Introduction. As is known, the development of invasive cervical cancer is preceded by cervical intraepithelial neoplasia of varying severity, which is a pathological process in which cells with varying degrees of atypia and impaired differentiation appear in the thickness of the stratified squamous epithelium of the cervix.Objective. To study the effect of complex therapy in patients with mild HPV-associated cervical intraepithelial neoplasia on the dynamics of local cytokine status and autoimmunity parameters.Materials and methods. The study included 86 patients aged 35 to 40 years with morphologically verified mild cervical intraepithelial neoplasia. The main group consisted of 52 patients who, along with radio wave destruction of the cervix, were prescribed an immunostimulating drug with antiviral activity “Groprinosin-Richter” 1000 mg 3 times a day for 10 days 10–14 days before destruction and similar 2 courses after 10–14 days after it. The comparison group included 34 patients who underwent only radio wave destruction of the cervix.Results. An analysis of the outcomes of low-grade squamous intraepithelial lesions after 6 months showed that in the main group, CIN I regression was observed in 92.3% of patients, persistence – in 7.7% of cases, while in the comparison group, CIN I regression was noted in 73,5% of cases, persistence – in 26.5% of patients.Conclusions. Conducting complex therapy, including radio wave destruction and the use of a drug with immunostimulating and antiviral activity “Groprinosin-Richter” in patients with low-grade HPV-associated cervical intraepithelial neoplasia, leads to the elimination of the initial imbalance of cytokines and normalization of autoantibody levels, helping to reduce the likelihood of HPV persistence and CIN progression to invasive cervical cancer uterus.
The use of poor-quality pesticides can lead to the development of pest resistance, increased levels of residues in finished products with corresponding risks to human health and the environment. In Ukraine, on the basis of mesotrione, a widely used systemic herbicide, more than 20 compounds, mainly generics, have been registered. To date, due to the lack of relevant data, the risks to humans associated with the consumption of food and drinking water with residues of mesotrione and/or its metabolites have not been definitively established. Aim. To study histomorphological changes caused by mesotrione in a sub chronic experiment on male Wistar Hannover rats. Materials and Methods. Male Wistar Hannover rats (n = 180) were orally administered one of three technical mesotrione samples (A, B, C) for 90 days at doses 0; 0.1; 0.4 and 4 mg/kg of body weight. At the end of the experiment, histological examinations of the main target organs exposed to the toxic effects of mesotrione: liver, kidney and thyroid gland were performed. Results. Changes in the stroma and parenchyma of the liver under the exposure to mesotrione were not observed. Mild thyrotoxic effect at 4 mg/mg mesotrione exposure for samples A and B, as well as mild nephrotoxic effect at 4 mg/mg mesotrione exposure at sample C were detected. The most common changes detected in kidney were the intratubular micro petrifications, eosinophilic content in cortical tubules, the desquamation of the epithelium of the cortical tubules and hydropic degeneration, in the thyroid gland - degenerativedesquamative disorder, focal fibrosis and epithelioid cysts. Conclusions. In a sub chronic experiment in Wistar Hannover male rats, two samples of mesotrione demonstrated a mild thyrotoxic effect at a dose of 4 mg/kg and one sample had a mild nephrotoxic effect at a dose of 4 mg/kg. According to the indicator of nonspecific dystrophic changes in the thyroid gland (samples A and B) and in the renal cortex (sample C), the dose of 0.4 mg/kg can be considered as NOAEL. Key Words: mesotrione, rats, sub chronic experiment, histomorphological changes.
The outcomes of pregnancy and childbirth, which ended with a cesarean section, were studied in accordance with Robson's classification in order to find ways to reduce the frequency of surgical delivery in a level 3 hospital. The mechanisms to reduce the frequency of cesarean section in an obstetric hospital are defined: pregravid preparation in risk groups for preterm delivery and assessment of perinatal risk factors, a personalized approach to methods of pre-induction of parturition in high-risk patients, especially in full-term pregnancy, rational management of parturition, prevention of the first cesarean section, an increase in delivery through the natural birth canal in pregnant women with a scar on the uterus.
Aim: to assess an effect of medicinal magnesium-containing composition on gelatinase B expression intensity and morphological parameters of chronic experimental endometrial inflammation.Materials and Methods. There were conducted experiments with 60 sexually mature female Wistar rats to determine an effect of medicinal magnesium-containing composition (contains magnesium chloride – a natural polymineral Bischofite) on gelatinase B activity in endometrial tissues (counting number of gelatinase-B-positive cells and intensity of gelatinase B expression), morphological parameters of cell infiltration, as well as amount of magnesium in red blood cell mass collected from the inferior vena cava and subclavian vein. All such parameters were assessed in experimental animals from 4 groups: group 1 – animals in baseline state, group 2 – control, group 3 – experimental chronic endometritis (CE), group 4 – experimental CE after treatment with medicinal magnesium-containing composition. Results. It was found that use of medicinal magnesium-containing composition increased amount of erythrocyte magnesium up to the baseline level and increased both number and expression intensity of stromal gelatinase B-positive cells. In addition, magnesium level in erythrocyte mass from the inferior vena cava was increased and accompanied with restored eosinophil-plasmacyte as well as significantly elevated macrophage-lymphocyte infiltration in endometrial tissues compared to CE animals lacking therapy. Conclusion. The results of this study allow us to conclude about importance of gelatinase B in pathogenesis of experimental chronic endometrial inflammation as well as an opportunity of regulating gelatinase B activity by applying medicinal magnesium containing drug in pathogenetic therapy of experimental CE.
The article presents a modern, comprehensive approach to the treatment of anemia in abnormal uterine bleeding in patients with endometrial hyperplastic processes. The effectiveness of therapy with the iron-containing drug Sorbifer Durules was evaluated.
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