Prognosis of oropharyngeal squamous cell carcinoma depends on early diagnosis, despite advanced surgical techniques, the 5-year survival rate remains ~40-50%. Unfortunately, it is usually detected when it becomes symptomatic. This requires treatment which gives rise to a high rate of morbidity and mortality and, furthermore, early detection of oro-pharyngeal pre-malignant lesions is important to improve the survival rate and quality of life. Since dysplasia and in situ carcinoma contain much more DNA and RNA than the normal surrounding epithelium, the use of in vivo staining, by means of toluidine blue dye, is based on the fact that it is an acidophilic dye that selectively stains acidic tissue components such as DNA and RNA. Toluidine blue staining is considered to be sensitive in identifying early oro-pharyngeal premalignant and malignant lesions. In the present study, the use of toluidine blue staining was taken into consideration to identify clinically doubtful oro-pharyngeal lesions and to compare toluidine blue stain and with the histological evaluation. Key words:Early detection, improved survival, pre-cancer, toluidine blue, vital staining.

IntroductionTo compare and evaluate clinically and radio-graphically the bone regeneration and the amount of bone fill in intrabony component of periodontal osseous defects through the osteoconductive and osteostimulative effect of bioactive synthetic NovaBone Putty - CMF and osteoconductive effect of calcified algae-derived porous hydroxyapatite Frios® Algi-pore® bone grafts.Materials and methodsTwenty-two sites in 11 patients, within the age range of 25 to 60 years, showing intrabony defects were selected according to split mouth design and divided into group I (Frios® Algipore®) and group II (NovaBone Putty - CMF). All the selected sites were assessed with the clinical and radiographic parameters like plaque index, gingival index (full mouth and site specific), sulcus bleeding index, probing pocket depth, clinical attachment level, gingival recession, and radiographic bone fill. All the clinical and radiographic parameter values obtained at different intervals (baseline, 3, and 6 months) were subjected to statistical analysis.ResultsA statistically significant reduction in pocket depth of 2.55 ± 0.52 mm (group I), 2.64 ± 0.67 mm (group II) and gain in clinical attachment level of 7.55 ± 1.44 mm (group I), 7.55 ± 2.38 mm (group II) were recorded at the end of the study. A slight increase in gingival recession was observed. The mean percentage change in amount of radiographic bone fill of group II (71.34%) was more than group I (61.93%).ConclusionBoth NovaBone Putty - CMF and Frios® Algipore® improve healing outcomes and lead to a reduction of probing depth, a resolution of osseous defects, and a gain in clinical attachment, but radiographic observation found better results with NovaBone Putty.How to cite this articleBembi NN, Bembi S, Mago J, Baweja GK, Baweja PS. Comparative Evaluation of Bioactive Synthetic NovaBone Putty and Calcified Algae-derived Porous Hydroxyapatite Bone Grafts for the Treatment of Intrabony Defects. Int J Clin Pediatr Dent 2016;9(4):285-290.

Aim This study aimed to evaluate the potential usefulness of Chat Generated Pre-Trained Transformer-3 (ChatGPT-3) in oral and maxillofacial radiology for report writing by identifying radiographic anatomical landmarks and learning about oral and maxillofacial pathologies and their radiographic features. The study also aimed to evaluate the performance of ChatGPT-3 and its usage in oral and maxillofacial radiology training. Materials and methods A questionnaire consisting of 80 questions was queried on the OpenAI app ChatGPT-3. The questions were stratified based on three categories. The categorization was based on random anatomical landmarks, oral and maxillofacial pathologies, and the radiographic features of some of these pathologies. One oral and maxillofacial radiologist evaluated queries that were answered by the ChatGPT-3 model and rated them on a 4-point, modified Likert scale. The post-survey analysis for the performance of ChatGPT-3 was based on the Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis, its application in oral and maxillofacial radiology training, and its recommended use. Results In order of efficiency, Chat GPT-3 gave 100% accuracy in describing radiographic landmarks. However, the content of the oral and maxillofacial pathologies was limited to major or characteristic radiographic features. The mean scores for the queries related to the anatomic landmarks, oral and maxillofacial pathologies, and radiographic features of the oral and maxillofacial pathologies were 3.94, 3.85, and 3.96, respectively. However, the median and mode scores were 4 and were similar to all categories. The data for the oral and maxillofacial pathologies when the questions were not specifically included in the format of the introduction of the pathology, causes, symptoms, and treatment. Out of two abbreviations, one was not answered correctly. Conclusion The study showed that ChatGPT-3 is efficient in describing the pathology, characteristic radiographic features, and describing anatomical landmarks. ChatGPT-3 can be used as an adjunct when an oral radiologist needs additional information on any pathology, however, it cannot be the mainstay for reference. ChatGPT-3 is less detail-oriented, and the data has a risk of infodemics and the possibility of medical errors. However, Chat GPT-3 can be an excellent tool in helping the community in increasing the knowledge and awareness of various pathologies and decreasing the anxiety of the patients while dental healthcare professionals formulate an appropriate treatment plan.

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