Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation

Wang, Zeng; Qin, Zhizhen; Wang, Jiadie; Xu, Xiyan; Zhang, Mengxin; Liang, Yuyue; Huang, Yukun; Yu, Zengyang; Gong, Yu; Zhou, Luxian; Qiu, Yiran; Ma, Minglu; Li, Dan; Li, Bin

doi:10.1080/09546634.2023.2220445

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Accordingly, studies on the circular RNA profile associated with psoriasis identified hsa_circ_0004287 as a candidate for selectively inhibiting macrophage M1 polarization and suppressing imiquimod-induced inflammation in mice [103]. Moreover, engineered EVs produced by fusing the vesicles from annexin A1-overexpressing T lymphocytes with the plasma membranes of M2 macrophages were shown to target macrophages to selectively promote their M2 polarization, which resulted in the alleviation of psoriatic skin inflammation in imiquimod-administered mice [104].…”

Section: Therapeutic Balancing Of the Macrophage Phenotypementioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

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Psoriasis is a systemic autoimmune/autoinflammatory disease that can be well studied in established mouse models. Skin-resident macrophages are classified into epidermal Langerhans cells and dermal macrophages and are involved in innate immunity, orchestration of adaptive immunity, and maintenance of tissue homeostasis due to their ability to constantly shift their phenotype and adapt to the current microenvironment. Consequently, both macrophage populations play dual roles in psoriasis. In some circumstances, pro-inflammatory activated macrophages and Langerhans cells trigger psoriatic inflammation, while in other cases their anti-inflammatory stimulation results in amelioration of the disease. These features make macrophages interesting candidates for modern therapeutic strategies. Owing to the significant progress in knowledge, our review article summarizes current achievements and indicates future research directions to better understand the function of macrophages in psoriasis.

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Section: Therapeutic Balancing Of the Macrophage Phenotypementioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

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Recent advances in extracellular vesicle engineering and its applications to regenerative medicine

Rhim,

Kim,

Lee

et al. 2023

Biomater Res

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Extracellular vesicles (EVs) are nanosized particles that are released from cells and reflect the characteristics of the mother cell. Recently, the EVs have been used in several types of studies across many different fields. In the field of EV research, multiple cell culture and EV isolation techniques have been highlighted in importance. Various strategies, including exclusive component culture media, three-dimensional (3D) cultures, and hypoxic conditions, have been proposed for the cell culture to control function of the EVs. Ultracentrifugation, ultrafiltration, precipitation, and tangential flow filtration (TFF) have been utilized for EV isolation. Although isolated EVs have their own functionalities, several researchers are trying to functionalize EVs by applying various engineering approaches. Gene editing, exogenous, endogenous, and hybridization methods are the four well-known types of EV functionalization strategies. EV engineered through these processes has been applied in the field of regenerative medicine, including kidney diseases, osteoarthritis, rheumatoid arthritis, nervous system-related diseases, and others. In this review, it was focused on engineering approaches for EV functionalization and their applications in regenerative medicine.Graphical Abstract

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Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation

Cited by 2 publications

References 40 publications

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Recent advances in extracellular vesicle engineering and its applications to regenerative medicine

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