The Effect of Vasoactive Agents on Stress-Induced Gastric Hemorrhage in the Rat

Hooke, K F

doi:10.1159/000197120

Cited by 37 publications

(11 citation statements)

References 9 publications

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“…The gastric juice contents of each animal were then centrifuged and the following parameters were assessed in the supernatants: The acid output: acid output was calculated according to the method by Brodie and Hooke . The acidity of the collected gastric juice was determined by titration to pH 7.0 with 0.01N NaOH.…”

Section: Methodsmentioning

confidence: 99%

“…The acid output: acid output was calculated according to the method by Brodie and Hooke . The acidity of the collected gastric juice was determined by titration to pH 7.0 with 0.01N NaOH.…”

Section: Methodsmentioning

confidence: 99%

“…a) The acid output: acid output was calculated according to the method by Brodie and Hooke. [13] The acidity of the collected gastric juice was determined by titration to pH 7.0 with 0.01N NaOH. Gastric acid output (volume × acidity) was expressed as microquivalents per 4 h. Stomachs were inspected for the presence of mucosal lesions.…”

Section: Assessment Of Gastric Acid Secretionmentioning

confidence: 99%

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Modulation of gastric acid secretion by cannabinoids in rats

Salama

Abdelsalam

Abdel-Salam

et al. 2018

J Biochem & Molecular Tox

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The current study aimed to evaluate the role of cannabinoid receptors in the regulation of gastric acid secretion and oxidative stress in gastric mucosa. To fulfill this aim, gastric acid secretion stimulated with histamine (5 mg/kg, subcutaneous [SC]), 2‐deoxy‐ d‐glucose (D‐G) (200 mg/kg, intravenous) or ‐carbachol (4 μg/kg, SC) in the 4‐hour pylorus‐ligated rats. The CB1R agonist ( N‐arachidonoyl dopamine, 1 mg/kg, SC) inhibited gastric acid secretion stimulated by D‐G and carbachol but not in histamine, reduced pepsin content, and increased mucin secretion. Furthermore, it decreased malondialdehyde (MDA) and nitric oxide (NO) contents with an increase in glutathione (GSH) and paraoxonase 1 (PON‐1). Meanwhile, CB2R antagonist (AM630, 1 mg/kg, SC) inhibited gastric acid secretion stimulated by D‐G and reduced MDA and NO contents with an increase in GSH and PON‐1. Meanwhile, CB1R antagonist rimonabant or CB2R agonist GW 405833 had no effect on stimulated gastric acid secretion. Therefore, both CB1R agonist and CB2R antagonist may exert antisecretory and antioxidant potential in the stomach.

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Section: Methodsmentioning

confidence: 99%

“…The acid output: acid output was calculated according to the method by Brodie and Hooke . The acidity of the collected gastric juice was determined by titration to pH 7.0 with 0.01N NaOH.…”

Section: Methodsmentioning

confidence: 99%

Section: Assessment Of Gastric Acid Secretionmentioning

confidence: 99%

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Modulation of gastric acid secretion by cannabinoids in rats

Salama

Abdelsalam

Abdel-Salam

et al. 2018

J Biochem & Molecular Tox

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“…Titratable acid output was calculated as µ-equivalents, by multiplying the volume in ml by the acid concentration in m-equivalent per liter (Brodie and Hooke, 1971). The results were then divided by four to give output per hour.…”

Section: Methodsmentioning

confidence: 99%

Induced Secretion Of Pepsin-Rich Gastric Juice In The Rat By The Crude Extract From <i>Elaeophorbia drupifera</i> Leaves: A Dual Pathway Mechanism

et al. 2005

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Summary: Ninety male white Wistar rats (200 -320g) were fasted for 48 hours, and used in the experiments for the collection of gastric juice according to the method of Shay et al, 1954. The extract (2.5 -200 mg/kg) increased the secretion of gastric juice which was low in volume but rich in pepsin concentration.The adrenergic drugs dihydroergoergotoxine (hydergine) (1.25 mg/kg) and phentolamine (1.5 mg/kg) both also increased gastric secretion, which were high in volume, titratable acidity and total acid output but low in pepsin concentration. When the extract (20 mg/kg) was given in combination with either of the two sympatholytic drugs, the pepsin concentration in the juice was richer than that evoked by either of the two drugs alone. Also, atropine-extract combination significantly (P<0.01) increased gastric juice secretion when compared to that produced by atropine alone. Similar increase in acid secretion was observed when cimetidine-extract combination was administered and compared to that produced by cimetidine alone. We suggest a dual pathway mechanism of action for the E. drupifera leaf extract-induced secretion of gastric juice. One of which may be mediated by the muscarinic cholinoceptors and the other via histamine H 2 -receptor subtype.

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“…Titratable acidity was carried out according to the method of [25] and [26] by titrating gastric juice against sodium hydroxide (0.01N) using phenol red as an indicator. Acid output was calculated as the rate of the gastric juice production [27] as microequivalents per 4 hours.…”

Section: Gastric Volume Titratable Acidity and Acid Output Determinmentioning

confidence: 99%

Comparison between the Protective Effects of Famotidine, Ginger and Marshmallow on Pyloric Ligation-Induced Peptic Ulcer in Rats

Ss¹,

Ba²,

Aa³

et al. 2015

J Bioequiv Availab

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The Effect of Vasoactive Agents on Stress-Induced Gastric Hemorrhage in the Rat

Cited by 37 publications

References 9 publications

Modulation of gastric acid secretion by cannabinoids in rats

Modulation of gastric acid secretion by cannabinoids in rats

Induced Secretion Of Pepsin-Rich Gastric Juice In The Rat By The Crude Extract From <i>Elaeophorbia drupifera</i> Leaves: A Dual Pathway Mechanism

Comparison between the Protective Effects of Famotidine, Ginger and Marshmallow on Pyloric Ligation-Induced Peptic Ulcer in Rats

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