Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune reaction that occurs during dysregulated immune restoration in immunocompromised patients in late-stage human immunodeficiency virus (HIV) infection who have commenced antiretroviral treatments (ART). Virtually any opportunistic pathogen can provoke this type of immune restoration disorder. In this review, we focus on recent developments in the identification of risk factors for Cryptococcal IRIS and on advancements in our understanding of C-IRIS immunopathogenesis. We overview new findings in blood and cerebrospinal fluid which can potentially be useful in the prediction and diagnosis of cryptococcal meningitis IRIS (CM-IRIS). We assess current therapeutic regimens and novel treatment approaches to combat CM-IRIS. We discuss the utility of biomarkers for clinical monitoring and adjusting treatment modalities in acquired immunodeficiency syndrome (AIDS) patients co-infected with Cryptococcus who have initiated ART.
RESUMOEmbora não seja obrigatória, a residência médica faz parte do processo de ensino e da formação dos médicos e é considerada padrão ouro na modalidade de ensino de pós-graduação lato sensu. Entretanto, o número de vagas para residência médica não acompanhou a expansão dos cursos de graduação em Medicina, gerando uma intensa disputa por uma vaga nos cursos de residência, o que fez proliferar os cursos preparatórios para os exames de residência (CP). A evasão do interno de Medicina de suas atividades acadêmicas para se dedicar às atividades dos cursinhos preparatórios para os exames de residência médica preocupa os docentes. Este estudo tem por objetivo traçar um perfil no internato da Faculdade de Medicina de São José do Rio Preto (Famerp) sobre a adesão dos internos aos CP. Os resultados apontam que a imensa maioria dos 297 alunos pesquisados pretende fazer residência médica e que apenas 27 alunos (84,4%) dos 32 que consideravam o curso de preparação necessário, mas não dispunham de recursos financeiros para frequentá-los. Os entrevistados afirmaram que a maior qualidade dos cursos preparatórios reside na didática das aulas e que a maior desvantagem destes é a dissociação entre conteúdo teórico e prático, também vivida no internato. Concluímos que a percepção dos internos e acadêmicos de Medicina é bem definida quanto aos cursinhos preparatórios para residência médica. Apesar de aderirem à prática destes cursinhos, sabem que há uma dicotomia entre a teoria e a prática oferecida no internato, o que prejudica a formação profissional. A grande maioria dos acadêmicos pesquisados pretende fazer a residência médica após o internato, dando continuidade aos estudos e ao aprendizado. Por outro lado, a atual conjuntura do mercado de trabalho na área da medicina, marcada por uma concorrência acirrada, e as exigências constantes de atualização e aperfeiçoamento levam os acadêmicos a verem na residência o único caminho natural após o internato e ainda uma alternativa para sanar as possíveis deficiências do internato. Mudanças na graduação sugeridas pelos pesquisados, como melhor didática em aulas da graduação e a abordagem de conteúdo teórico durante o internato, refletem a deficiência da graduação e do internato, a qual pode ser sanada com uma postura mais assertiva de professores e preceptores. ABSTRACT Although not compulsory, medical residency is part through the physicians' teaching and training process. It is considered the gold standard in the teaching modality of Lato Sensu Graduate Programs.However, the number of residency positions available has not kept pace with the expansion of medical undergraduate courses, resulting in high levels of competition for medical residency vacancies, and a proliferation of preparatory courses (PC) offering supervised postgraduate training. The evasion of clerkship students from their academic activities to take prep courses in order to apply for a residency position is a cause for concern among teachers. This study outlines a profile in the São José do Rio Preto (Famerp) School o...
Introduction and Objective: Human anatomy is an essential component of the undergraduate nursing curriculum for learning the specific disciplines which deal with clinical practice. Anatomical knowledge provides assurance for the practice of clinical assessment and invasive procedures of legal competence of nurses. The aim of the study was to analyze the correlation of the content taught in the discipline Human Anatomy with the clinical practice of undergraduate nursing students in the discipline Semiology and Semiotics in Nursing and The Care Process, as well as their assurance to start it.Methods: Quantitative descriptive study with the application of an online questionnaire to 66 undergraduate nursing students at a public education institution in the interior of São Paulo. Data analysis by number of occurrences and Chi-square test.Results: There was partial agreement about the interdisciplinarity between human anatomy and disciplines of clinical nursing practice. The students agreed to be partially assured about the procedures to start the semiological practice of different devices and to perform nursing procedures. The predominance of the superficial approach to content related to the clinical practice of the disciplines Semiology and Semiotics in Nursing and The Care Process was predominant.Conclusions: The teaching of human anatomy, along the lines offered, maintains an unsatisfactory correlation with clinical practice due to the students’ experience, interfering with learning, acting in clinical teaching and professional training.
