Objective:The objective was to investigate the antiurolithiatic and antioxidant activity of ethanolic extract of Hordeum vulgare seeds (EHV) on ethylene glycol-induced urolithiasis in Wistar albino rats.Materials and Methods:Urolithiasis was produced in Wistar albino rats by adding 0.75% v/v ethylene glycol (EG) to drinking water for 28 days. The ethanolic extract of Hordeum vulgare seeds (EHV) was assessed for its curative and preventive action in urolithiasis. In preventive treatment, the EHV given from 1st day to 28th day, while in the curative regimen, the EHV was given from 15th day to 28th day. Various renal functional and injury markers such as urine volume, calcium, phosphate, uric acid, magnesium, urea, and oxalate were evaluated using urine, serum, and kidney homogenate. Antioxidant parameters such as lipid peroxidation, superoxide dismutase, and catalase were also determined.Results:The EHV treatment (both preventive and curative) increased the urine output significantly compared to the control. The EHV treatment significantly reduced the urinary excretion of the calcium, phosphate, uric acid, magnesium, urea, and oxalate and increased the excretion of citrate compared to EG control. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by curative and preventive treatment with EHV. It was also observed that the treatment with EHV produced significant decrease in lipid peroxidation, and increased levels of superoxide dismutase and catalase.Conclusion:These results suggest the usefulness of ethanolic extract of Hordeum vulgare seeds as an antiurolithiatic and antioxidant agent.
Objective of the study was to evaluate protective effect the Ethanolic extract of seeds of Hordeum vulgare was tested in an animal model of nephrotoxicity. Nephrotoxicity was induced by the addition of Gentamicin (80 mg/kg; i.p) to the normal diet of Wistar albino rats for a period of 10 days. Group I served as a normal control. Group II served as nephrotoxicity control. Group III, IV and V were treated with ethanolic extract of Hordeum vulgare (EHV) at 100, 250 and 500 mg/kg respectively. The effects of EHV on various biochemical parameters were studied in Nephrotoxicity rats. Gentamycin induced nephrotoxicity in rats, there were significant elevated kidney weight, body weight loss and blood vessel congestion and scattered mononuclear inflammatory cell within the interstitial in gentamycin induced rats. In vivo antioxidant parameters including protein, malondialdehyde, superoxide dismutase, reduced glutathione and catalase (CAT) were also determined. EHV significantly maintained the renal parameters like serum urea, BUN, creatinine. The extract also induced a significant decrease in MDA which increased in nephrotoxicity control rats. The extract also significantly increased reduced glutathione, superoxide (100,250) and CAT in nephrotoxicity rats which were markedly decreased in gentamicin induced nephrotoxicity in rats. This study demonstrates the protective activity of Hordeum vulgare seeds and rationalizes their medicinal use for the treatment of nephrotoxicity.
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