High frequency of HPV16‐associated head and neck squamous cell carcinoma in the Puerto Rican population

Báez, Adriana; Almodóvar, José I.; Cantor, Alan; Celestin, Frederic; Cruz-Cruz, Luis; Fonseca, Sharon; Trinidad‐Pinedo, Juan; Vega, William A.

doi:10.1002/hed.20046

Cited by 36 publications

(37 citation statements)

References 34 publications

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“…82 The presence of HPV DNA in a significant fraction of OSCC raised the question of whether HPV tumor status affects the outcome of oral cancer. To date, the findings have been inconsistent, with some studies reporting no survival differences 84,87,94 and others clearly stating a reduction in death risk among patients with HPVpositive tumors when compared with those with HPVnegative tumors. 82,83,88,[90][91][92] A large study conducted by Gillison et al 82 has shown that patients with HPVpositive tumors had a 60% reduction in risk of death from cancer and significantly improved disease-specific survival when compared patients with HPV-negative tumors.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…There is escalating evidence of a causal association between HPV and OSCC, [82][83][84][85][86][87][88][89][90][91][92][93] with several studies showing that HPV is associated with increased risk of oral cancer, independently of exposure to tobacco and alcohol. 84,86,88,89 This association is valid for high-risk HPV, which comprises subtypes 16, 18, 33, and 35. HPV-16 may be responsible for more than 80% of HPV-positive OSCC.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…85,86 p53 remains the most commonly mutated gene in many common human cancers, but in a high proportion of cases lacking mutations its function is compromised by other mechanisms. 83,84,92 Regarding HPV, this may occur via interaction of p53 with protein E6 encoded by the oncogenic HPV types, mainly HPV-16 and HPV-18, which results in increased ubiquitin-dependent proteolysis of p53. 82,83,[92][93][94] The expression of wild-type p53 in HPV-positive tumors contrasts with the higher frequency of p53 mutation in HPV-negative cases, and this fact seems to be associated with better prognosis in patients with HPV-positive OSSC.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…82,83,94 Recently published data on the prevalence of HPV infection in OSCC points to rates between 15% and 30%, but this might be an underestimation; it may ascend to more than 50%. 84,86,87,89,91 The disparity found in the published data has been associated with variations in collection of samples, the efficiency of the detection procedure, and geographic parameters. It is not well established how HPV infects the upper airway and oral cavity, but epidemiologic evidence suggests sexual transmission, 82,93 because the prevalence of infection increases after the onset of sexual activity, although the presence of HPV in OSCC has not yet been robustly linked to sexual practices such as oral sex.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

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Oral squamous cell carcinoma: Review of prognostic and predictive factors

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

View full text Add to dashboard Cite

“…Separately, the HPV 16 detected in larynx was 85.7% and 55.6% in hypopharynx. When aggregated, the hypopharynx and larynx showed 56% (29 cases) of all HPV16 DNA detected in the study (Báez et al, 2004).…”

Section: Larynx Cancersmentioning

confidence: 76%

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis

Ragin

Taioli

2007

Intl Journal of Cancer

650

513

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Human papillomavirus (HPV) has been associated with head and neck squamous cell carcinomas (HNSCC), especially of the oropharynx, with highest distribution in the tonsils. HPV infection has been associated with improved outcome, although not all the studies show consistent results. The reason for this is not clear. We reviewed all published articles and conducted a meta-analysis on the overall relationship between HPV infection and overall survival (OS) and disease-free survival (DFS) in HNSCC. Patients with HPV-positive HNSCC had a lower risk of dying (meta HR: 0.85, 95% CI: 0.7-1.0), and a lower risk of recurrence (meta HR: 0.62, 95%CI: 0.5-0.8) than HPV-negative HNSCC patients. Sitespecific analyses show that patients with HPV-positive oropharyngeal tumours had a 28% reduced risk of death (meta HR: 0.72, 95%CI: 0.5-1.0) in comparison to patients with HPV-negative oropharyngeal tumours. Similar observations were made for DFS (meta HR: 0.51, 95% CI: 0.4-0.7). There was no difference in OS between HPV-positive and negative non-oropharyngeal patients. The observed improved OS and DFS for HPV-positive HNSCC patients is specific to the oropharynx; these tumours may have a distinct etiology from those tumours in non-oropharyngeal sites. ' 2007 Wiley-Liss, Inc.Key words: HPV; overall survival; disease-free survival; head and neck cancerThe majority of head and neck tumours are differentiated squamous cell carcinomas (SCC), which occur in the oral cavity, oropharynx, hypopharynx and larynx. Approximately 45,660 new cases and 11,210 deaths from cancers of the oral cavity, pharynx and larynx are expected in the United States in 2007.1 The 5-year relative age-adjusted survival rate for these head and neck sites was 58% between 1973 and 2002 (58% for males and 60% for females), 2 and have remained unchanged for more than 3 decades. This poor survival rate is primarily due to the late stage of diagnosis, and to a high frequency of recurrence and second primary tumours. [3][4][5][6][7] Human papillomavirus (HPV) is associated with the development of most anogenital carcinomas, including cervical cancer and, has more recently been suggested to be a risk factor for a subset of head and neck squamous cell carcinoma (HNSCC).8 Most HPV-associated HNSCC tend to occur in the oropharynx, with highest distribution in the tonsils. HPV16 is the predominant genotype detected in head and neck tumours, with different prevalence between head and neck subsites. A recent review of the prognostic significance of HPV in survival of head and neck cancer patients has shown that the majority of studies have reported better survival in patients with HPV-positive head and neck tumours when compared to patients with HPV-negative tumours.9 However, the same review also reported that in some studies, HPV infection resulted in a worse prognosis or had no influence on prognosis.We have reviewed all published articles that have addresses the impact of HPV infection on the outcome of patients with HNSCC, and have also conducted a meta-analysis of the pub...

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High frequency of HPV16‐associated head and neck squamous cell carcinoma in the Puerto Rican population

Cited by 36 publications

References 34 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis

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