Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano, João; Regateiro, Frederico S.; Januário, Gustavo; Ferreira, Artur

doi:10.1016/j.tripleo.2005.07.038

Cited by 518 publications

(461 citation statements)

References 103 publications

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“…This may be attributed to a relatively high prevalence of use of smokeless tobacco in our population [2]. The prognosis of patients with these cancers depends upon a wide range of factors that may be grouped into patient-, tumour-and treatment-related [4]. Amongst the various patient-related factors, the socio-economic factors and health-seeking behavior of the patients may have a direct bearing on the stage of disease at presentation, and thus, on the overall prognosis [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 97%

Treatment Delay in Oral and Oropharyngeal Cancer in Our Population: The Role of Socio-Economic Factors and Health-Seeking Behaviour

Agarwal

Sethi

Sareen

et al. 2011

Indian J Otolaryngol Head Neck Surg

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The objective is to assess the role of socioeconomic factors and health-seeking behavior in treatment delay in oral and oropharyngeal cancer in our population. This article adapts-design: prospective study and setting: tertiary care centre. We studied 153 patients with oral and oropharyngeal squamous cell carcinoma who were managed in the department of otolaryngology and head and neck surgery between January 2006 and December 2007. There were 127 male patients (83%) and 26 females (17%) with ages ranging from 22 years to 70 years. Fifty-nine patients (39%) presented to us with early stage disease (i.e. stage I and II), whereas, 94 patients (61%) presented with late stage disease (i.e. stage III and IV). Of the 59 patients presenting with early stage disease, 20 were illiterate and 39 literate with 28 patients (47%) belonging to low socio-economic status and 32 patients (54%) having an access to primary health centre (PHC). Of the 94 patients presenting with late stage disease, 53 were illiterate and 41 literate with 58 patients (62%) belonging to low socio-economic status and 38 patients (40%) having an access to primary health centre. Literacy, socio-economic status, access to primary health centre and health-seeking behavior of our population has a significant association with the stage of presentation of patients with oral and oropharyngeal cancer.

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Section: Introductionmentioning

confidence: 97%

Treatment Delay in Oral and Oropharyngeal Cancer in Our Population: The Role of Socio-Economic Factors and Health-Seeking Behaviour

Agarwal

Sethi

Sareen

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…Functional inactivation of p53 causes defects in DNA repair and apoptosis, with a subsequent increase in genetic instability that can lead to the accumulation of mutations (Abusail et al, 2013;Liu L et al, 2014). The high expression of p53 due to high rate of mutations has been linked with a unfavorable prognosis in OSCC patients (Lippman and Hong, 2001;Schliephake, 2003;Massano et al, 2006;Montoro et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Abbasi¹,

Khiavi²,

Amir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

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“…One of the factors governing the poor prognosis of oral SCC is frequent metastasis of cancer cells to regional lymph nodes or distant organs (Massano et al, 2006;Rusthoven et al, 2010). Combinatorial chemotherapy coupled with nanomedicine have opened appealing window to the current therapeutic approaches that always failed due to tumor cell resistance and unwanted side effects of drug on normal cells, However aggressive advances made when nano-based drug delivery systems paired with combination chemotherapeutic agents (Rossi et al, 2010;Liboiron and Mayer 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Squamous cell carcinoma (SSC) of the tongue has historically been shown to be associated with a poor prognosis , much more an aggressive biological and clinical behavior and a high metastatic potential (Jones et al, 1992; BrandweinGensler et al, 2005;Kademani et al, 2005;Bell et al, 2007;Montoro et al, 2008). Patients with premalignant lesions and early stage cancers have a high rate of survival, but the vast majority of Stages III and IV cases are fatal (Zwetyenga et al, 2003;Massano et al, 2006;Montoro et al, 2008).The prognosis of SCC depends on a series of factors such as proliferative activity of the tumor, …”

mentioning

confidence: 99%

Oral and IV Dosages of Doxorubicin-Methotrexate loaded-Nanoparticles Inhibit Progression of Oral Cancer by Down-Regulation of Matrix Methaloproteinase 2 Expression in Vivo

Abbasi¹,

Jahanban‐Esfahlan²,

Amir³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (24), 10705-10711 IntroductionSquamous cell carcinomas encompass approximately 95% of all oral malignancies. Oral cancer holds the sixth position in cancer incidence ranking worldwide (Albano et al., 2013;Baykara et al., 2013). Squamous cell carcinoma (SSC) of the tongue has historically been shown to be associated with a poor prognosis , much more an aggressive biological and clinical behavior and a high metastatic potential (Jones et al., 1992; BrandweinGensler et al., 2005;Kademani et al., 2005;Bell et al., 2007;Montoro et al., 2008). Patients with premalignant lesions and early stage cancers have a high rate of survival, but the vast majority of Stages III and IV cases are fatal (Zwetyenga et al., 2003;Massano et al., 2006;Montoro et al., 2008).The prognosis of SCC depends on a series of factors such as proliferative activity of the tumor,

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Oral squamous cell carcinoma: Review of prognostic and predictive factors

Cited by 518 publications

References 103 publications

Treatment Delay in Oral and Oropharyngeal Cancer in Our Population: The Role of Socio-Economic Factors and Health-Seeking Behaviour

Treatment Delay in Oral and Oropharyngeal Cancer in Our Population: The Role of Socio-Economic Factors and Health-Seeking Behaviour

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Oral and IV Dosages of Doxorubicin-Methotrexate loaded-Nanoparticles Inhibit Progression of Oral Cancer by Down-Regulation of Matrix Methaloproteinase 2 Expression in Vivo

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