Libido Enhancement Potential of Piper guineense in Male Wistar Rats

Ochei, John Okeleke; Enitan, Samson Seyi; Effedua, Hyacinth; Omodiale, P.; Giwa, Oluwatosin

doi:10.9734/ajob/2017/36542

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…In this study, there was an observed loss of appetite, sluggishness, passive behavior, prolonged response to external stimuli, and a color change in feces, which was agreed upon [24] . Those findings might have led to the retarded growth and weight loss recorded in this research.…”

Section: Discussionsupporting

confidence: 78%

Neuromodulatory roles of PIPER GUINEENSE and honey against Lead-Induced neurotoxicity in social interactive behaviors and motor activities in rat models

Obinna¹,

Shallom²,

Ogugua³

et al. 2022

AIMSN

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<abstract><sec> <title>Background</title> <italic>Piper guineense</italic> and honey contain antioxidative, anti-inflammatory, and antimicrobial properties that can help restore neuronal and other cell damage. To investigate the neuromodulatory roles of <italic>p. guineense</italic> and honey against lead toxicity on the hippocampus and cerebellum, impairing social behaviors and motor activities. </sec><sec> <title>Methodology</title> Thirty Wistar rats were separated into six groups of five rats each, marked with dye. Group A served as control; B was untreated lead; C was a medium dose of the extract (50 mg/kg) and honey (1000 mg/kg); D was a high dose of the extract (80 mg/kg) and honey (1500 mg/kg); E received extract (80 mg/kg), and F received honey (1500 mg/kg). All groups received 110 mg/kg of lead orally, except the control. Social interaction, antidepressant effects, and motor activities were studied using a sociability chamber (SC), Forced Swim Test (FST), and String methods. A blood sample was used to evaluate glutathione peroxidase (GPx) and glutathione oxide transaminase (GOT), while the lipid level was estimated using cerebellar homogenate. Neuronal damage, vacuolation, necrosis, cell degeneration, and alterations in both hippocampus and cerebellum marked untreated group, with decreased GPx and GOT activities followed by impaired motor activities, social behavior, memory, and motivation. Using SCT, group B spent significantly lesser time (47.60 ± 47.60) with stranger 1 compared to A (138.20 ± 34.05), while group C spent considerably more time with stranger 1 (86.80 ± 30.32) than group B at P ≥ 0.05. The treatment increased the enzyme level and restored histoarchitecture (<xref ref-type="fig" rid="neurosci-09-04-026-g001">Figures 1</xref>–<xref ref-type="fig" rid="neurosci-09-04-026-g012">12</xref>), improving motor activities, social behavior, memory, motivation, and social affiliation (<xref ref-type="table" rid="neurosci-09-04-026-t03">Tables 3</xref>, <xref ref-type="table" rid="neurosci-09-04-026-t04">4</xref>, <xref ref-type="table" rid="neurosci-09-04-026-t02">2</xref>, and <xref ref-type="table" rid="neurosci-09-04-026-t06">6</xref>). The extract and honey may be helpful as neuromodulators in lead toxicity in a dose-dependent manner. </sec></abstract>

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Section: Discussionsupporting

confidence: 78%

Neuromodulatory roles of PIPER GUINEENSE and honey against Lead-Induced neurotoxicity in social interactive behaviors and motor activities in rat models

Obinna¹,

Shallom²,

Ogugua³

et al. 2022

AIMSN

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“…Aphrodisiac potentials: Using parameters such as penile erection index, copulatory behaviour and orientation activities towards themselves (genital grooming) and female rats (anogenital sniffing, mounting), aqueous extracts of P. guineense modified the sexual behaviour of male rats by increasing sexual arousal (Kamtchouing et al 2002). Memudu et al, (2015) and Ochei et al, (2017) also investigated the aphrodisiac potentials of this plant and obtained results similar to that of Kamtchouing et al, (2002).…”

