Corticosteroids in dentistry

Bhanot, Rishu; Mago, Jyoti

doi:10.4103/0976-4003.196814

Cited by 5 publications

(5 citation statements)

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“…10 The most important uses of corticosteroids in dentistry include treatment of Oral diseases such as (Recurrent aphthous stomatitis, oral lichen planus, erythema multiforme, pemphigus vulgaris, Behcet's disease, central giant cell granuloma, it also has significant uses in endodontics (reduction in pulpal inflammation), orthodontics and oral surgery (After oral surgical procedures, steroids are administered to reduce edema and inflammation) and treatment of Anaphylaxis. 12,13,14 The oral side effects associated with the use Corticosteroids are numerous, some of the most common include swellings, bruising and slower wound healing due to the disruption of normal healing mechanisms which involve interference with inflammation, fibroblast proliferation, collagen synthesis and degradation, angiogenesis, wound contraction, and re-epithelialization. There is Increased risk of infections particularly oral candidiasis, due to their immunosuppressive effect.…”

Section: Steroidalmentioning

confidence: 99%

Side Effects of Steroidal and Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity.

Ghazi,

Rasul,

Hamad

et al. 2024

EDJ

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Background and objectives: The steroidal and Non-Steroidal Anti-Inflammatory drugs (NSAIDs) are widely used classes of medications for their anti-inflammatory and analgesic effects and are associated with the risk of many oral side effects and which might be presented with variable degrees of severity. The main objective of this research was to identify oral side effects that could be associated with using Steroidal or NSAIDs. Patients and Methods: A total number of 82 patients who were attending the teaching clinics at the College of Dentistry and were using steroids or NSAIDs participated in this study and they were interviewed and examined clinically for the presence of any abnormal oral presentation. The data were all recorded on a pre-designed questionnaire. The data was expressed as a percentage and analyzed statistically using ANOVA and t-test. Results: The data showed that a majority of NSAIDs users complained of gingival bleeding (39%) and Xerostomia (32%), while corticosteroid users complained of fungal infection (50%), gingival inflammation (25%) and other less frequent side effects. Drugs that were associated with the most oral side effects were aspirin, ibuprofen, mefenamic acid and prednisolone. Conclusion: Data analysis showed that many oral side effects might be related to steroidal and NSAIDs. It is important to consider that drugs in general may cause oral side effects at different doses, dosage forms and durations of use and may have a variety of clinical presentation. The dentists have a crucial role in identifying these drug-related oral side effects through their clinical practices in order to provide the proper management for the patients. Keywords: Side effects, steroids, NSAIDs, xerostomia, Ulcers.

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Section: Steroidalmentioning

confidence: 99%

Side Effects of Steroidal and Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity.

Ghazi,

Rasul,

Hamad

et al. 2024

EDJ

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“…A brief course of systemic glucocorticoids could be used to treat moderate to severe (7) cases of EM. Systemic prednisone 0.5-1.0 mg/kg/day or pulse methylprednisolone 1 mg/kg/day for 3 days are the two main forms of initial treatment, 3 consecutive daily infusions of (9) 20-30 mg/kg to a maximum of 500 mg. Topical steroids - (9) triamcinolone, fluocinonide, and clobetasol propionate.…”

Section: Er Ythema Multifor Mementioning

confidence: 99%

Immunomodulators in Dentistry, an Updated Review

Deivanayagi

2023

PIJR

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Immunity plays a vital role in maintaining the health of an individual. Immunomodulators are a class of drugs that maintain the homeostasis of the immune system when it is altered by any disease.The immunity can be either improved or suppressed with immunostimulants and immunosuppressant respectively. These drugs are inevitably used in the treatment of various oral diseases.This review article focuses on the various immunomodulators used in dentistry.

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“…It should be noted that this route of administration comes with warnings, as the continuous use of dexamethasone can cause Cushing's syndrome [46]. In 1974, Hooley and Hohl concluded that the topical use of steroids prevents ulceration and excoriation or the chafing that results from the reduction in tissue on the lips or corners of the mouth [47].…”

Section: Parenteral Routementioning

confidence: 99%

Efficacy/Safety of the Use of Glucocorticoids in Oral and Maxillofacial Surgery

Nils,

Arce Recatala,

Castano

et al. 2023

Dentistry Journal

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Introduction: Glucocorticoids, also known as corticosteroids or steroids, are drugs derived from cholesterol. They are synthesized by the adrenal cortex, along with other hormones, such as cortisol and aldosterone. Glucocorticoids are drugs recommended for patients undergoing surgery on the oral cavity, facial skeleton, and related cervical structures due to their high efficacy against inflammatory and immune processes. However, these drugs are restricted due to their multiple and serious adverse effects. The objective of this study was to verify the efficacy of corticosteroids administered in major surgeries of the oral cavity, as well as of the cervical and facial structures, based on the characteristics of the patient so as to select the best therapeutic strategy. Methods: Articles in the databases of PubMed, Nature Portfolio, Medline, Cochrane Library, and Google Scholar were thoroughly examined. Results: A total of 54 articles were selected to address the proposed objectives. The results obtained show that it is effective and safe to use glucocorticoids as pre- or postsurgical therapy in oral and maxillofacial surgery to control the processes of inflammation, pain, lockjaw, and edema. However, when referring to the use of these drugs, one must proceed with caution and pay particular attention when handling them. The concentration of the glucocorticoids used must be individualized, as well as the selection of the route of administration. Various studies show that, although the oral route is the most used route, the most effective route is the intramuscular route due to its easy absorption. However, for patients who have recurrent inflammatory and vesiculobullous ulcerative lesions, the topical route should be chosen to mitigate side effects, considering that recurrent applications must be made to prevent the worsening of the lesion and to avoid having to use medications enterally. In patients with cervicofacial infections, antibiotics continue to be the main drugs used to manage the condition in conjunction with corticosteroids. It is important to know the possible interactions of glucocorticoids with other medicines or food: it has been described that the interaction between Ritonavir, an antiretroviral drug that inhibits human immunodeficiency virus (HIV) proteases, and prednisone causes an increase in the concentration of prednisone, leading to possible toxicity in normally safe doses and, in many cases, iatrogenic Cushing’s syndrome. It is also important to know the systemic or topical adverse effects of the chronic or high-dose use of glucocorticoids. Conclusions: It can be concluded that by making adequate use of glucocorticoid therapy in oral and maxillofacial surgery to manage clinical manifestations, it is possible to attenuate the morbidities of treatment and intervention.

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Corticosteroids in dentistry

Cited by 5 publications

References 0 publications

Side Effects of Steroidal and Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity.

Side Effects of Steroidal and Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity.

Immunomodulators in Dentistry, an Updated Review

Efficacy/Safety of the Use of Glucocorticoids in Oral and Maxillofacial Surgery

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