Novel bone tumor cell targeting nanosystem for chemo-photothermal therapy of malignant bone tumors

Wang, Yitong; Cui, Jinjie; Chen, Jiajie; Wan, Jianyu; Liang, Yakun; Qi, Ming; Wang, Xudong; Zhang, Lei; Lin, Kaili

doi:10.1016/j.cej.2022.136905

Cited by 9 publications

(3 citation statements)

References 53 publications

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“…Combining the synergistic effects that MNP can bear, a range of strategies, including enhanced imaging, targeted drug delivery, and HT therapy, can be applied in bone tumor therapy. [148][149][150][151][152][153][154][155][156] The diagnostic and therapeutic (theragnostic) attributes of MNP are of the utmost importance in bone tumor therapy. Aiming for more personalized and precise interventions, MNP integrating diagnostic and therapeutic features can lead to improved outcomes.…”

Section: Magnetic Hyperthermia Treatment and Tissue Repairmentioning

confidence: 99%

“…[51,53,56,61] Developing hydroxyapatite (HA) particles with a magnetic core or doping HA or β-tricalcium phosphate (β-TCP) with transition metal ions has been the most explored approaches to attain CaP-based powders with magnetic properties. [52,57,60,63,139,155,202,[205][206][207][208][209][210][211] By combining the biocompatible and bioactive properties of hydroxyapatite (HA) with the magnetic properties of pure magnetite, it is possible to obtain Fe 3 O 4 /HA core-shell NP of increased therapeutic value and with a greater application potential as a suitable platform for the construction of multifunctional and bimodal magnetic-theranostic carriers, for clinical oncology and novel MRI contrast agents. [57,58,174,177,179,212,213] However, it should be kept in mind that the formed shell may have a thickness greater than the core size, which may result in the decrease of the saturation magnetization of the magnetic material.…”

Section: Calcium Phosphate-based Particles With Intrinsic Magnetic Pr...mentioning

confidence: 99%

“…Taking benefit of the magnetic guidance, the researchers successfully accumulated and targeted the osteosarcoma region, resulting in high tumor inhibition efficiency of their proposed theranostic agent, highlighting the synergistic effects of magnetic guidance and chemophotothermal therapy capacities. In the work conducted by Yitong Wang et al, [ 155 ] a bone tumor cell targeting nanosystem was developed for chemophotothermal therapy. The nanosystem incorporated manganese (Mn) and cobalt (Co) ions for nuclear magnetic resonance (NMR) imaging, a bone tumor cell‐targeting peptide (BTTP), and DOX.…”

Section: Applications Of Magnetic Materials In Bone Tissue Engineeringmentioning

confidence: 99%

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Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Carvalho

Torres

Belo

et al. 2023

Advanced NanoBiomed Research

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Diverse applications of nanoparticles (NP) have been revolutionary for various industrial sectors worldwide. In particular, magnetic nanoparticles (MNP) have gained great interest because of their applications in specialized medical areas. This review starts with a brief overview of the magnetic behavior of MNP and a short description of their most used synthesis methods. The second part is dedicated to the MNP applications in tissue engineering, emphasizing the calcium phosphate‐based NP with intrinsic magnetic properties, recently highlighted in the literature as alternative and viable solutions for bone regeneration. The challenges associated with the controversial long‐term toxicity effects of MNP can be overcome using this new generation of multifunctional bone‐like magnetic materials. Furthermore, the influence of magnetic field parameters, such as modality of application, intensity, and spatial distribution, on the biological behavior of magnetic materials, especially for bone repair, is shown. The last part of the review presents the current state of the art regarding the development of magnetic biomaterials for additive manufacturing (AM), aiming to fabricate scaffolds by AM technologies, focusing on bone tissue engineering applications.

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Section: Magnetic Hyperthermia Treatment and Tissue Repairmentioning

confidence: 99%

Section: Calcium Phosphate-based Particles With Intrinsic Magnetic Pr...mentioning

confidence: 99%

Section: Applications Of Magnetic Materials In Bone Tissue Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Carvalho

Torres

Belo

et al. 2023

Advanced NanoBiomed Research

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Bioinspired Tumor‐Targeting and Biomarker‐Activatable Cell‐Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization

Gao

Yang

et al. 2023

Advanced Science

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Osteosarcoma is an aggressive malignant tumor that primarily develops in children and adolescents. The conventional treatments for osteosarcoma often exert negative effects on normal cells, and chemotherapeutic drugs, such as platinum, can lead to multidrug resistance in tumor cells. Herein, this work reports a new bioinspired tumor-targeting and enzyme-activatable cell-material interface system based on DDDEEK-pY-phenylboronic acid (SAP-pY-PBA) conjugates. Using this tandem-activation system, this work selectively regulates the alkaline phosphatase (ALP) triggered anchoring and aggregation of SAP-pY-PBA conjugates on the cancer cell surface and the subsequent formation of the supramolecular hydrogel. This hydrogel layer can efficiently kill osteosarcoma cells by enriching calcium ions from tumor cells and forming a dense hydroxyapatite layer. Owing to the novel antitumor mechanism, this strategy neither hurts normal cells nor causes multidrug resistance in tumor cells, thereby showing an enhanced tumor treatment effect than the classical antitumor drug, doxorubicin (DOX). The outcome of this research demonstrates a new antitumor strategy based on a bioinspired enzyme-responsive biointerface combining supramolecular hydrogels with biomineralization.

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Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment

Zheng,

Meng,

Zhu

et al. 2024

Small

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As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt bone homeostasis. Addressing these disorders requires exogenous strategies to regulate the osteogenic microenvironment (OME). The exogenous regulation of OME can be divided into four processes: induction, modulation, protection, and support, each serving a specific purpose. To this end, metal–organic frameworks (MOFs) are an emerging focus in nanomedicine, which show tremendous potential due to their superior delivery capability. MOFs play numerous roles in OME regulation such as metal ion donors, drug carriers, nanozymes, and photosensitizers, which have been extensively explored in recent studies. This review presents a comprehensive introduction to the exogenous regulation of OME by MOF‐based nanomaterials. By discussing various functional MOF composites, this work aims to inspire and guide the creation of sophisticated and efficient nanomaterials for bone disease management.

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Novel bone tumor cell targeting nanosystem for chemo-photothermal therapy of malignant bone tumors

Cited by 9 publications

References 53 publications

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Bioinspired Tumor‐Targeting and Biomarker‐Activatable Cell‐Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization

Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment

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