensitivity and fatigue fracture resistance, and even after 50 cycles, there was no measurable crack propagation observed. In addition, the introduction of clay nanosheets into the gelation system endowed the composite hydrogels with outstanding hemostatic activity and tissue adhesiveness. The nanocomposite hydrogels could not only reduce the skin tension of the wound tissue by their high tensile properties but also accelerate hemostasis in the first stage of wound healing, both of which led to the fast healing of skin wound in mice.

Excellent wound dressings maintain a warm and moist environment, thus accelerating wound healing. In this study, we cross-linked gelatin and hyaluronic acid with ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride in different ratios (gelatin/hyaluronic acid = 8:2, gelatin/hyaluronic acid = 5:5, gelatin/hyaluronic acid = 2:8), and explored the effects and mechanisms of gelatinhyaluronic acid hydrogels on wound healing. This was done by examining dressing properties, such as fluid uptake ability, water vapor transmission rate, and the rate of water evaporation. We further verified biological function by using in vitro and in vivo wound models. The hydrogels display appropriate fluid uptake ability and good water vapor transmission rate and rate of water evaporation all of which can provide an adequate moisture environment for wound healing. Cell cytotoxicity and proliferation tests show that the hydrogels have no cytotoxicity, furthermore, gelatin/hyaluronic acid = 8:2 hydrogels have the potential to promote cell proliferation. Animal wound models demonstrate that the hydrogels can effectively promote wound healing in vivo, in particular, the gelatin/hyaluronic acid = 8:2 group which promoted the most rapid healing. Accordingly, gelatin-hyaluronic acid dressings, especially the gelatin/hyaluronic acid = 8:2 hydrogels, have a promising outlook for clinical applications in wound healing.

Development of hydrogel-based flexible electronics with robust elasticity, low hysteresis, and excellent durability is still challenging. Herein, for the first time, B–N coordination was employed as the main driving force to promote gelation by free radical polymerization of acrylamide and 3-acrylamidophenylboronic acid. Owing to the outstanding stability of B–N coordination, the hydrogels could retain their initial stress (>95%) during 500 tension cycles (strain of 200%) with <10% hysteresis. Moreover, the addition of NaCl elevated the mechanical properties (break stress of 0.21 MPa and fracture strain of 1600%) and imparted high electrical conductivity (4.8 S/m) and superior gauge factor (10.2) to the hydrogels. The conductive hydrogels could accurately distinguish various deformations (2.5–200% tensile strain and 1–25 kPa compressive stress) and successively output reliable electrical signals with super durability (1000 tensile cycles with a strain of 100% and 1000 compressive cycles with a stress of 15 kPa). Combined with moderate tissue adhesiveness, the conductive hydrogels can monitor various human activities with constant outputs. This work offers a new solution to integrate high stretchability, robust elasticity, and low hysteresis into noncovalent cross-linked hydrogels, and may show vast potential in the development of flexible electronic devices.

Noncovalent cross-linked hydrogels with promising mechanical properties are on demand for applications in tissue engineering, flexible electronics, and actuators. However, integrating excellent mechanical properties with facile preparation for the design of hydrogen bond cross-linked hydrogels is still challenging. In this work, an advanced hydrogel was prepared from acrylamide and N-acryloyl phenylalanine by one-pot free-radical copolymerization. Owing to hydrophobicity-assisted multiple hydrogen bonding interactions among phenylalanine derivatives, the hydrogels exhibited fascinating mechanical behaviors: tensile strength of 0.35 MPa, elongation at break of 2100%, tearing energy of 1134 J/ m 2 , and compression strength of 3.56 MPa. The hydrogels also showed robust elasticity and fatigue resistance, and the compression strength did not show any decline, even after 100 successive cycles, as well as promising self-recovery property. In addition, the cytotoxicity test in vitro proved that the hydrogel showed good biocompatibility with normal human liver cells (LO2 cells). The excellent stretchability, robust elasticity, high toughness, fatigue resistance, and biocompatibility of the hydrogel demonstrated its vast potential in the biomedical field and flexible electronic devices.

In article number 2009442, Ang Li, Yilong Cheng, and co‐workers develop a facile dressing strategy via one‐pot radical copolymerization of acrylamide and the complex formed through a boronate ester bond by 3‐acrylamido phenylboronic acid and green tea derivative epigallocatechin‐3‐gallate. The resulting hydrogels exhibit good mechanical strength, adequate tissue adhesiveness, fast self‐healing capability, easy dressing change, and multiple therapeutic effects, all of which provide a promising and practical method for effective diabetic chronic wound management.

This study compares how government research and development (R&D) subsidy and knowledge transfer from universities and public research institutions stimulate a firm's new product development. More importantly, we emphasize that the effects of these governmental R&D policies on new product development can be achieved not only directly, but also via a mediating role – a firm's innovation capability. Furthermore, we test how other external knowledge sources (such as knowledge from universities and public research institutions) interact with government R&D support to stimulate new product development. The results, based on an investigation of 270 Chinese firms, suggest that both government R&D subsidy and knowledge transfer from universities and public research institutions enhance new product development. The results also show that although government R&D subsidy and knowledge transfer from universities and public research institutions has a direct impact on new product development, innovation capability does mediate the above relationships. Moreover, unlike the findings that other external knowledge sources have a direct influence on new product development as indicated by the previous literature, our findings suggest that external knowledge sources substitute with the government R&D subsidies and complement with knowledge transfer from universities and public research institutions. The results confirm the old sayings that teaching to fish (knowledge transfer from universities and public research institutions can complement with other external knowledge sources) is much better than giving fish (government R&D subsidies substitute other external knowledge sources). This paper enriches current literature of government R&D support policies to firm new product development by providing empirical evidences.