Resumo A maioria dos atuais graduandos nasceu entre 1982 e 2000. Trata-se dos chamados “millennials”, e essa geração espera que a educação integre a tecnologia. Com isso, este estudo, transversal e descritivo-exploratório, propõe-se a conhecer a relação de estudantes de medicina do ciclo básico com as tecnologias interativas da web – as quais podem melhorar o ensino –, visando fornecer informações para implementá-las com mais eficiência no meio acadêmico. Os resultados evidenciam que os alunos utilizam ferramentas da internet, mas com pouca diversidade, sendo as plataformas mais usadas o Google Docs, Facebook, YouTube e Dropbox. O artigo conclui que é necessário promover o contato com a tecnologia na educação médica a fim de preparar os alunos para enfrentar futuros desafios profissionais.
Resumo As escolas médicas devem incorporar o ensino do profissionalismo ao currículo para garantir que as próximas gerações de médicos estejam preparadas para uma prática profissional compassiva, humana e ética, adequada aos interesses da sociedade em um mundo com demandas cada vez maiores e em constante mudança. A maior contribuição deste estudo é evidenciar o fraco desempenho dos estagiários nos aspectos jurídicos e de apoio nas situações abordadas. Os dados falam a favor de uma política de capacitação institucionalizada como o primeiro passo para que o setor da saúde priorize a competência em atenção à saúde das vítimas de violência relacionada a gênero e a sexualidade não heterossexual.
Introduction: Almost 20 years since the beginning of affirmative action implementation, there is still much discussion about the real effectiveness of these measures, especially regarding academic performance, comparing “quota holders” to “non-quota holders”, with doubts arising about whether the former can keep up with the latter. Objective: To establish a profile and compare the academic performance and other aspects related to the academic life of “quota holder” students (Inclusion Program with Merit in Public Higher Education in São Paulo - PIMESP) with the other students in their respective classes selected via broad competition (BC). Method: Retrospective cohort of 1st to 3rd-year medical students, divided in BC or PIMESP. The following were assessed: arithmetic mean of the final grades of the curricular subjects; final approval status (FAS) in the subjects; frequency; books borrowed from the library (BBLi) and participation in monitoring/academic center. Continuous variables were compared by Student’s t-test or Mann-Whitney test and categorical by chi-square or Fisher’s exact test. Values p < 0.05 were considered significant. Results: Of the 237 students included in the sample, all had completed the 1st year (2015, 2016 and 2017 entrants), 158 students (2015 and 2016 entrants) the 1st and 2nd years, and 78 (32.9%) had completed the 3rd year (2015 entrants) at the time of the survey. In the analysis of all those who had completed the 1st year, where 16% were PIMESP, there was a difference in mean final grades and FAS, higher for BC students and no difference for attendance, BBLi, participation in monitoring and academic center. In the analysis of those who had completed the 2nd year, where 15.8% were PIMESP, there was no difference between any of the studied variables. The analysis of those who had completed the 3rd year, where 15.4% were PIMESP, once again showed difference between the averages of final grades and FAS, higher for BC students, but with a less marked difference, and there were no significant differences for the other variables. Conclusion: We observed a fluctuation of academic performance among PIMESP students, towards inferior outcomes, when compared to BC students, throughout the first three years of medical school, but not for other variables. No increase in the dropout rate was observed, contrary to what is found in the literature.
Introduction: Almost 20 years since the beginning of affirmative action implementation, there is still much discussion about the real effectiveness of these measures, especially regarding academic performance, comparing “quota holders” to “non-quota holders”, with doubts arising about whether the former can keep up with the latter. Objective: To establish a profile and compare the academic performance and other aspects related to the academic life of “quota holder” students (Inclusion Program with Merit in Public Higher Education in São Paulo - PIMESP) with the other students in their respective classes selected via broad competition (BC). Method: Retrospective cohort of 1st to 3rd-year medical students, divided in BC or PIMESP. The following were assessed: arithmetic mean of the final grades of the curricular subjects; final approval status (FAS) in the subjects; frequency; books borrowed from the library (BBLi) and participation in monitoring/academic center. Continuous variables were compared by Student’s t-test or Mann-Whitney test and categorical by chi-square or Fisher’s exact test. Values p < 0.05 were considered significant. Results: Of the 237 students included in the sample, all had completed the 1st year (2015, 2016 and 2017 entrants), 158 students (2015 and 2016 entrants) the 1st and 2nd years, and 78 (32.9%) had completed the 3rd year (2015 entrants) at the time of the survey. In the analysis of all those who had completed the 1st year, where 16% were PIMESP, there was a difference in mean final grades and FAS, higher for BC students and no difference for attendance, BBLi, participation in monitoring and academic center. In the analysis of those who had completed the 2nd year, where 15.8% were PIMESP, there was no difference between any of the studied variables. The analysis of those who had completed the 3rd year, where 15.4% were PIMESP, once again showed difference between the averages of final grades and FAS, higher for BC students, but with a less marked difference, and there were no significant differences for the other variables. Conclusion: We observed a fluctuation of academic performance among PIMESP students, towards inferior outcomes, when compared to BC students, throughout the first three years of medical school, but not for other variables. No increase in the dropout rate was observed, contrary to what is found in the literature.
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