Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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Abstract. The Global Navigation Satellite System (GNSS) Occultation Sounder (GNOS) is one of the new-generation payloads on board the Chinese FengYun 3 (FY-3) series of operational meteorological satellites for sounding the Earth's neutral atmosphere and ionosphere. FY-3C GNOS, on board the FY-3 series C satellite launched in September 2013, was designed to acquire setting and rising radio occultation (RO) data by using GNSS signals from both the Chinese BeiDou Navigation Satellite System (BDS) and the US Global Positioning System (GPS). So far, the GNOS measurements and atmospheric and ionospheric data products have been validated and evaluated and then been used for atmosphere- and ionosphere-related scientific applications. This paper reviews the FY-3C GNOS instrument, RO data processing, data quality evaluation, and preliminary research applications according to the state-of-the-art status of the FY-3C GNOS mission and related publications. The reviewed data validation and application results demonstrate that the FY-3C GNOS mission can provide accurate and precise atmospheric and ionospheric GNSS (i.e., GPS and BDS) RO profiles for numerical weather prediction (NWP), global climate monitoring (GCM), and space weather research (SWR). The performance of the FY-3C GNOS product quality evaluation and scientific applications establishes confidence that the GNOS data from the series of FY-3 satellites will provide important contributions to NWP, GCM, and SWR scientific communities.

Abstract. The Global Navigation Satellite System (GNSS) Occultation Sounder (GNOS) is one of the new-generation payloads onboard the Chinese FengYun 3 (FY-3) series of operational meteorological satellites for sounding the Earth's neutral atmosphere and ionosphere. The GNOS was designed for acquiring setting and rising radio occultation (RO) data by using GNSS signals from both the Chinese BeiDou System (BDS) and the US Global Positioning System (GPS). An ultra-stable oscillator with 1 s stability (Allan deviation) at the level of 10 −12 was installed on the FY-3C GNOS, and thus both zero-difference and singledifference excess phase processing methods should be feasible for FY-3C GNOS observations. In this study we focus on evaluating zero-difference processing of BDS RO data vs. single-difference processing, in order to investigate the zero-difference feasibility for this new instrument, which after its launch in September 2013 started to use BDS signals from five geostationary orbit (GEO) satellites, five inclined geosynchronous orbit (IGSO) satellites and four medium Earth orbit (MEO) satellites. We used a 3-month set of GNOS BDS RO data (October to December 2013) for the evaluation and compared atmospheric bending angle and refractivity profiles, derived from single-and zero-difference excess phase data, against co-located profiles from European Centre for Medium-Range Weather Forecasts (ECMWF) analyses. We also compared against co-located refractivity profiles from radiosondes. The statistical evaluation against these reference data shows that the results from single-and zero-difference processing are reasonably consistent in both bias and standard deviation, clearly demonstrating the feasibility of zero differencing for GNOS BDS RO observations. The average bias (and standard deviation) of the bending angle and refractivity profiles were found to be about 0.05 to 0.2 % (and 0.7 to 1.6 %) over the upper troposphere and lower stratosphere. Zero differencing was found to perform slightly better, as may be expected from its lower vulnerability to noise. The validation results indicate that GNOS can provide, on top of GPS RO profiles, accurate and precise BDS RO profiles both from single-and zero-difference processing. The GNOS observations by the series of FY-3 satellites are thus expected to provide important contributions to numerical weather prediction and global climate change analysis.

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Abstract.14 The rapid advancement of global navigation satellite system (GNSS) occultation technology in recent years has 15 made it one of the most advanced space detection technologies of the 21st century. GNSS radio occultation has 16 many advantages, including all-weather operation, global coverage, high vertical resolution, high precision, 17 long-term stability, and self-calibration. Data products from GNSS occultation sounding can greatly enhance 18 ionospheric observations and contribute to space weather monitoring, forecasting, modeling, and research. In this 19 study, GNSS occultation sounder (GNOS) results from a radio occultation sounding payload aboard the Fengyun 20 3-C (FY3-C) satellite were compared with ground-based ionosonde observations. Correlation coefficients for 21 peak electron density (NmF2) derived from GNOS Global Position System (GPS) and Beidou navigation system 22 (BDS) products with ionosonde data were higher than 0.9, and standard deviations were less than 20 %. Global 23 ionospheric effects of the strong magnetic storm event in March 2015 were analyzed using GNOS results 24supported by ionosonde observations. The magnetic storm caused a significant disturbance in NmF2 and hmF2 25 levels. Suppressed daytime and nighttime NmF2 levels indicated mainly negative storm conditions. In the zone 26 of geomagnetic inclination between 40-80°, average NmF2 during the geomagnetic storm showed the same 27 basic trends in GNOS measurements, and in observations from 17 ground-based ionosonde stations, and 28 confirmed the negative effect of the event on the ionosphere. The analysis demonstrates the reliability of the 29 GNSS radio occultation sounding instrument GNOS aboard the FY3-C satellite, and confirms the utility of 30 ionosphere products from GNOS for statistical and event-specific ionospheric physical analyses. Future FY3

Soil moisture is the most active part of the terrestrial water cycle, and it is a key variable that affects hydrological, bio-ecological, and bio-geochemical processes. Microwave remote sensing is an effective means of monitoring soil moisture, but the existing conventional radiometers and single-station radars cannot meet the scientific needs in terms of temporal and spatial resolution. The emergence of GNSS-R (Global Navigation Satellite Systems Reflectometry) technology provides an alternative method with high temporal and spatial resolution. An important application field of GNSS-R is soil moisture monitoring, but it is still in the initial stage of research, and there are many uncertainties and open issues. Based on a review of the current state-of-the-art of soil moisture retrieval using GNSS-R, this paper points out the limitations of existing research in observation geometry, polarization, and coherent and non-coherent scattering. The smooth surface reflectivity model, the random rough surface scattering model, and the first-order radiation transfer equation model of the vegetation, which are in the form of bistatic and full polarization, are employed. Simulations and analyses of polarization, observation geometry (scattering zenith angle and scattering azimuth angle), Brewster angle, coherent and non-coherent component, surface roughness, and vegetation effects are carried out. The influence of the EIRP (Effective Isotropic Radiated Power) and the RFI (Radio Frequency Interference) on soil moisture retrieval is briefly discussed. Several important development directions for space-borne GNSS-R soil moisture retrieval are pointed out in detail based on the microwave scattering model.