Purpose: Worldwide prevalence of diabetes mellitus (DM) has become an issue of great concern in current decades. To date, a large number of biological properties have been reported from carotenoids, particularly protective effects against cancer, cardiovascular diseases, and DM, including enhancement of insulin sensitivity.In this study, we aimed to evaluate the efficacy of β-carotene as an additive agent with metformin in ameliorating Type2 (T2)DM. Methods: In this experiment, fasting blood glucose level (BGL), low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC) and triglycerides (TG) were measured in serum of Wister albino rats with streptozotocin (STZ)-induced diabetes and after treatment with metformin (850mg/70kg b.w.) and β-carotene (10 mg/70kg b.w.) administered orally once daily for three weeks. Results: Metformin and β-carotene treatments individually resulted in significant (p<0.001) reversal of the diabetes induced increase in BGL, LDL, TC and TG, whereas significantly increased the STZ-induced decrease in HDL, compared to diabetic control. As compared to the monotherapy, the combination therapy with metformin and β-carotene showed a significant (p<0.001) attenuation of BGL and serum level of LDL, TC, and TG and a slight increase (p<0.05) in serum HDL level, as compared to the treatment with β-carotene, but not with metformin. Conclusion: The combination therapy of β-carotene and metformin produced a significant antidiabetic and antihyperlipidemic effect than the monotherapy alone and provides a scientific rationale for their use in antidiabetic therapy as a potential antioxidant.
Objective: A vital anti-oxidant, β-carotene has the capacity to reduce reactive oxidative stress, metabolic syndrome such as Type 2 (T2) Diabetes Mellitus (DM) and prevent inflammation, obesity, alzheimer and cardiovascular diseases in human. In this study, we evaluated the efficacy of β-carotene on streptozotocin (STZ)- induced T2DM rats. Methods: Diabetes was induced in Wister rats through the intraperitoneal administration of STZ (50 mg/kg b.w.). Antihyperlipidemic activities of β-carotene were evaluated by oral dose (10 mg/70 kg b.w.) once daily for 21 days. Metformin (12.1 mg/kg b.w.) was used as a positive control. Results: Blood samples of rats were drawn by tail vein puncture and cardiac puncture to determine the fasting blood glucose (FBG) and serum level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), respectively. The result of individual treatment of β-carotene and metformin significantly (p<0.001) reversed the diabetes induced increase in FBG, LDL, TC and TG, whereas pointedly increased the STZ-induced decrease in HDL, if compared to the diabetic control. Conclusion: The monotherapy of β-carotene had important antidiabetic and antihyperlipidemic effects and provided a scientific rationale for their use in antidiabetic therapy as a potential antioxidant.
Objectives: Piper chaba, native to South and Southeast Asia, has been traditionally used as a medicinal plant. Aim of this study was to evaluate the antihyperglycemic and antihyperlipidemic activities of P. chaba root extracts (RE) in streptozotocin (STZ)-induced diabetic rats along with its antimicrobial activity. Methods: Diabetes was induced in Wister rats through the intraperitoneal administration of STZ (50 mg/kg b.w.). Antidiabetic and antilipidemic activities of the RE (in methanol, ethanol, ethyl acetate and distilled water) were evaluated by administering oral dose (200 mg/kg b.w.) for 21 days. Metformin (12.1 mg/kg b.w.) was used as a positive control. Blood samples of rats were drawn by tail vein puncture and cardiac puncture to determine the fasting blood glucose (FBG) and serum level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), respectively. Standard protocols were followed to determine the antimicrobial and antibiofilm activities against two different strains of bacteria. Results: Oral administration of P. chaba RE for 21 days resulted in a significant (p< 0.001) decrease in FBG and TC, TG, and LDL levels (p<0.001), when compared to the untreated diabetic rats. Significant (p<0.001) increase of HDL was observed when ethyl acetate and aqueous RE were administered. Out of four, two extracts showed varying antimicrobial activities, particularly against the gram-positive bacteria. Conclusion: It became evident for the first time that P. chaba extracts possess antimicrobial activities and can serve as biochemical compounds with great alternative therapeutic potential in the management of diabetes and hypercholesterolemia.
