Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Tang, Xiao; Li, Li; You, Gehang; Li, Xinyi; Kang, Jian

doi:10.3389/fbioe.2023.1283771

Cited by 3 publications

(8 citation statements)

References 246 publications

(271 reference statements)

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“…The results of our study indicated that TENS therapy has substantial impact on reducing the occurrence of wound infections, expediting wound healing, alleviating pain and enhancing overall patient satisfaction after the Caesarean section. [18][19][20][21] The significant decrease in wound infection rates observed in the TENS group aligns with previous research indicating the moderating impact of TENS on the immune response. According to Machado et al (2012), 21,22 TENS has the potential to improve blood circulation in the area and consequently enhance the transportation of immune cells to the wound site, thereby reducing the chances of infection.…”

Section: Discussionsupporting

confidence: 83%

“…TENS group exhibited significantly superior wound healing rates. According to Tang et al (2023), 21 the observed phenomenon can be ascribed to the augmentation of cellular proliferation and angiogenesis. According to Rabbani (2024), 22 the application of electrical stimulation by TENS has the potential to elevate the local temperature, hence enhancing the activity of enzymes that are essential for the process of tissue repair.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

“…The significant decrease in wound infection rates observed in the TENS group aligns with previous research indicating the moderating impact of TENS on the immune response. According to Machado et al (2012), 21 , 22 TENS has the potential to improve blood circulation in the area and consequently enhance the transportation of immune cells to the wound site, thereby reducing the chances of infection. Furthermore, decrease in antibiotic utilization among individuals in the TENS cohort may have significant implications for the responsible use of antimicrobials.…”

Section: Discussionmentioning

confidence: 99%

“… 19 Moreover, the observed prolonged pain alleviation in our individuals may be attributed to the elevation of endogenous endorphin levels resulting from electrical stimulation. 20 , 21 , 22 , 23 , 24…”

Section: Discussionmentioning

confidence: 99%

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The role of TENS therapy in reducing the incidence of post‐Caesarean section wound infection

Qin,

Liu,

Liu

2024

International Wound Journal

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The occurrence of wound infection following a Caesarean section procedure poses a substantial clinical obstacle. Transcutaneous Electrical Nerve Stimulation (TENS) has been identified as a promising supplementary treatment option for improving the healing process and decreasing the incidence of infections. This study assessed the efficacy of TENS therapy in the postoperative care of patients who have had Caesarean section. We randomly assigned a total of 108 women who had Caesarean sections to either a TENS group (n = 54) or control (n = 54). The TENS therapy was provided twice daily for a duration of 30 min for the period of 14 days following the surgery. The main measure of interest in this study was the occurrence of wound infection during 30‐day period. Additionally, secondary measures included the rate of wound healing, levels of pain experienced and level of patient satisfaction. In comparison to the control (22.2%, p < 0.05), the TENS group had notably reduced occurrence of wound infection, with the rate of 7.4%. TENS group had superior wound healing results, as measured by REEDA scale, at 7 days (2.1 ± 0.8 vs. 2.5 ± 1.0, p < 0.04), 14 days (1.2 ± 0.5 vs. 1.9 ± 0.7, p < 0.05) and 30 days (0.3 ± 0.5 vs. 0.7 ± 0.6, p < 0.05). Furthermore, TENS group had reduced pain levels on the Visual Analog Scale (VAS) at all evaluation intervals (p < 0.05). TENS group exhibited significantly higher levels of patient satisfaction, as evidenced by 64.8% of participants rating high satisfaction, in contrast to 40.7% in the control group (p < 0.05). The incidence of adverse effects was found to be minor, as indicated by a skin irritation rate of 3.7% and reported discomfort rate of 1.9% at the electrode location. TENS therapy effectively decreased the occurrence of post‐Caesarean wound infections, expedited the healing process and enhanced pain control. This treatment was well‐received by patients and had little negative consequences. The aforementioned results provided evidence in favour of incorporating TENS into post‐Caesarean care regimens, which may have significant consequences for improving patient outcomes and maximizing healthcare resources.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The role of TENS therapy in reducing the incidence of post‐Caesarean section wound infection

Qin,

Liu,

Liu

2024

International Wound Journal

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Antimicrobial Activity of Water-Soluble Silver Complexes Bearing C-Scorpionate Ligands

