Introduction. As is known, the development of invasive cervical cancer is preceded by cervical intraepithelial neoplasia of varying severity, which is a pathological process in which cells with varying degrees of atypia and impaired differentiation appear in the thickness of the stratified squamous epithelium of the cervix.Objective. To study the effect of complex therapy in patients with mild HPV-associated cervical intraepithelial neoplasia on the dynamics of local cytokine status and autoimmunity parameters.Materials and methods. The study included 86 patients aged 35 to 40 years with morphologically verified mild cervical intraepithelial neoplasia. The main group consisted of 52 patients who, along with radio wave destruction of the cervix, were prescribed an immunostimulating drug with antiviral activity “Groprinosin-Richter” 1000 mg 3 times a day for 10 days 10–14 days before destruction and similar 2 courses after 10–14 days after it. The comparison group included 34 patients who underwent only radio wave destruction of the cervix.Results. An analysis of the outcomes of low-grade squamous intraepithelial lesions after 6 months showed that in the main group, CIN I regression was observed in 92.3% of patients, persistence – in 7.7% of cases, while in the comparison group, CIN I regression was noted in 73,5% of cases, persistence – in 26.5% of patients.Conclusions. Conducting complex therapy, including radio wave destruction and the use of a drug with immunostimulating and antiviral activity “Groprinosin-Richter” in patients with low-grade HPV-associated cervical intraepithelial neoplasia, leads to the elimination of the initial imbalance of cytokines and normalization of autoantibody levels, helping to reduce the likelihood of HPV persistence and CIN progression to invasive cervical cancer uterus.
This literature review of articles devoted to the problem of abortion and pre-abortion counseling has been carried out. The legal features of the development of the right to abortion at the request of a woman are outlined. The main stages in the development of the concept of perinatal psychology and pre-abortion counseling are described. The procedure for conducting pre-abortion counseling in the Russian Federation has been studied. The effectiveness of the existing algorithm was assessed and the prospects for further research aimed at studying and improving the effectiveness of pre-abortion counseling were outlined.
The problem of pregnancy termination is multifaceted. According to the current legislation, women who come to a healthcare facility for an induced termination of pregnancy undergo pre-abortion counseling. During the consultation, the specialist has several tasks: to compare the arguments for pregnancy termination or preservation; to help competently assess the current life situation; to consider ways to solve problems; to provide information about federal and regional support measures for pregnant women and families with children; to inform about possible negative consequences of an artificial termination of pregnancy. The authors believe that in addition to psychological assistance to women in the situation of choice, it is of great importance to provide detailed information about the negative reproductive consequences of abortion, including the problem of premature ovarian insufficiency. Due to the high prevalence of premature ovarian insufficiency among female population, it seems necessary to supplement the existing pre-abortion counseling procedure with a section devoted to the problem of physiological and pathological loss of ovarian reserve and the impact of pregnancy termination on this process. To inform a woman about her risk of premature ovarian insufficiency and about her presence of this condition in general would allow a woman to consciously avoid additional negative influences (smoking, alcohol, stress), make an informed decision about her reproductive plans and their timing, and possibly resort to oocyte cryopreservation methods in cases where the risks of premature ovarian insufficiency are extremely high. When premature ovarian insufficiency is already diagnosed, the only way to have a baby is to use assisted reproductive technology, but with the use of donor eggs.
The purpose of the study was to evaluate the efficacy of treatment of recurrent drug Orungamin depending on the time of occurrence of relapse.Material and methods. 62 women with recurrent candida vulvovaginit is were examined and treated. The mean age of the patients was 35.6 ± 0.7 years. The main group consisted of 32 patients who in the premenstrual period 5 days before the expected date of menstruation were prescribed Orungamin 1 capsule (100 mg) twice a day (200 mg) for 3 days during three consecutive menstrual cycles. The comparison group included women receiving Orungamin three consecutive cycle 3 day 1 capsule (100 mg) 2 times a day, without regard to days of the menstrual cycle.Results. Therapy with Orungamin 100 mg twice a day during the premenstrual period not only helped to increase the effectiveness of the treatment of relapses, but also the quality of life of patients.
The purpose: to consider modern concepts of epidemiology, biological characteristics, pathogenesis, clinical manifestations, principles of therapy and prevention of human papillomavirus infection.Basic provisions. In the last decade, there has been a steady increase in diseases associated with the human papillomavirus (HPV). The prevalence of human papillomavirus infection of the genitals in the world has increased more than 10 times, it is found in 13 % of the population. Cervical cancer remains one of the most common forms of HPV-associated malignancy in women. About 570 thousand new cases of cervical cancer are diagnosed in the world every year, while the increase in incidence over the past 10 years was 7.8 %, and mortality was 13.1 %. In recent years, scientists have paid close attention to the study of assessing the effect of HPV on the endometrium and the degree of its participation in the development of GGE. From the standpoint of the latest scientific data, the generality of the influence of HPV on any epithelium should be considered through the prism of squamous cell metaplasia. Currently, there are still many unsolved scientific and practical issues, primarily related to the regional characteristics of the prevalence of various types of HPV, which determines the direction of cervical screening, as well as clinical manifestations during coinfection, dictating the need for a differentiated approach to patient management tactics.Conclusion. A review of modern literature data indicates that most studies on various aspects of the influence of HPV on the reproductive health of women remain the subject of discussion, which dictates the need for further research.
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