Survey of the Distribution of Adenosine Deaminase and Superoxide Dismutase Markers in Different Populations

Weissmann, John S.; Vollmer, Marcell; Pribilla, O.

doi:10.1159/000153321

Cited by 18 publications

(27 citation statements)

References 36 publications

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“…Therefore, we chose a random control group consisting of consecutive newborns from the same population as the study group, which seems as nonbiased as possible. The frequency of ADA*2 allele in the control group (7.3%, 95% confidence interval: 5.1–10.2%) was similar to the values reported 30 years ago in two distinct Polish groups (8.9% in Lower Silesia and 6.0% in Krakow) [6], indicating the lack of significant population drift. It was also similar to other European Caucasian populations (Germany: 4.5–7.3%, Denmark: 5.6–6.7%, Hungary: 6.2–10.1%, Italy: 6.0–9.1%, Portugal: 5.5%) [6].…”

Section: Discussionsupporting

confidence: 81%

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ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease

Safranow

Rzeuski²,

Bińczak-Kuleta³

et al. 2007

Cardiology

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Background/Aims: The common G22A polymorphism in the adenosine deaminase (ADA) gene leads to substitution Asp8Asn. The lower activity of the enzyme encoded by A22 (ADA*2) allele may increase tissue concentrations of adenosine, a potent cardioprotective agent. In a case-control study, we investigated the association between ADA polymorphism and coronary artery disease (CAD). Methods: A hundred and seventy-one CAD patients from the north-western part of Poland and 200 consecutive newborns from the same population were genotyped by PCR-RFLP. Results: Twenty-five ADA*1/*2 heterozygotes (12.5%) and 2 ADA*2/*2 homozygotes (1%) were found in the control group, while only 10 *1/*2 heterozygotes (5.9%) and no *2/*2 homozygotes were found in the CAD group. Frequencies of ADA*2 carriers (5.9% vs. 13.5%, p = 0.015) and ADA*2 allele (2.9% vs. 7.3%, p = 0.0083) were lower in CAD patients than in controls. Among CAD patients, a significantly lower proportion of *2 allele carriers was treated with diuretics and ACE inhibitors when compared to *1/*1 wild-type homozygotes. Conclusion: ADA*2 allele may decrease genetic susceptibility to CAD. ADA should be added to the list of candidate genes modifying the risk of cardiovascular diseases.

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Section: Discussionsupporting

confidence: 81%

“…The enzyme encoded by the A22 allele (described also as ADA*2 or ADA2) has about 35% less catalytic activity than enzyme encoded by G22 allele (ADA*1, ADA1), and individuals carrying one copy of ADA*2 allele display 15–20% lower activity compared to ADA*1 homozygotes [5]. ADA*2 allele is present in approximately 12% of Caucasians [6]. …”

Section: Introductionmentioning

confidence: 99%

ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease

Safranow

Rzeuski²,

Bińczak-Kuleta³

et al. 2007

Cardiology

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“…The electrophoretic 2-1 1-1 1-1 1-1 5-1 1-1 1-1 1-1 1-1 5-1 1-1 2-1 1-1 1-1 Phenotype mobility was the same as that described for the first time by Detter et al [1970] and subsequently by others [Weissmann et al, 1982] and called ADA 5-1.…”

Section: Resultsmentioning

confidence: 57%

“…The fre quency of the A DA *2 allele ranges from 0.0018 to 0.138 [Weissmann et al, 1982], It has been demonstrated [Battistuzzi et Rogers and Hopkinson [1981] calculated that the enzymatic activity of the rare variants ADA IW and ADA 3 were 67 and 28%, respectively, of the enzyme activity of the common variant ADA I. Giblett et al [1972] described an asso ciation between the absence of erythro cytic ADA activity and an autosomal recessive form of severe combined immu nodeficiency disease (SC1D).…”

Section: Introductionmentioning

confidence: 99%

Enzyme Activity and Distribution of Adenosine Deaminase Types in a Population of Central Italy

Lucarini¹,

Borgiani²

1989

Hum Hered

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Blood samples from 718 unrelated individuals born in municipalities of the ‘Alto Maceratese’ region in central Italy were examined for adenosine deaminase (ADA). The allele frequencies for ADA*1 and ADA*2 were 92.48 and 7.45%, respectively. One case of the rare ADA 5–1 phenotype was observed. The observed phenotype distribution agreed well with the one expected assuming a Hardy-Weinberg equilibrium. Enzyme activity was measured in red blood cells from individuals with different phenotypes. The relationships between the enzyme activity of the phenotypes was found to be ADA 1 > ADA 2–1 > ADA 2 > ADA 5–1.

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“…[28], with the exception of northern Sweden which has well-known strong finnish affin ities [29]. AK1, ADA.…”

Section: Gene Frequenciesmentioning

confidence: 99%

A Population Genetic Study in Finland: Comparison of the Finnish- and Swedish-Speaking Populations

Virtaranta-Knowles

Sistonen²,

Nevanlinna³

1991

Hum Hered

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In Finland there is a substantial but geographically limited Swedish-speaking minority (in 1980 6.3% of the total population) which originates mainly from Swedish immigrants during the years 1100–1300 AD. The admixture of this population with the neighbouring Finns was studied using more than 20 blood marker loci. The reference populations, Swedes and Finns, in spite of being part of the genetically rather uniform European populations, differ from each other genetically. These quantitative and also qualitative differences in gene frequencies are mostly due to the Finnish population possessing a number of genetic markers absent or rare in the rest of Europe. The results based on a sample of 620 individuals from the Swedish-speaking population in Finland showed a rather high degree of Finnish admixture, which was estimated to about 60%. This admixture most probably occurred at an early stage since it has reached such a high and geographically homogeneous degree.

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Survey of the Distribution of Adenosine Deaminase and Superoxide Dismutase Markers in Different Populations

Abstract: All previously published data on gene frequencies of the ADA and SOD systems are compiled in this paper.

Cited by 18 publications

References 36 publications

ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease

ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease

Enzyme Activity and Distribution of Adenosine Deaminase Types in a Population of Central Italy

A Population Genetic Study in Finland: Comparison of the Finnish- and Swedish-Speaking Populations

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