Kikuchi’s disease is a rare, benign, self-limiting disorder, characterized clinically by fever and regional lymphadenopathy. Histopathologic features of lymph nodes in Kikuchi’s disease are characteristic and permit differentiation of this benign condition from lymphomas, systemic lupus erythematosus and infectious lymphadenopathies. We report a female patient presenting with fever and tender cervical lymphadenopathy. An excisional biopsy of the lymph node reveale lymphadenitis, consistent with Kikuchi’s disease.TAJ 2012; 25: 81-83
Introduction and objectives: A large proportion of patients with coronary disease have metabolic syndrome. The purpose of this research was to assess the association between the metabolic syndrome (MetS) and acute myocardial infarction in female patients.Methods: This was a case control study. Patients with a first time cardiac event of acute myocardial infarction (AMI) arriving in coronary care unit of Rajshahi Medical College Hospital, Rajshahi, Bangladesh during the period June 2013 to July 2014 were included. Metabolic syndrome and its five components were defined according to criteria set by Adult Treatment Plan III (NCEP ATP III) criteria. Blood sugars, triglycerides, HDL-C were measured within 24hrs of cardiac insult. Hypertension was defined as blood pressure ≥ 130/≥85 mmHg. Abdominal obesity measured by waist circumference which is defined for Asia-Pacific region as ≥ 80 cm for women.Results: Total 103 female patients were evaluated. Mean age was 54.28 ±11.78 and acute myocardial infarction was more in age group 50-59 (34%). More than 60% patients suffering from acute myocardial infarction was age group 40-60 years. The metabolic syndrome was present in 74 (71.8%) female patients with acute myocardial infarction and was more frequent in women than in men (71.8% vs 37.9%, P<.001). The most prevalent component was low HDL-C (n 76; 73.8%), followed by fasting plasma glucose level (n 73; 70.9%).Conclusions: The metabolic syndrome has a high prevalence in female patients with acute myocardial infarction. The most frequent components are low HDL-C levels and fasting plasma glucose level.TAJ 2013; 26: 74-78
This cross sectional descriptive study was conducted to assess cytological characteristics of bronchial carcinoma in 60 patients from various region of Rajshahi Division presenting with clinical features consisting with the diagnosis of lung carcinoma. They were admitted to Rajshahi Medical College Hospital from January 2013 to December 2013. Our observations reveals that the most prevalent malignancy among these patients was non small cell lung carcinoma including squamous cell carcinoma and large cell carcinoma in males patients. The common site of bronchial carcinoma in the upper lobe of lung. The proper treatment of bronchial carcinoma depends on the cytological pattern of bronchial carcinoma.TAJ 2013; 26: 27-29
HbE is the most common abnormal hemoglobin of Southeast Asia and is almost limited to this region. It is estimated that 30 million people are heterozygous for HbE and that 1 million are homozygous. Aim of this study was to know the number of homozygous for haemoglobin E condition (Hb E disease) patients among patients suspected of having hereditary haemoglobin disorders referred to the regional laboratory, in Rajshahi. From April 2009 to March 2012, anaemic patients suspected of having hereditary haemoglobin disorder (haemoglobinopathy or thalassemia) were referred to the divisional laboratory, Rajshahi for hemoglobin electrophoresis from the physicians of different areas of Rajshahi division and part of Khulna division. Patient’s age ranging from 01 to 85 yrs of both sexes. Two to three milliliter blood was collected in tubes containing EDTA for complete blood count (CBC) and analysis of hemoglobin variants. CBC was measured by the Erma PC 604 particle counter. Peripheral blood film were examined after staining with Wright’s stain.9 Hemoglobin electrophoresis was carried out on cellulose acetate using TEB buffer, pH 8.6.9. Of 707 anaemic patients suspected of having hereditary haemoglobin disorder (haemoglobinopathy or thalassemia) 333 (47%) were abnormal. Of this abnormal patients 35 (11%) revealed a thalassemia-like disorder, 53 ( 17%) patients revealed haemglobin E disease, 46 ( 14%) patients haemglobin E trait and 188 ( 57%) patients having double heterozygous (Hb E/β thalassemia) disorder. The birth incidence for homozygous babies and or Eβ thalassemia would be increases per year. Population groups with higher frequencies require screening programmes and facilities for antenatal diagnosis. Future comprehensive study are require to know the actual prevalence. TAJ 2011; 24(1): 34-37
Breast cancer is the second common cause of cancer death in women of our country. Treatment of breast cancer depends on a number of parameters known as pathological and biological prognostic markers. Knowledge of the tumour grade would avoid under treatment of high grade carcinomas and over treatment of low grade carcinomas. Out study evaluated the feasibility of a grading system on FNA of duct cell carcinoma (NOS) and its ability to predict the histologic grade of the surgical specimens. The two widely practice grading system; Robinson’s cytological grading and Scraff Bloom Richardson histological grading system were utilized for this purpose. Various reports quote varied reproducibility, ranging from 50 to 90% correlation between histologic and cytologic grade. In this study, the correlation between histologic and cytologic grade is 86.3%. In this study association between grading by FNAC and histology was statistically highly significant (χ2=27.66, df=1, p<0.05) sensitivity 100% and specificity 58.33%. Maximum correlation was noted in grade-I. Out of 53 cases 46 showed correlation between histologic and cytologic grading, only 7 cases showed no correlation. Histologic grade were higher than cytologic grade and maximum were within one grade difference. The reasons for discrepancies between cytologic and histologic grades appear to be due to lack of histologic parameter of mitosis in cytology. In this study, a total 57 cases of breast lump were selected for FNAC; of them 56 were female and 1 male. Out of 57 cases, 44 cases had duct cell carcinoma (DCC) and 13 cases had atypical finding such as small cells, inconspicuous nucleoli. Fifty three cases were diagnosed as DCC and lobular carcinoma by histopathological study. After confirmation of the diagnosis of breast cancer by histopathological examination ER, PR determination by immunohistochemistry was done in all 53 cases of breast cancer. FNAC has good sensitivity (85.29%) and very high specificity (100%). It can replace the open biopsy in the majority cases of clinically malignant disease. TAJ 2018; 31(1): 1-8
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