Section: Phytochemical Constituent Of Piper Guineensesupporting

confidence: 62%

Ethnomedicinal Uses and Therapeutic Activities of Piper Guineense: A Review

Alagbe¹,

Alagbe²,

Adekunle³

et al. 2021

jasem

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The use of medicinal plants in most developing countries as therapeutic agents for the maintenance of good health is a widespread practice. One of such plant products is Piper guineense, which is a West African spice used in many folklore medicines and has a number of verified pharmacological activities. Proximate analysis reveals that the plant contains crude protein, fat, carbohydrate, vitamins and minerals while preliminary phytochemical screening and gas chromatography-mass spectrophotoscopy of the methanol leaf and seed extract of Piper guineense revealed the presence of several constituents such as alkaloids, glycosides, tannins, flavonoids, terpenes; sesquiterpenoids and monoterpenoids, saponins and secondary metabolites such as Aromadendrene, 1,6,10- Dodecatriene,7,11-dimethyl-3-methylene and piperine, piperidine amongst other secondary metabolites. Studies have revealed that Piper guineense possess several pharmacological and therapeutic properties such as anti-oxidant, anti-microbial, aphrodisiac, anti-parasitic, antiinflammatory, anti-convulsant, molluscicidal, oestrogenic and oxytocic properties. This paper provides a review on the morphology, physicochemical and phytochemical constituents, ethnomedicinal and scientifically proven therapeutic activities of Piper guineense.

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Randomized, Triple-Blinded, Placebo-Controlled Trial of SA3X (Spilanthes acmella) for the Management of Erectile Dysfunction

Patnaik¹,

Mishra²,

Pradhan³

2022

Cureus

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Introduction Spilanthes acmella has been used as an aphrodisiac in India and other countries. However, studies concerning humans have been limited. This randomized controlled trial was carried out to evaluate the effect of SA3X capsules containing 500 mg of S. acmella on sexual function domain scores in sexually active men with symptoms of erectile dysfunction (ED) using the Men’s Sexual Health Questionnaire (MSHQ). Materials and methods This triple-blind, placebo-controlled, parallel-group was conducted at two centres in Hyderabad and Secunderabad from May to December 2021. Patients were randomized 1:1 to SA3X therapy or placebo for one month along with an observational cohort. The change of MSHQ score and its subdomains from baseline to month 1 (primary endpoint) and one-month post-treatment (secondary outcome) was assessed using a mixed model repeated measures analysis. Additional secondary outcomes measured were the change in the International Index of Erectile Function (IIEF) and duration of penile erection. Safety was evaluated. Results The intention-to-treat population included 448 patients (152 - SA3X therapy; 146 - placebo; 150 - observational cohort). A significant increase was observed with SA3X therapy versus placebo on the total MSHQ score (17.24 vs 4.72; SE: 2.11, 1.98; P<0.001) along with the sub-domains at the end of one month of therapy. At one-month post-treatment, the increase in MSHQ score with SA3X therapy was significant (18.48 vs 3.78; SE 2.81, 1.39; P<0.001). The IIEF scores and duration of penile erection also increased significantly in the SA3X therapy group. Dysgeusia (3.94%) was the most common drug-related adverse effect. No serious adverse effects were noted. Conclusion SA3X was concluded to be safe and effective as a potential treatment for ED.

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Libido Enhancement Potential of Piper guineense in Male Wistar Rats

Cited by 3 publications

References 13 publications

Neuromodulatory roles of <i>PIPER GUINEENSE</i> and honey against Lead-Induced neurotoxicity in social interactive behaviors and motor activities in rat models

Neuromodulatory roles of <i>PIPER GUINEENSE</i> and honey against Lead-Induced neurotoxicity in social interactive behaviors and motor activities in rat models

Ethnomedicinal Uses and Therapeutic Activities of Piper Guineense: A Review

Randomized, Triple-Blinded, Placebo-Controlled Trial of SA3X (Spilanthes acmella) for the Management of Erectile Dysfunction

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