Our findings suggest that HPV16 may play a role in the etiology of a subgroup of HNSCC in Puerto Ricans. Overall survival times of the HPV16-positive patients were not significantly different from those of HPV16-negative patients. Increasing our understanding of the role of HPV16 in the etiology of HNSCC might facilitate the development of new treatment modalities for this subgroup of HNSCC.

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Chylous fistula is a well-recognized complication of neck dissection, occurring in 1% to 2% of cases. 1 Cardiopulmonary complications, on the other hand, are rare. Bilateral chylothorax is an extremely rare occurrence following neck dissection. Severe respiratory, metabolic, and immunologic derangements can occur secondary to chylothorax. We report a case of bilateral chylothorax after neck dissection and cervical thoracic duct ligation.