At the moment, the problem of infertility does not lose its relevance. In the structure of this disease, the violation of reproductive function in women is dominant. The present study is devoted to the study of the influence of concomitant extragenital pathology on the success of assisted reproductive technology procedures. The data of 184 women who underwent infertility treatment by ART methods in clinics of the Volgograd region in the period from 2015 to 2020 were analyzed. The following parameters of the patients were studied: age, gynecological history, the main cause of infertility, transferred diseases of non-productive organs, the protocol of ovarian stimulation with gonadotropins, the number of mature follicles by the end of stimulation, the number of received, fertilized eggs, the number of embryos by day 3, 5. It has been established that concomitant extragenital pathology affects the processes of folliculogenesis and qualitatively affects oogenesis.
Aim: to assess an effect of medicinal magnesium-containing composition on gelatinase B expression intensity and morphological parameters of chronic experimental endometrial inflammation.Materials and Methods. There were conducted experiments with 60 sexually mature female Wistar rats to determine an effect of medicinal magnesium-containing composition (contains magnesium chloride – a natural polymineral Bischofite) on gelatinase B activity in endometrial tissues (counting number of gelatinase-B-positive cells and intensity of gelatinase B expression), morphological parameters of cell infiltration, as well as amount of magnesium in red blood cell mass collected from the inferior vena cava and subclavian vein. All such parameters were assessed in experimental animals from 4 groups: group 1 – animals in baseline state, group 2 – control, group 3 – experimental chronic endometritis (CE), group 4 – experimental CE after treatment with medicinal magnesium-containing composition. Results. It was found that use of medicinal magnesium-containing composition increased amount of erythrocyte magnesium up to the baseline level and increased both number and expression intensity of stromal gelatinase B-positive cells. In addition, magnesium level in erythrocyte mass from the inferior vena cava was increased and accompanied with restored eosinophil-plasmacyte as well as significantly elevated macrophage-lymphocyte infiltration in endometrial tissues compared to CE animals lacking therapy. Conclusion. The results of this study allow us to conclude about importance of gelatinase B in pathogenesis of experimental chronic endometrial inflammation as well as an opportunity of regulating gelatinase B activity by applying medicinal magnesium containing drug in pathogenetic therapy of experimental CE.
This literature review of articles devoted to the problem of abortion and pre-abortion counseling has been carried out. The legal features of the development of the right to abortion at the request of a woman are outlined. The main stages in the development of the concept of perinatal psychology and pre-abortion counseling are described. The procedure for conducting pre-abortion counseling in the Russian Federation has been studied. The effectiveness of the existing algorithm was assessed and the prospects for further research aimed at studying and improving the effectiveness of pre-abortion counseling were outlined.
The problem of pregnancy termination is multifaceted. According to the current legislation, women who come to a healthcare facility for an induced termination of pregnancy undergo pre-abortion counseling. During the consultation, the specialist has several tasks: to compare the arguments for pregnancy termination or preservation; to help competently assess the current life situation; to consider ways to solve problems; to provide information about federal and regional support measures for pregnant women and families with children; to inform about possible negative consequences of an artificial termination of pregnancy. The authors believe that in addition to psychological assistance to women in the situation of choice, it is of great importance to provide detailed information about the negative reproductive consequences of abortion, including the problem of premature ovarian insufficiency. Due to the high prevalence of premature ovarian insufficiency among female population, it seems necessary to supplement the existing pre-abortion counseling procedure with a section devoted to the problem of physiological and pathological loss of ovarian reserve and the impact of pregnancy termination on this process. To inform a woman about her risk of premature ovarian insufficiency and about her presence of this condition in general would allow a woman to consciously avoid additional negative influences (smoking, alcohol, stress), make an informed decision about her reproductive plans and their timing, and possibly resort to oocyte cryopreservation methods in cases where the risks of premature ovarian insufficiency are extremely high. When premature ovarian insufficiency is already diagnosed, the only way to have a baby is to use assisted reproductive technology, but with the use of donor eggs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.