No abstract
Serum alanine aminotransferase, aspartate aminotransferase and -glutamyltransferase activities were monitored in psychiatric patients receiving normal doses of phenothiazine neuroleptics over a 30-day period. The first two enzymes showed slight initial increases and a subsequent return to normal, while the third showed a slight increase. In rats, dosage levels exceeding those used in human therapy produced much larger increases in the catalytic concentrations of all three enzymes in serum (1.4, 0.7 and 0.5 above the control value, respectively), and somewhat smaller increases in the liver homogenates of these animals. Wirkung neuroleptischer Phenothiazine auf die Aktivitäten von Aminotransferasen und y-Glutamyltransferase in Serum und LeberZusammenfassung: In Seren von geisteskranken Patienten wurden die Aktivitäten von Aspartataminotransferase, Alaninaminotransferase und -Glutamyltransferase während einer dreißigtägigen Therapie mit Phenothiazinen bestimmt. Die Änderungen in den Aktivitäten aller drei Enzyme bewegten sich etwa in dem breiteren Grenzbereich der i Referenzwerte.Experimente mit Ratten und größeren Dosen von Arzneimitteln haben signifikante Änderungen in den Enzymaktivitäten gezeigt: die Aktivitäten von Aspartataminotransferase waren bis zu l ,4, von Alaninaminotransferase 0,7 und von -Glutamyltransferase 0,5 mal höher als die Referenzwerte.
The relationship between glycosaminoglycans and β2-microglobulin, glycosaminoglycans and N-acetyl-β-D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in order to establish a method for early detection of this disease. The results show an unquestionable increase in urinary excretion of total glycosaminoglycans in subjects with or suspected of having Balkan endemic nephropathy while the chondroitin sulfate/heparan sulfate ratio was not statistically different between the groups studied. Thus, the chondroitin sulfate/heparan sulfate ratio cannot be used as a cheap and quick semiquantitative method for the diagnosis of early tubular damage in Balkan endemic nephropathy. However, the determination of total glycosaminoglycans in the urine of subjects from endemic areas proved to be valuable additional information helping with the diagnosis of Balkan endemic nephropathy.
Juretio, Lipovac, Hadzija and Slijepcevio: Glycosidases-hyperglycaemia relationships in rat kidney (urine) 21 Summary: The catalytic activities of N-acetyl-ß-D-glucosaminidase % , ß-galactosidase and -glucosidase in kidney and urine of diabetic rats were investigated in relation to the duration of diabetes, to the degree of constant hyperglycaemia and to the therapeutic control in the early stage of disease.The results suggest that the degree of constant hyperglycaemia and the duration of untreated diabetes are significant determining factors for the course of morphological changes. These changes are manifested äs a decrease of the glycosidases in kidney (0.5 to 0.6 time the age-matched controls) and äs moderate to severe enzymurias.Daily Variation of blood glucose with inadequate insulin Lente therapy caused decreased N-acetyl-ß-Dglucosaminidase and ß-galactosidase activities in kidney äs well äs enzymuria. Since such changes can be correlated with histologically visible changes in the kidney, the measurement of these enzymes in urine is a simple way of monitoring the development of kidney damage in poorly controlled diabetes.When constant normöglycaemia was maintained for three weeks with insulin Ultralente in diabetic rats with a confirmed decrease of kidney glycosidases, the persisting morphological alteration of the organ was reflected by a urinary Output of N^acetyl-ß-D-glucosaminidase. Einfluß des Hyperglykämie-Grades auf die katalytischen Aktivitäten von Glykosidasen in Nieren und Harn diabetischer RattenZusammenfassung: Die katalytisehen Aktivitäten von N-Acetyl-ß-D-glucosaminidase, ß-Galaktosidase und -Glucosidase in Niere und Harn diabetischer Ratten wurden untersucht und in Beziehung gesetzt zur Dauer des Diabetes, zum Grad einer konstanten Hyperglykämie und zur therapeutischen Kontrolle im Früh-stadium der Erkrankung.Die Ergebnisse weisen darauf hin, daß der Grad konstanter Hyperglykämie und die Dauer eines unbehandelten Diabetes bedeutende Einflußgrößen für den Ablauf morphologischer Veränderungen sind. Die Verän-derungen werden manifest als Abfall der Glykosidasen in der Niere auf das 0,5-0,6-fache gleichaltriger Kontrollen und als mäßige bis starke Enzymurien.Tägliche Änderung der Glucosekonzentration im Blut durch inadäquate Therapie mit Insulin Lente bewirkte erniedrigte katalytische Aktivitäten von N-Acetyl-ß-D-glucosaminidase und ß-Galaktosidase in der Niere als auch Enzymurie. Da solche Änderungen mit histologisch sichtbaren in der Niere korreliert werden können, ist die Bestimmung dieser Enzyme im Harn ein einfacher Weg, die Entwicklung eines Nierenschadens bei schlecht kontrolliertem Diabetes zu verfolgen. J. Clin. Chem. Clin. Biochem. / Vol. 22,1984 / No. l Brought to you by | University of Arizona Authenticated Download Date | 7/11/15 1:17 AM 22Jurctic, Lipovac, Hadzija and Slijepcevio: Glycosidases-hyperglycaemia relationships in rat kidney (urine) Wenn bei diabetischen Ratten mit einem bestätigtem Abfall der Glykosidasen in der Niere für 3 Wochen eine konstante Normoglykämie durch I...
Liver and brain cortex slices from rats made hyperphenylalaninaemic with p-chlorophenylalanine showed decreased leucine uptake but increased uptake of tryptophan and glycine.
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