Backgrounds: Psoriasis is an autoimmune skin disease that is difficult to cure and easy to relapse after drug withdrawal. Innate macrophage polarization reprogramming has a considerable impact on psoriasis prognosis. Herein, we introduce a method to ameliorate inflammatory responses based on macrophage membrane-engineered extracellular vesicles.
Results: Engineered extracellular vesicles inherited the high stability of M2 macrophage membrane and retained the macrophage reprogramming potential of Annexin A1 overexpressing T cell-derived exosomes. In the psoriasis-like skin mouse model, engineered extracellular vesicles successfully ameliorated inflammatory responses in the skin and spleen with high biosafety.
Conclusions: Our findings indicated that the M2 macrophage-like fusogenic extracellular vesicle-delivery platform had high inflammation-regulating ability and provided new insights and potential strategies for immunotherapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.