Cenp‐F gene amplification and overexpression in head and neck squamous cell carcinomas

Guardia, Carola de la; Casiano, Carlos A.; Trinidad‐Pinedo, Juan; Báez, Adriana

doi:10.1002/1097-0347(200102)23:2<104::aid-hed1005>3.3.co;2-s

Cited by 11 publications

(15 citation statements)

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“…Similar to Waitzberg et al,68 no correlation was found between c‐myc amplification and clinical data in our series. In contrast to our data, Gapany et al69 observed a negative correlation between c‐myc and tumor size or nodal involvement whereas de la Guardia et al66 and Rodrigo et al64 observed a positive significant correlation between c‐myc and T classification.…”

Section: Discussioncontrasting

confidence: 99%

“…Although genetic alterations in the c‐myc oncogene play an important role in the induction and progression of human cancer,58–60 limited and controversial information is available on the role of c‐myc in HNSCC. The present report revealed c‐myc amplification in tumors of 15% of the patients, which is consistent with the described frequencies of amplification and expression of 6% to 25% in the literature 61–67. We only observed a relationship of c‐myc amplification with tumor grade.…”

Section: Discussionsupporting

confidence: 93%

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Prognostic value of plasminogen activator inhibitor‐1 in head and neck squamous cell carcinoma

et al. 2006

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Background. Tumor cell biological factors, such as urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1), cathepsin D, and c-myc play a role in tumor invasion, metastasis, and proliferation. In this study, the prognostic importance of these factors in patients with primary head and neck squamous cell carcinoma (HNSCC) was evaluated and correlated with clinicopathologic variables.Methods. In 46 paired primary tumors and normal tissues, levels of uPA, PAI-1, cathepsin D, and c-myc amplification were determined. The clinical follow-up was over 10 years. Relationships between cell biological factors and patient and tumor characteristics were studied by the Mann-Whitney test. The Cox proportional hazard model was used for univariate and multivariate analysis.Results. In this study, only a high level of PAI-1 was associated with a significantly shorter disease-free survival (p < .01). PAI-1 levels were higher in tumors with perineural invasion (p < .01). Both PAI-1 and uPA levels were higher in patients who smoked (p < .01 and p ¼ .02). In univariate analysis, smoking (p ¼ .04), excessive alcohol intake (p ¼ .02), perineural invasion (p ¼ .001), and vaso-invasion (p ¼ .009) were associated with a shorter disease-free survival. The only factor related to overall survival was perineural invasion (p ¼ .045). The combination of a high PAI-1 level and perineural invasion appeared to be a significant predictor of a shorter disease-free interval (p ¼ .01).Conclusion. PAI-1 may present a novel prognostic factor for patients with HNSCC. Perineural invasion and PAI-1 level combined seemed to be prognostic for disease-free survival. Keywords: head and neck cancer; uPA; PAI-1; perineural; invasion Head and neck squamous cell carcinoma (HNSCC) represents the sixth most common cancer worldwide. 1 Annually there are approximately 500,000 new cases of HNSCC worldwide, 2500 cases in The Netherlands alone. 2,3 Despite advances in diagnosis and therapy, long-term survival of HNSCC patients has only moderately improved during the past 20 years. This is due to the relatively high local recurrence rate, metastatic spread, and secondary primary cancers. About 10% to 20% of the patients develop regional recurrences, 4,5 25% to 30% distant metastases, 6 and 5% to 36% develop a second primary tumor in the head and neck region. 4 Tumor status and especially cervical lymph node status are regarded as the most important prognostic factors for overall survival. It has been reported that the 5-year overall survival is reduced by approximately 50% in patients with a node Correspondence to: E. M. J. J. Berns

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Prognostic value of plasminogen activator inhibitor‐1 in head and neck squamous cell carcinoma

et al. 2006

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“…It was demonstrated previously that the deregulation of centromere proteins is implicated in the development and progression of various cancers. Studies have demonstrated that the CENP‐F gene is up‐regulated in head and neck squamous cell carcinoma by genomic amplification26 and that CENP‐F expression is associated with a poor prognosis in patients with primary breast cancer 13. Another centromere protein, CENP‐A, is up‐regulated in colorectal cancer cells 12.…”

Section: Discussionmentioning

confidence: 99%

Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival

Liao¹,

Wang²,

Xu³

et al. 2009

Cancer

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“…Centromere proteins, including CENP‐F, have been identified through a previous study of the autoantibodies to the centromere from patients with the CREST syndrome and of antibodies prepared against purified chromosome scaffolds 19 . The CENP‐F gene was mapped at 1q32–41 20,21 . Previous findings point to the hypothesis that autoimmunity to this protein could be related to events in the host involving increased or abnormal cell proliferation 22 .…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma

Esguerra¹,

Jia²,

Kaneko

et al. 2004

Pathology International

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Centromere protein F (CENP-F) expression (localization and characteristics) in relation to tumor clinicopathological parameters was immunohistochemically examined and evaluated in 47 archival biopsy specimens of buccal and gingival squamous cell carcinomas (SCC). Centromere protein F expression was detected in 79% of the samples. An increase in the labeling index (LI) with WHO grading was obtained (P < 0.05). Correlations were obtained between the CENP-F LI and tumor size (P < 0.05). Immunoelectron microscopy showed CENP-F nuclear staining as punctate or fine dots. The present study shows that CENP-F expression and detection of a more specific cell subpopulation presents a theoretical advantage for the analysis of the precise cell cycle of G2 to M cells, compared to Ki-67.

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Cenp‐F gene amplification and overexpression in head and neck squamous cell carcinomas

Cited by 11 publications

References 0 publications

Prognostic value of plasminogen activator inhibitor‐1 in head and neck squamous cell carcinoma

Prognostic value of plasminogen activator inhibitor‐1 in head and neck squamous cell carcinoma

Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival

Immunohistochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma

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