The role of metalloproteinases in the exchange of endometrial extracellular matrix proteins in normal and pathological conditions

Tikhaeva, K. Yu.; Рогова, Л Н; Tkachenko, L. V.

doi:10.17116/repro20202604122

Probl. reprod.

2020

DOI: 10.17116/repro20202604122

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The role of metalloproteinases in the exchange of endometrial extracellular matrix proteins in normal and pathological conditions

K. Yu. Tikhaeva¹,

Л Н Рогова²,

L. V. Tkachenko³

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2023

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Cited by 5 publications

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“…Протеазы -это ферменты, ответственные за расщепление белков, в первую очередь катализирующие реакции деградации компонентов внеклеточного матрикса. Матричные металлопротеиназы (MMП) и их ингибиторы (тканевые ингибиторы металлопротеиназы -ТИМП), также относящиеся к белкам острой фазы, играют фундаментальную роль в ремоделировании внеклеточного матрикса как в нормальных, так и в патологических состояниях [45,46]. Изменения внеклеточного матрикса вовлечены в патогенез ожоговых ран, в частности, MMП участвуют в опосредовании ряда биологических процессов, таких, как воспаление, ремоделирование тканей и ангиогенез [46].…”

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Modern Aspects of Burn Injury Immunopathogenesis and Immuno-Biochemical Markers of Wound Healing (Review of Literature)

Кузнецова¹,

Andryukov²,

Polovov³

et al. 2023

RCLD

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Burns are one of the most common traumatic injuries in the world, representing a global public health problem. Major burns (severe burn injury or burn disease) are one of the most life-threatening injuries. There is a great need to identify and monitor the development of complications (sepsis and septic shock, coagulopathy and DIC) in burned patients. The basis of the pathogenesis of burn injury, as well as any general pathological process, is an inflammatory reaction, ultimately aimed at restoring the structure and function of the damaged tissue. A feature of the inflammatory reaction in burn injury is the scale of alteration of the skin and mucous membranes. The review presents the main aspects of the burn injuries immunopathogenesis and the features of post-burn immune dysfunction, manifested by disorders in the innate and adaptive immunity systems. Attention is focused on the role in the immunopathogenesis of developing systemic and local disorders in burn injury. Also the role are discussed of a minor subpopulations of lymphocytes (Treg-, Th-17-, γδT-cells) in the immunopathogenesis and in the bacterial infection protection. The characteristics of the main immuno-biochemical markers of burn injury (cytokines and growth factors, nitric oxide, matrix metalloproteases, bacteria concentration levels) are present. The prognostic role of these biomarkers in assessing of the severity degree of patients with burn injury and wound healing processes is shown. The review has been compiled using references from major databases such as RSCI, Web of Science, PubMed, Scopus and Google Scholar (up to march 2022). After obtaining all reports from database, the papers were carefully analyzed in order to find data related to the topic of this review (60 references).

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unclassified

Modern Aspects of Burn Injury Immunopathogenesis and Immuno-Biochemical Markers of Wound Healing (Review of Literature)

Кузнецова¹,

Andryukov²,

Polovov³

et al. 2023

RCLD

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Evaluation of the influence of Inosine pranobex on the matrix protein system in patients with chronic viral cervicitis

Nevezhkina,

Tulupova,

Markelova

et al. 2023

Med. immunol.

