No abstract

Background: Oral and dental problem is common among many Nigerian populace. The human oral cavity is one of the most dynamic habitats for numerous bacterial species where they undergo intense interspecies competition to form multispecies biofilm structure. Aim: The present study was designed to assess the oral bacterial profile and antibiogram of Adult Patients receiving dental care at Babcock University Teaching Hospital (BUTH), Ilishan-Remo Ogun State. Methods: A total of 200 oral swab samples were collected from 200 consenting participants (100 males and 100 females). The oral swab samples were cultured on Blood agar, MacConkey agar and Mannitol salt agar and incubated at 37 o C. Gram staining, motility test and routine biochemical tests were done for the identification and characterization of the bacterial isolates. Antibiotic susceptibility testing was carried out using the disc diffusion method. Data obtained were analysed using SPSS Statistics software package (version 18.0). Results: The bacterial species isolated include: Streptococcus viridans, Staphylococcus epidermidis, Enterobacter spp, Streptococcus pyogenes, Enterococcus feacalis, Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. Out of the 288 bacterial isolates obtained, 139 (65.5%) of the oral bacteria isolates were non-pathogenic in nature, while 69 (34.5%) were pathogenic. The pathogenic organism with the highest percentage occurrence was Enterobacter spp (37.7%), followed by Streptococcus pyogenes (24.6%), Enterococcus feacalis (19.7%), Klebsiella pneumoniae (9.8%), Staphylococcus aureus (4.9%) and the least being Escherichia coli (3.3%). Most of the Gram positive bacteria were sensitive to Augmentin, Sulbactomas, Cefroxime, Ciprofloxacin, Levofloxacin, Erythromycin and Azithromycin; while most of the Gram negative bacteria were sensitive to Augumentin, Cefotaxime, Nalidixic acid, Nitrofurantoin and Gentamycin. Conclusion: Pathogenic bacteria capable of causing oral and dental problems exist in the oral cavity of Patients receiving dental care at BUTH with varied antibiotic susceptibility patterns. The outcome of this study underscored the importance of routine oral/dental checks, adequate oral/dental care and treatment of oral infection with appropriate antibiotics.

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SUMMARY The prevalence of penicillinase producing Neisseria gonorrhoeae (PPNG) strains has been steadily rising in Nigeria since 1979, and now about 80% ofthe strains of gonococci isolated in Ibadan are found to produce penicillinase. Spectinomycin has consequently become widely used in treating these infections. To ascertain the emergence of spectinomycin resistance, this study was undertaken to assess the in vivo susceptibilities of gonococcal strains to spectinomycin and other common antibiotics. Five hundred and twenty seven isolates were tested, of which 452 (85.5%) were PPNG strains. None of the strains were found to be resistant to 100 ,ug spectinomycin discs in vitro, whereas all 370 patients treated with the antibiotic were bacteriologically cured. Plasmid analysis shows that both "Asian" and "African" PPNG types are circulating in Nigeria. For the moment spectinomycin remains highly effective in treating gonococcal infections in west Africa.

Background: Some spices have been reported to play contributory role in enhancing male reproductive function. Aims: To determine the effect of Piper guineense consumption on some libido indices and behavioral pattern of male Wistar rats at different concentrations. Study Design: This is a Cross-sectional nonclinical study in animal model.