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Protective effect of remote ischemic per-conditioning in the Protective effect of remote ischemic per-conditioning in the Protective effect of remote ischemic per-conditioning in the Protective effect of remote ischemic per-conditioning in the Protective effect of remote ischemic per-conditioning in the ischemia and reperfusion-induce renal injury in rats ischemia and reperfusion-induce renal injury in rats ischemia and reperfusion-induce renal injury in rats ischemia and reperfusion-induce renal injury in rats ischemia and reperfusion-induce renal injury in rats Efeito protetor do per-condicionamento isquêmico remoto nas lesões da Efeito protetor do per-condicionamento isquêmico remoto nas lesões da Efeito protetor do per-condicionamento isquêmico remoto nas lesões da Efeito protetor do per-condicionamento isquêmico remoto nas lesões da Efeito protetor do per-condicionamento isquêmico remoto nas lesões da síndrome de isquemia e reperfusão renal em ratos síndrome de isquemia e reperfusão renal em ratos síndrome de isquemia e reperfusão renal em ratos síndrome de isquemia e reperfusão renal em ratos síndrome de isquemia e reperfusão renal em ratos Fifteen rats (Rattus norvegicus) were randomized into three groups (n = 5): Group Normality (GN), ControlIschemia and Reperfusion (GIR) and Group remote ischemic per-conditioning (GPER). With the exception of the GN group, all others underwent renal ischemia for 30 minutes. In group GPER we performed the ischemic remote per-conditioning, consisting of three cycles of ischemia and reperfusion applied every five minutes during the ischemic period, to the left hindlimb of the rats by means of a tourniquet. To quantify the lesions we measured serum levels of creatinine and urea, as well as analyzed renal histopathology. Results Results ResultsResults Results: The GPER group presented with better levels of urea (83.74 ± 14.58%) and creatinine (0.72 ± 26.14%) when compared to GIR group, approaching the GN group. Histopathologically, the lower levels of medullary congestion and hydropic degeneration were found in group GPER. Conclusion Conclusion Conclusion Conclusion Conclusion: The remote ischemic per-conditioning had a significant protective effect on renal ischemia and reperfusion.

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