2017
DOI: 10.1177/0885328217702526
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Evaluation of gelatin-hyaluronic acid composite hydrogels for accelerating wound healing

Abstract: Excellent wound dressings maintain a warm and moist environment, thus accelerating wound healing. In this study, we cross-linked gelatin and hyaluronic acid with ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride in different ratios (gelatin/hyaluronic acid = 8:2, gelatin/hyaluronic acid = 5:5, gelatin/hyaluronic acid = 2:8), and explored the effects and mechanisms of gelatinhyaluronic acid hydrogels on wound healing. This was done by examining dressing properties, such as fluid uptake ability, water v… Show more

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Cited by 77 publications
(59 citation statements)
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“…Gelatin–HA‐based biomaterials have also been used for wound dressing. To this end, it is important that the material provides a warm and moist environment to facilitate wound healing . Optimal moisture condition (2,000–2,500 g m −2 day −1 ) was targeted by altering the composition of these gels (gelatin:HA ~ 8:2, 5:5, and 2:8 wt%:wt%).…”
Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning
confidence: 99%
See 1 more Smart Citation
“…Gelatin–HA‐based biomaterials have also been used for wound dressing. To this end, it is important that the material provides a warm and moist environment to facilitate wound healing . Optimal moisture condition (2,000–2,500 g m −2 day −1 ) was targeted by altering the composition of these gels (gelatin:HA ~ 8:2, 5:5, and 2:8 wt%:wt%).…”
Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning
confidence: 99%
“…To this end, it is important that the material provides a warm and moist environment to facilitate wound healing. 244 Optimal moisture condition (2,000-2,500 g m −2 day −1 ) 245 was targeted by altering the composition of these gels (gelatin:HA~8:2, 5:5, and 2:8 wt%:wt %). It has been demonstrated that 8:2 gelatin:HA provided the fastest wound healing in vivo (95% wound healing on day 10 in a mouse fullthickness wound model compared to 78% for the control) with an optimal water vapor transmission rate~2,670 g m −2 day −1 .…”
Section: Gelatin-hyaluronic Acidmentioning
confidence: 99%
“…Polymeric scaffolds can be engineered using hydrogels that are made up of highly hydrophilic and crosslinked three-dimensional (3D) polymer networks [7,8,9]. However, traditional hydrogels often exhibit a nanoporous network that can limit cell motility, proliferation, and survival, as well as poor mechanical flexibility [10,11,12,13,14,15]. On the other hand, cryogels, a unique class of hydrogels prepared via cryopolymerization, exhibit large tunable interconnected macropores, high elasticity, and flexibility [15,16,17,18,19].…”
Section: Introductionmentioning
confidence: 99%
“…HA has been recognized for its role in the formation of the cardiac jelly during heart morphogenesis [26,27,28]. Furthermore, HA can play an important role in angiogenesis and wound healing [12,29]. The polysaccharide is composed of d -glucuronic acid and D- N -acetyl glucosamine repeating units that can be degraded by hyaluronidase enzyme [30,31].…”
Section: Introductionmentioning
confidence: 99%
“…However, the biocompatibility of the composite hydrogel was still not good enough and thus needed further improvement. On the basis of a large number of previous studies, it is found that SA had good softness, which may be used to further change the softness or rigidity of hydrogel, while Gel with good biocompatibility could be used to improve the cytocompatibility of hydrogel . Thus, in the present study, the PAM/GO/Gel/SA composite hydrogels were prepared by adding SA and Gel under the condition of PAM/GO fixation ratio through in situ free polymerization.…”
Section: Discussionmentioning
confidence: 98%