The implantation of multifunctional carbon aerogel (CA)-coated β-TCP scaffolds for synchronously improving the photothermal ablation and enhanced bone regeneration of osteosarcoma.

In clinical treatment, the bone regeneration of critical‐size defects is desiderated to be solved, and the regeneration of large bone segment defects depends on early vascularization. Therefore, overcoming insufficient vascularization in artificial bone grafts may be a promising strategy for critical‐size bone regeneration. Herein, a novel dual‐drug programmed releasing electrospinning fibrous mat (EFM) with a deferoxamine (DFO)‐loaded shell layer and a dexamethasone (DEX)‐loaded core layer is fabricated using coaxial electrospinning technology, considering the temporal sequence of vascularization and bone repair. DFO acts as an angiogenesis promoter and DEX is used as an osteogenesis inducer. The results demonstrate that the early and rapid release of DFO promotes angiogenesis in human umbilical vascular endothelial cells and the sustained release of DEX enhances the osteogenic differentiation of rat bone mesenchymal stem cells. DFO and DEX exert synergetic effects on osteogenic differentiation via the Wnt/β‐catenin signaling pathway, and the dual‐drug programmed releasing EFM acquired perfect vascularized bone regeneration ability in a rat calvarial defect model. Overall, the study suggests a low‐cost strategy to enhance vascularized bone regeneration by adjusting the behavior of angiogenesis and osteogenesis in time dimension.

Controlled Drug Release In article 2200571, Min Zhu, Xudong Wang, Kaili Lin and co‐workers fabricate a novel dual‐drug loading coaxially electrospinning fibrous mat with programmed release behavior. The early and rapid release of angiogenesis‐promoting drug deferoxamine promotes the angiogenesis of vascular endothelial cells and the sustained release of osteogenesis‐inducing drug dexamethasone enhances osteogenesis of bone mesenchymal stem cells, and synergistically boosts vascularized bone regeneration.

The postoperative tumor recurrence and repairing skin defects in clinical melanoma therapy remain challenging. Recent years have seen the development of visible-to-near-infrared (NIR) light for melanoma therapy or tissue regeneration. For solving the integrated issue of melanoma treatment and skin wounds repair, a gentle and efficient strategy is essential to utilize the multifunction of light. Here, we presented a new lightmediation concept and reported a light-responsive intelligent hydrogel system by introducing two-dimensional (2D) borocarbonitride (BCN) nanosheets into the methacrylated hyaluronic acid (HA) matrix (HA@BCN). The hydrogel was skillfully fabricated under the activation of blue light and exhibited excellent biocompatibility, mechanical robustness, and biodegradability, and then, a gentle and powerful multifunction for cutaneous melanoma therapy and wound healing under NIR light irradiation was performed. Based on this result, multifunctional hydrogels could be triggered by NIR light (0.35 W/cm 2 ) for killing tumor cells, at least an 80% mortality rate in 10 min. Subsequently, the HA@BCN hydrogel could release more boron moieties as the growth promoter under moderate NIR light irradiation, which largely accelerated the wound healing. Therefore, our discovery presented a light-mediated and 2D nanomaterial-functionalized versatile hydrogel system for cutaneous melanoma photothermal therapy.

No abstract

No abstract