Mahmoud,

Sousa,

Guedes da Silva

et al. 2024

Antibiotics

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The novel hydrosoluble silver coordination polymer [Ag(NO3)(μ-1κN;2κN′,N″-TPMOH)]n (1) (TPMOH = tris(1H-pyrazol-1-yl)ethanol) was obtained and characterized. While single crystal X-ray diffraction analysis of compound 1 disclosed an infinite 1D helical chain structure in the solid state, NMR analysis in polar solvents confirmed the mononuclear nature of compound 1 in solution. Compound 1 and the analogue [Ag(μ-1κN;2κN′,N″-TPMS)]n (2) (TPMS = tris(1H-pyrazol-1-yl)methane sulfonate) were evaluated with regard to their antimicrobial activities towards the Gram-negative Escherichia coli, Pseudomonas aeruginosa, and Burkholderia contaminans, the Gram-positive Staphylococcus aureus, and the fungal species Candida albicans and Candida glabrata. Compound 1 exhibited minimal inhibitory concentration (MIC) values ranging from 2 to 7.7 µg/mL towards the tested Gram-negative bacteria, 18 µg/mL towards the Gram-positive S. aureus, and 15 and 31 µg/mL towards C. albicans and C. glabrata, respectively. Compound 2 was less effective towards the tested bacteria, with MIC values ranging from 15 to 19.6 µg/mL towards the Gram-negative bacteria and 51 µg/mL towards S. aureus; however, it was more effective against C. albicans and C. glabrata, with MIC values of about 6 µg/mL towards these fungal species. The toxicity of compounds 1 and 2 was assessed by evaluating the survival of the Caenorhabditis elegans model organism to concentrations of up to 100 µg/mL. The value of 50% lethality (LD50) could only be estimated as 73.2 µg/mL for compound 1 at 72 h, otherwise LD50 was >100 µg/mL for both compounds 1 and 2. These results indicate compounds 1 and 2 as novel silver complexes with interesting antimicrobial properties towards bacterial and fungal pathogens.

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Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications

Cao,

Sun,

Qin

et al. 2024

Pharmaceutics

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Wound healing progresses through three distinct stages: inflammation, proliferation, and remodeling. Immune regulation is a central component throughout, crucial for orchestrating inflammatory responses, facilitating tissue repair, and restraining scar tissue formation. Elements such as mitochondria, reactive oxygen species (ROS), macrophages, autophagy, ferroptosis, and cytokines collaboratively shape immune regulation in this healing process. Skin wound dressings, recognized for their ability to augment biomaterials’ immunomodulatory characteristics via antimicrobial, antioxidative, pro- or anti-inflammatory, and tissue-regenerative capacities, have garnered heightened attention. Notwithstanding, a lack of comprehensive research addressing how these dressings attain immunomodulatory properties and the mechanisms thereof persists. Hence, this paper pioneers a systematic review of biomaterials, emphasizing immune regulation and their underlying immunological mechanisms. It begins by highlighting the importance of immune regulation in wound healing and the peculiarities and obstacles faced in skin injury recovery. This segment explores the impact of wound metabolism, infections, systemic illnesses, and local immobilization on the immune response during healing. Subsequently, the review examines a spectrum of biomaterials utilized in skin wound therapy, including hydrogels, aerogels, electrospun nanofiber membranes, collagen scaffolds, microneedles, sponges, and 3D-printed constructs. It elaborates on the immunomodulatory approaches employed by these materials, focusing on mitochondrial and ROS modulation, autophagic processes, ferroptosis, macrophage modulation, and the influence of cytokines on wound healing. Acknowledging the challenge of antibiotic resistance, the paper also summarizes promising plant-based alternatives for biomaterial integration, including curcumin. In its concluding sections, the review charts recent advancements and prospects in biomaterials that accelerate skin wound healing via immune modulation. This includes exploring mitochondrial transplantation materials, biomaterial morphology optimization, metal ion incorporation, electrostimulation-enabled immune response control, and the benefits of composite materials in immune-regulatory wound dressings. The ultimate objective is to establish a theoretical foundation and guide future investigations in the realm of skin wound healing and related materials science disciplines.

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Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Cited by 3 publications

References 246 publications

The role of TENS therapy in reducing the incidence of post‐Caesarean section wound infection

The role of TENS therapy in reducing the incidence of post‐Caesarean section wound infection

Antimicrobial Activity of Water-Soluble Silver Complexes Bearing C-Scorpionate Ligands

Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications

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