Preparation of <i>Codonopsis pilosula</i> polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats

Yang, Ming; Jin, Yongming; Yang, Jumei; Wang, Chenliang; Wang, Xinjian; Wang, Yonggang

doi:10.1177/08853282211054333

Cited by 4 publications

(2 citation statements)

References 61 publications

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“…The prepared probiotic double-layered multinucleated microcapsules were placed in the collection tube, and their particle size distribution was analyzed by laser light scattering (JB6100-C, Shanghai Jiubin Instrument, CHN). 28 2.11.3.2. Morphology Observations of Microcapsules.…”

Section: Preparation Of Probiotic Microcapsules 2111 Preparation Of I...mentioning

confidence: 99%

Construction of Probiotic Double-Layered Multinucleated Microcapsules Based on Sulfhydryl-Modified Carboxymethyl Cellulose Sodium for Increased Intestinal Adhesion of Probiotics and Therapy for Intestinal Inflammation Induced by Escherichia coli O157:H7

Zhang

Liu

Fang

et al. 2023

ACS Appl. Mater. Interfaces

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The decreased number of viable bacteria and the ability of Bifidobacterium to adhere to and colonize the gut in the gastrointestinal environment greatly limit their efficacy. To solve this problem, thiolated carboxymethyl cellulose sodium (CMC) probiotic double-layered multinucleated microcapsules with Bifidobacterium adolescentis FS2-3 in the inner layer and Bacillus subtilis SN15-2 embedded in the outer layers were designed. First, the viable counts and release rates of microcapsules were examined by in vitro simulated digestion assays, and it was found that microcapsules were better protected from gastrointestinal digestion than the controls. Compared with free Bifidobacterium strains, double-layered multinucleated microcapsules have higher viable bacterial survival rates and storage stability. Second, through in vitro rheology, tensile tests, isotherm titration calorimetry, and adhesion tests, it was observed that thiolated CMC could enhance the strong interaction of Bifidobacterium with intestinal mucus and significantly promote the proliferation and growth of probiotics. Finally, double-layered multinucleated microcapsules containing B. adolescentis FS2-3 and B. subtilis SN15-2 modified with sulfhydryl-modified CMC were studied in the intestine. Alleviation of Escherichia coli O157:H7 induced intestinal inflammation. The results showed that microencapsulation could significantly increase the colon content of Bifidobacterium, relieve intestinal inflammation symptoms in mice with bacterial enteritis, and repair the intestinal microbiota disorder caused by inflammation. The probiotic double-layered multinucleated microcapsules prepared in this study can improve the survival rate of probiotics and promote proliferation, adhesion, and colonization of probiotics.

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Section: Preparation Of Probiotic Microcapsules 2111 Preparation Of I...mentioning

confidence: 99%

Construction of Probiotic Double-Layered Multinucleated Microcapsules Based on Sulfhydryl-Modified Carboxymethyl Cellulose Sodium for Increased Intestinal Adhesion of Probiotics and Therapy for Intestinal Inflammation Induced by Escherichia coli O157:H7

Zhang

Liu

Fang

et al. 2023

ACS Appl. Mater. Interfaces

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“…These natural products possess characteristics of low toxicity and high biological affinity. Among them, herbal polysaccharides (HPS) stand out due to their exceptional mechanical strength, enabling them to impart anti-inflammatory, analgesic, hemostatic, and anti-fibrotic properties (Yang et al, 2022b;Zhang et al, 2022b).…”

Section: Herbal Polysaccharidementioning

confidence: 99%

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Tang,

Li,

You

et al. 2023

Front. Bioeng. Biotechnol.

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Wound healing is a dynamic and complex restorative process, and traditional dressings reduce their therapeutic effectiveness due to the accumulation of drugs in the cuticle. As a novel drug delivery system, microneedles (MNs) can overcome the defect and deliver drugs to the deeper layers of the skin. As the core of the microneedle system, loaded drugs exert a significant influence on the therapeutic efficacy of MNs. Metallic elements and herbal compounds have been widely used in wound treatment for their ability to accelerate the healing process. Metallic elements primarily serve as antimicrobial agents and facilitate the enhancement of cell proliferation. Whereas various herbal compounds act on different targets in the inflammatory, proliferative, and remodeling phases of wound healing. The interaction between the two drugs forms nanoparticles (NPs) and metal-organic frameworks (MOFs), reducing the toxicity of the metallic elements and increasing the therapeutic effect. This article summarizes recent trends in the development of MNs made of metallic elements and herbal compounds for wound healing, describes their advantages in wound treatment, and provides a reference for the development of future MNs.

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Peptide OM-LV20 promotes arteriogenesis induced by femoral artery ligature via the miR-29b-3p/VEGFA axis

Zhang,

Kang,

Wang

et al. 2024

Atherosclerosis

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Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats

Cited by 4 publications

References 61 publications

Construction of Probiotic Double-Layered Multinucleated Microcapsules Based on Sulfhydryl-Modified Carboxymethyl Cellulose Sodium for Increased Intestinal Adhesion of Probiotics and Therapy for Intestinal Inflammation Induced by Escherichia coli O157:H7

Construction of Probiotic Double-Layered Multinucleated Microcapsules Based on Sulfhydryl-Modified Carboxymethyl Cellulose Sodium for Increased Intestinal Adhesion of Probiotics and Therapy for Intestinal Inflammation Induced by Escherichia coli O157:H7

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Peptide OM-LV20 promotes arteriogenesis induced by femoral artery ligature via the miR-29b-3p/VEGFA axis

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