Background: The rapid worldwide spread of the Omicron variant of SARS-CoV-2 has unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved drug, is still unknown in patients infected with the Omicron variant.Objective: Evaluated the antiviral efficacy and safety of molnupiravir in patients infected with SARS-CoV-2 Omicron variant, with symptom duration within 5 days.Methods: We conducted a randomized, controlled trial involving patients with mild or moderate COVID-19. Patients were randomized to orally receive molnupiravir (800 mg) plus basic treatment or only basic treatment for 5 days (BID). The antiviral efficacy of the drug was evaluated using reverse transcriptase polymerase chain reaction.Results: Results showed that the time of viral RNA clearance (primary endpoint) was significantly decreased in the molnupiravir group (median, 9 days) compared to the control group (median, 10 days) (Log-Rank p = 0.0092). Of patients receiving molnupiravir, 18.42% achieved viral RNA clearance on day 5 of treatment, compared to the control group (0%) (p = 0.0092). On day 7, 40.79%, and 6.45% of patients in the molnupiravir and control groups, respectively, achieved viral RNA clearance (p = 0.0004). In addition, molnupiravir has a good safety profile, and no serious adverse events were reported.Conclusion: Molnupiravir significantly accelerated the SARS-CoV-2 Omicron RNA clearance in patients with COVID-19.Clinical Trial Registration: [chictr.org.cn], identifier [ChiCTR2200056817].
A catalyst-free
chemoselective trimerization reaction of readily
available isocyanides is described. This domino reaction provides
facile access to a wide range of 2-(indol-2-yl)-quinolines and 2-(indol-2-yl)-pyridines
in moderate to excellent yields. A “head to head” heterodimerization
of two isocyanides is proposed as the key step of this reaction.
-Traditional real estate business models are not able to attract young generation customers since they are used to acquire required information from digital apps and devices. This paper aims to develop a framework for application of advanced visualization technology in residential property marketing to offer a detailed 3D information model to customers through the real estate websites. The paper presents the result of a survey examining the experience of customers who were used one of the five selected real estate on-line platforms in Australia. The survey targets a sample of 120 participants, who are selected at the University of New South Wales covering different genders and nationalities. Based on the result of the survey, the framework is verified and shows how 3D scanners can be useful for on-line property management. The results would be useful for property managers to communicate with customers by providing visualized information, and customers can easily examine whether the property meets their requirement without any physical inspection. The application of visualization technologies to residential property marketing will provide customers with more reliable and credible property information by 3D modeling and pictures, which is beneficial to property owners, customers and other stakeholders as well as real estate agents.
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