Protective Effect of Ethanolic Extract of Hordeum Vulgare Seed on Gentamicin Induced Nephrotoxicity

Abstract

Objective of the study was to evaluate protective effect the Ethanolic extract of seeds of Hordeum vulgare was tested in an animal model of nephrotoxicity. Nephrotoxicity was induced by the addition of Gentamicin (80 mg/kg; i.p) to the normal diet of Wistar albino rats for a period of 10 days. Group I served as a normal control. Group II served as nephrotoxicity control. Group III, IV and V were treated with ethanolic extract of Hordeum vulgare (EHV) at 100, 250 and 500 mg/kg respectively. The effects of EHV on various biochemical parameters were studied in Nephrotoxicity rats. Gentamycin induced nephrotoxicity in rats, there were significant elevated kidney weight, body weight loss and blood vessel congestion and scattered mononuclear inflammatory cell within the interstitial in gentamycin induced rats. In vivo antioxidant parameters including protein, malondialdehyde, superoxide dismutase, reduced glutathione and catalase (CAT) were also determined. EHV significantly maintained the renal parameters like serum urea, BUN, creatinine. The extract also induced a significant decrease in MDA which increased in nephrotoxicity control rats. The extract also significantly increased reduced glutathione, superoxide (100,250) and CAT in nephrotoxicity rats which were markedly decreased in gentamicin induced nephrotoxicity in rats. This study demonstrates the protective activity of Hordeum vulgare seeds and rationalizes their medicinal use for the treatment of nephrotoxicity.

An Investigation of the Protective Influence of Dates Fruit Against Nephrotoxicity in Wistar Albino Rats Induced by Gentamicin

“…Diisooctyl adipate has toxicological properties in biological fluids and tissues [44], 1,2-Benzenedicarboxylic acid has shown promising results as a chemopreventive/chemotherapeutic agent against osteosarcoma [45], diisooctyl ester, which has antioxidant and anti-inflammatory properties [46], Z,E-3,13-octadecadien-1-ol, which has antioxidant properties [47].When eicosane exhibited higher antibacterial, antifungal, and antioxidant activity [48].The heptadecane, 2,6,10,15-tetramethyl-, beneficial as a promising source of antimicrobial and antioxidant therapeutic agents [49], oxirane, hexadecyl-, ntimicrobial compounds [50]and benzenepropanoic acid phytochemicals with antimicrobial and anticancer properties [51], Hence, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, antimicrobial activities ( [52],octadecyl ester, the promising inhibition efficiency of these compounds against the pathogenic bacteria [53]. The antimicrobial and antioxidant compounds [54], 13-tetradecen-1-ol acetate, and 2-pentadecanone, antioxidants [55], 6,10,14-trimethyl-2-Octadecyl-propane-1,3-diol the findings suggest that fungal endophytes from the medicinal plant could be a potential candidate for bioactive compounds with pharmaceutical properties [56] Many studies have used this plant as a preventive agent against GM nephrotoxicity and have obtained good results due to antioxidant content in plants [57,58]. Previous results support our findings, which indicate that date fruit has high contents of antioxidants and phytochemicals.…”

Physiological and behavioral study on depressed rats model treated with Hordeum vulgare extract referenced to SSRI class

“…Group 1 kept as control, feeding on basal diet, group 2 received reserpine i.p (0.5 mg/ kg) for 20 days day other day 22 , group 3 received reserpine plus Fluxotine (10 mg/kg p.o) 23 for 20 days, group 4 received reserpine plus H. vulgare seed 70% ethanolic extract (1,000 mg/kg p.o) for 20 days. Group 5 received reserpine plus Fluxotine and H. vulgare for 20 days 24 . Rats were grouped and housed in a conventional clean facility, according to the guidelines of the Institutional Animal Ethics Committee of NODCAR.…”