All previously published data on gene frequencies of the ADA and SOD systems are compiled in this paper.

We evaluated the files of 80 women who were treated for vulvar carcinoma. In 13 women radiotherapy was used as primary treatment, in 45 cases postoperatively and in 22 women because of local recurrence. Patients older than 60 years had a significantly worse 5-year survival rate (39%) than younger women (57%) (p = 0.02). The 5-year survival rate for patients with negative nodes was 72% versus 46% for the N1- and 47% for the N2-status, respectively (p = 0.027). The 5-year actuarial survival rate for patients with tumor manifestation in the clitoris was 77.9% versus 26.1% for patients with tumors in the labia majora (p = 0.0044). There was no difference in survival in patients who had been treated with radical vulvectomy and bilateral groin dissection plus local radiotherapy when compared with patients who had been irradiated (whole pelvis) after tumor resection alone. The 5-year survival rates and the median survival time were identical in both groups (61%/62 months).

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Phenotypes of glyoxalase I (GLO I) were determined in 1,000 unrelated persons from Portugal giving the gene frequencies GLO 1 = 0.463 and GLO2= 0.537. Zusammenfassung. Phfinotypen der Glyoxalase wurden bestimmt bei 1000 nicht miteinander verwandten Personen aus Portugal. Genfrequenzen ffir G L O I = 0,463 und GLO2= 0,537 wurden errechnet.

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1251 blood samples of non-related human beings coming from the area of Lübeck have been examined. Frequencies of the esterase D allel were EsD1 = 0.9001 and EsD2 = 0.0999.

Phenotypes and gene frequencies of the erythrocyte enzyme adenosine deaminase were determined in samples from Schleswig-Holstein, Portugal, Brazil, and South Africa (Bantu-Xhosa and White). In the Portugal population the phenotypes ADA 5-1 and ADA 5-2 were found.Zusammenfassung. In einer populationsgenetischen Studie wurden die Ph/~notypen und Genfrequenzen ftir das Erythrozytenenzym Adenosindesaminase in Bev61kerungsgruppen aus Schleswig-Holstein, Portugal, Brasilien und Stidafrika (Bantu-Xhosa und Weige) ermittelt. In der portugiesischen Population fanden sich die Phfinotypen ADA 5-1 und ADA 5-2.