Lesions induced by aspirin in the small intestine of the rat were visualized after 4 hours by the intravenous administration of a 5 percent solution of pontamine sky blue, 6 BX dye. Dose-response curves in fasted and fed rats indicated that the fed rat was about eight times more susceptible to aspirin-induced intestinal damage than was the fasted rat, while the fasted rat was about 13 times more susceptible to aspirin-induced gastric damage than was the fed rat.
The effect of 6 vasodepressors and 4 vasopressors was studied on cold + restraint-induced gastric hemorrhage in the rat. Significant reduction in hemorrhage incidence was produced by all the vasodepressors except methacholine; only clonidine of the vasopressors was effective in reducing the incidence of stress hemorrhage. A synergistic effect was found between vasopressin, angiotensin and norepinephrine and the individual stresses of cold or restraint. All of the vasodepressors and vasopressors reduced at least one parameter of gastric secretion in unstressed rats. No relationship was found between the effect of vasoactive drugs on stress-induced gastric hemorrhage and the degree of alteration of blood pressure.
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