Combined remote ischemic perconditioning and local postconditioning on liver ischemia–reperfusion injury

Costa, Felipe Lobato da Silva; Yamaki, Vítor Nagai; Gonçalves, Thiago Barbosa; Coelho, João Vitor Baia; Percário, Sandro; Brito, Marcus Vinicius Henriques

doi:10.1016/j.jss.2014.05.046

Cited by 25 publications

(30 citation statements)

References 23 publications

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“…The association had slightly worse outcome that could be of statistical significance in a larger series. We suggest that the complementary postconditioning cycles might lead to additional tissue damage, in opposition to the expected additional protection, or at least act in the same pathway, saturating it 18 . So, we can also conclude that PER is the best tissue conditioning for kidney ischemia and reperfusion syndrome.…”

Section: ■ Discussionmentioning

confidence: 90%

“…Perconditioning is the newest technique described to mitigate IR injury in many tissues 15,18,20 . Our study is the first evaluate of the potential protective effect of PER alone or combined with POS on kidney IR-induced injury, that only be test before in myocardium 15,20 , brain 17,26 , and liver 18 .…”

Section: ■ Discussionmentioning

confidence: 99%

“…Renal ischemia was induced by applying a microsurgical clip on the renal artery. Hindlimb ischemia was achieved using an elastic rubber band tied around the thigh of the left leg, through a non-invasive method that was successfully used in previous studies 18,22 .…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…This technique led to a pronounced protection to the myocardium against the deleterious effects of the ischemia and reperfusion. Since then, this technique has been demonstrated to protect brain, liver, myocardium and kidney from the IR syndrome in various animal models and in clinical settings [16][17][18][19][20][21] .…”

Section: ■ Introductionmentioning

confidence: 99%

“…PER might be even more practical than POS, because it is performed in a distant tissue and is a non-invasive procedure, thus does not require direct access to the artery and could be easily applied during endovascular revascularization 18,22 . Mechanisms underlying the remote ischemic conditioning are barely understood.…”

Section: ■ Introductionmentioning

confidence: 99%

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Perconditioning combined with postconditioning on kidney ischemia and reperfusion

et al. 2017

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Purpose: To evaluate if combination of perconditioning and postconditioning provides improved renal protection compared to perconditioning alone in a model of renal reperfusion injury. Methods: Thirty rats were assigned into 6 groups: normality; sham; ischemia and reperfusion; postconditioning; perconditioning; perconditioning + postconditioning. Animals were subjected to right nephrectomy and left renal ischemia for 30 minutes. Postconditioning consisted of 3 cycles of 5 min renal perfusion followed by 5 min of renal ischemia after major ischemic period. Perconditioning consisted of 3 cycles of 5 min hindlimb ischemia followed by 5 min of hindlimb perfusion contemporaneously to renal major ischemic period. After 24 hours, kidney was harvested and blood collected to measure urea and creatinine. Results: Perconditioning obtained better values for creatinine and urea level than only postconditioning (p<0.01); performing both techniques contemporaneously had no increased results (p>0.05). Regarding tissue structure, perconditioning was the only technique to protect the glomerulus and tubules (p<0.05), while postconditioning protected only the glomerulus (p<0.05). Combination of both techniques shows no effect on glomerulus or tubules (p>0.05). Conclusions: Perconditioning had promising results on ischemia and reperfusion induced kidney injury, enhanced kidney function and protected glomerulus and tubules. There was no additive protection when postconditioning and perconditioning were combined.

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Section: ■ Discussionmentioning

confidence: 90%

Section: ■ Discussionmentioning

confidence: 99%

Section: Surgical Proceduresmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Perconditioning combined with postconditioning on kidney ischemia and reperfusion

et al. 2017

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Remote Ischemic Preconditioning has a Cardioprotective Effect in Children in the Early Postoperative Phase: A Meta-Analysis of Randomized Controlled Trials

et al. 2018

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In this updated meta-analysis, we assessed the cardioprotective effect of remote ischemic preconditioning (RIPC) in pediatric patients undergoing congenital heart surgery. A total of 9 randomized controlled trials (RCTs) involving 793 pediatric patients under 18 years old were identified. RIPC obviously reduced the release of troponin I at 6 h after surgery [standard mean difference (SMD) -0.59, 95% confidence interval (CI) -1.14 to -0.04; p = 0.03], mitigated the inotropic scores within 4-6 h (SMD -0.43, 95% CI -0.72 to -0.14; p = 0.004) and within 12 h (SMD -0.26, 95% CI -0.50 to -0.02; p = 0.03) and shortened the ventilator support time (SMD -0.28, 95% CI -0.49 to -0.07; p = 0.01) as well as the duration of intensive care unit (ICU) stay (SMD -0.21, 95% CI -0.35 to -0.06; p = 0.004). Our meta-analysis determined that RIPC had cardioprotective effects in the early postoperative phase. Additional RCTs focused on the cardiac benefits from RIPC in pediatric patients are warranted.

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The effect of pre- and post-remote ischemic conditioning reduces the injury associated with intestinal ischemia/reperfusion

et al. 2020

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Combined remote ischemic perconditioning and local postconditioning on liver ischemia–reperfusion injury

Cited by 25 publications

References 23 publications

Perconditioning combined with postconditioning on kidney ischemia and reperfusion

Perconditioning combined with postconditioning on kidney ischemia and reperfusion

Remote Ischemic Preconditioning has a Cardioprotective Effect in Children in the Early Postoperative Phase: A Meta-Analysis of Randomized Controlled Trials

The effect of pre- and post-remote ischemic conditioning reduces the injury associated with intestinal ischemia/reperfusion

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