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The reproductive potential of both women and men is declining every year. Many factors contribute to the violation of the reproductive function – chemical, physical, mechanical, psychogenic, however, biological factors have the most pronounced effect on reproduction. Chronic viral cervicitis can be not only the cause of infertility and reproductive losses, but also the development of intraepithelial dysplasia, as well as cervical cancer. PVI, as a monoinfection, is quite rare along with HPV. Other UGIs (urogenital infections) act as common routes of transmission and entry gates. The most common association with PVI is herpesvirus infection. An increase in MMP, both systemically and at the local level, may indicate a violation of cell modeling processes, which contributes to the development of autoimmune inflammation with further destruction of the tissues of the reproductive tract. Activation of MMP promotes the release of HSV from the nerve ganglia and reactivation of the infection. Therapy for HPV and HVI (herpes virus infections) are debatable. There is no single standard of treatment, but there are a number of drugs that have antiviral and immunomodulatory effects. Currently, there are no studies on the dynamics of the effect of HPV and HSV infection on the state of MMPs and TIMPs during Inosine pranobex therapy. Objective: to evaluate changes in matrix metalloproteinases 2 and 9 and their tissue inhibitors types 1 and 2 in patients with human papillomavirus and herpes infections after Inosine pranobex therapy. 6 patients with papillomavirus and herpetic infections were examined and treated with drugs containing the active ingredient Inosine pranobex. The levels of MMP-2, MMP-9 and TIMP-1, TIMP-2 in blood serum were determined using specific reagents from R&D Diagnostics Inc. (USA). The dynamics of indicators in the blood serum of patients with PVI showed a decrease in the level of MMP-2, MMP-9, TIMP-1 with a simultaneous increase in TIMP-2 relative to the values before therapy. In patients with PVI and HVI, Inosine pranobex therapy showed a decrease in MMP-2 and MMP-9 levels, no changes in the content of TIMP-1, but an increase in the serum content of TIMP-2. Prior to the use of therapy, an increase in the ratio in the main groups in comparison with the control group was found, however, the largest increase was found in the group with the association of infections. After therapy, positive dynamics was established in the main groups. Thus, the ratio in group I decreased and became equal to the control values. In the II group of patients, the ratio, despite the decrease, remained higher than the control values and higher in comparison with the I group of women.

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Activity of matrix metalloproteinase type 9 and its relationship with calcification of the thoracic aorta in patients with resistant hypertension: cross-sectional comparative study

et al. 2023

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Background. The extracellular matrix of vessels is degraded under the influence of matrix metalloproteinases (MMPs). MMP type 9 is of particular interest in arterial hypertension (AH) since its activity is regulated by a tissue inhibitor of matrix metalloproteinase type 1 (TIMP1). The balance of their ratio can shift in either direction depending on the disease stage and provoke vascular wall calcification. Objective. This cross-sectional comparative study investigated the level of MMP9 and its type 1 tissue inhibitor and their relationship with the severity of thoracic aorta calcification in patients with resistant hypertension, depending on antihypertensive therapy effectiveness. Material and methods. The study included 92 patients with resistant hypertension. All patients underwent 24-hour blood (BP) pressure monitoring (ABPM), and had their index of the thoracic aorta (ТАС) and the plasma levels of MMP9 and TIMP1 assessed. Results. Patients were divided into groups based on whether they achieved the BP target level according to the results of ABPM: controlled (n=44) and uncontrolled (n=48) resistant AH. In the second group, most estimated parameters of ABPM were higher, and the variants of the daily BP profile for non-dipper and night-peaker systolic blood pressure (SBP) were more common than in the first group. In the second group, a more pronounced increase in TAC, TIMP1, and TIMP1/MMP9 levels was revealed. Evaluation of the relationship between the studied parameters revealed a positive relationship between TAC and age (r=0.683, p 0.00001), hypertension duration (r=0.610, p 0.00001) and a negative relationship with regular antihypertensive therapy duration (r=0.822, p 0.00001). ТАC was higher in individuals with higher values of SBP (r=0.513, р 0.00001), pulse BP (r=0.805, р 0.00001), rate of morning rise in BP (r=0.678, р 0.00001) and insufficient decrease in SBP at night (r=-0.822, р 0.00001). There was a positive correlation of moderate strength TAC with the level of low-density lipoproteins (r=0.490, p=0.0002), TIMP1 (r=0.344, p=0.005) and the TIMP1/MMP9 ratio (r=0.481, p 0.00001). Conclusion. In patients with resistant hypertension, an increase in the TAC was revealed, which has a statistically significant direct correlation with the value of pulse BP, the morning rise in BP, and an insufficient decrease in SBP at night. An imbalance in the TIMP1/MMP9 ratio, rather than an isolated increase in MMP9, can indicate the intensity of the formation and degradation of the extracellular matrix components in patients with resistant AH, which triggers the vascular wall calcification process.

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The role of metalloproteinases in the exchange of endometrial extracellular matrix proteins in normal and pathological conditions

Cited by 5 publications

References 34 publications

Modern Aspects of Burn Injury Immunopathogenesis and Immuno-Biochemical Markers of Wound Healing (Review of Literature)

Modern Aspects of Burn Injury Immunopathogenesis and Immuno-Biochemical Markers of Wound Healing (Review of Literature)

Evaluation of the influence of Inosine pranobex on the matrix protein system in patients with chronic viral cervicitis

Activity of matrix metalloproteinase type 9 and its relationship with calcification of the thoracic aorta in patients with resistant hypertension: cross-sectional comparative study

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