Cd is a highly detrimental global environmental pollutant. Plants have evolved complex defense mechanisms as an adaptation to against Cd toxicity. In this study, a pot experiment was performed to evaluate the protein profile of saffron in response to Cd stress. Fifteen proteins were found to be up-regulated in the leaves of plants under Cd stress and were primarily related to metabolism, signal transduction, stress and defense response and energy. Eleven proteins were found to be down-regulated following Cd treatment, including ribulose bisphosphate carboxylase/oxygenase (Rubisco), ferredoxin-NADP reductase, a 70 kDa heat shock-related protein and three protein synthesis-associated proteins. The results provide valuable insights regarding the molecular mechanism of saffron in response to Cd toxicity and the possible utilization of genetic resources in developing Cd tolerant/low-accumulation saffron.
Introduction:The purpose of this trial was to determine the efficacy of a Nurse Controlled Analgesia (NCA) protocol in reducing the time taken to achieve a satisfactory postoperative pain score. The safety aspects of the NCA protocol were also evaluated.
In this study, after optimizing the extraction process of CPP ( Codonopsis pilosula polysaccharides), CPPM (CPP microcapsules) were prepared. Subsequently, the structural characteristics and physicochemical properties were studied. The results showed that CPPM is a hollow sac-like structure with rough folds and protuberances and comes in spherical or ellipsoidal shapes with uniform particle size. CPPM has certain swelling degree, low hardness, good adhesion, and stability. Then, the effect of CPPM on wounds repair was investigated by a rat model. The results showed that CPPM could improve the wound healing rate. Histological evaluation showed CPPM could promote neovascularization and fibroblast proliferation. By investigating the healing mechanism, it was found that CPPM increased the hydroxyproline content in granulation tissue and had an excellent antioxidant ability, and then inhibited lipid peroxidation, in addition, it significantly increased the transcript levels of VEGF and miRNA-21 genes, indicating that CPPM play an influential role in vascular remodeling during wound healing by up-regulating the expression of VEGF and miRNA-21 genes.
Background:
Obesity commonly affects postsurgical pulmonary outcomes and is associated with increased oxygen usage, length of recovery and hospital stay, discharge to high levels of care, cost, morbidity, and mortality.
Local Problem:
No standardized pulmonary care bundle for obese patients after bariatric surgery was available in the postanesthesia care unit (PACU) at a hospital in Singapore.
Methods:
This quality improvement project was a prospective, single-cohort, pre- and posttest intervention design with 151 patients recruited.
Interventions:
Teaching and implementation of a modified nurse-led COUGH bundle was carried out on obese patients after their bariatric surgery.
Results:
Postbariatric surgery patients with the nurse-led COUGH bundle had significantly less consumption of oxygen in the PACU and step-down units. The PACU and hospital length of stay were also reduced.
Conclusions:
The modified nurse-led COUGH bundle can reduce patients' oxygen usage and hospital stay after their bariatric surgery.
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