Chronic Diabetic Wound Treatment: Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment (Adv. Funct. Mater. 18/2021)

Abstract

In article number 2009442, Ang Li, Yilong Cheng, and co‐workers develop a facile dressing strategy via one‐pot radical copolymerization of acrylamide and the complex formed through a boronate ester bond by 3‐acrylamido phenylboronic acid and green tea derivative epigallocatechin‐3‐gallate. The resulting hydrogels exhibit good mechanical strength, adequate tissue adhesiveness, fast self‐healing capability, easy dressing change, and multiple therapeutic effects, all of which provide a promising and practical method for effective diabetic chronic wound management.

Multifunctional DNA Hydrogel Enhances Stemness of Adipose‐Derived Stem Cells to Activate Immune Pathways for Guidance Burn Wound Regeneration

“…[11] Macrophages are the essential signal messengers to determine whether chronic wounds can transform from the inflammatory to the remodeling stage. [46] M1 macrophages mainly activate inflammation response, and M2 macrophages are primarily responsible for immune regulation and tissue remodeling. [14] According to clinical reports, once ADSCs received the signal from the injury site, they could independently secrete various growth factors and critical cytokines, and promote macrophages to transform the M2 phenotype.…”

“…Hemocompatibility is also an essential property of biomaterials. [46] The hemolysis rate (HR) of the CGMHM, pH-l-DNA gels, pH-l-DNA gels/b, and M/pH-l-DNA gels/b were quantitatively evaluated. The hemolysis rate of supernatant of all samples was <0.8%, indicating that all materials had satisfactory biocompatibility (Figure S7c, Supporting Information).…”

A Composite Hydrogel Containing Mesoporous Silica Nanoparticles Loaded With Artemisia argyi Extract for Improving Chronic Wound Healing

“…Meanwhile, macrophages can coordinate the complex processes of cell proliferation, infection, inflammation, and functional tissue regeneration in the wound (Freund et al, 2020), responding to the wound microenvironment and driving their conversion from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype (Zhao et al, 2021). Hence, hydrogels with the capability of promoting M2 macrophage polarization can accelerate the progression from the inflammatory stage to the proliferative and remodeling stage of wound healing.…”

Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

“…Ideally, dressing products selected based on the clinical evaluation of patients’ wounds should be easy to obtain, with required functions, accelerate wound healing, reduce pain, reduce medical expenses, and even achieve hospital-family personalized treatment through 5G era big data to reduce the number of hospital visits. Therefore, the performance requirements of intelligent multifunctional wound dressing applied to acute and chronic wounds include the following: (1) rapid hemostasis; (2) prevent pathogens and bacteria from entering the wound bed and perfect antibacterial properties; (3) minimize the skin irritation caused by the dressing such as endogenous immunity or friction between the wound and clothing or equipment; (4) actively participate in the regulation of the wound microenvironment, such as in the inflammatory phase, dressings that can promote the transformation from the M1 phenotype to M2 phenotype, shorten the inflammatory phase, and accelerate the arrival of the remodeling phase; − (5) excellent mechanical properties, such as self-healing performance, stretchable, compressible, writability, and tissue adhesion, can prevent the dressing from breaking during movement and exercise; (6) given chronic ulcer wounds that produce a lot of pus, it is necessary to choose dressings with high adsorption properties; − (7) intelligent multifunctional dressing should have the characteristics of monitoring each stage of the wound; (8) microstructure and biochemical properties of the dressing can promote cell adhesion, proliferation and differentiation, skin regeneration, nerve regeneration, and vascular regeneration. ,, Furthermore, microneedle dressing can break traditional drug delivery’s distance and realize direct targeted drug delivery to ulcerative and chronic wounds. Otherwise, the injectable and 3D/4D bioprinting/spray dressings are developing in full swing in the face of vast and irregular wounds.…”