The population is expected to increase by 8,5 billion persons in 2030 and 10,9 billion persons in 2100, population is growing at a rate of around 1,1% per year.  One of population growth control by birth control with contraception. The most effective contraception is long-acting contraception, however, on IDHS (Indonesian Health Demographic Survey) only 13% of currently married women use long-acting contraception. Many factors affect contraceptive use among married women, such as knowledge, education, and husband’s support. The purpose of this study was to determine the effect of knowledge, education, and husband's support on the selection of MKJP. This study used meta-analysis with the search engines by Google scholar, PUBMED, science direct, and ProQuest. The study was selected using PRISMA and it was evaluated by AMSTAR. Data synthesis was conducted by STATA 16.0. The results of this study obtained by knowledge [OR = 0,99; 95% Cl : 0,90-1,08, p = 0,000; I2 = 74,8%], education [OR = 0,84; 95% Cl : 0,77-0,92, p = 0,000; I2 = 86,3%], and husband’s [OR = 0,94; 95% Cl : 0,69-1,20, p = 0,000; I2 = 81,5%]. This means that knowledge, education, and husband’s support have an impact on the use of long-acting contraception.

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Bed Occupancy Rate (BOR) is a number that indicates the percentage of the level of use of the bed at a certain time unit in inpatient units. The high achievement of BOR shows that there is an increase in service usage. This condition also shows that the work activities of health workers in the room have also increased. Increased work activities can be the cause of nurses' work fatigue. Fatigue caused by several factors, among others shifts work, individual factors (health or illness, gender, age, education, workload, tenure, marital status and nutritional status). The research aims to analiyze factors influencing working fatigue in nurses at the inpatient unit Idaman Regional Hospital Banjarbaru. This research was an observational analytic study using a crosssectional design with a sample of 56. The research instrument used a questionnaire and the reaction timer application. Dependent variables were work fatigue and the independent variables were age, sex, work shift, work period, marital status and nutritional status. The test used is the Chi-Square test and the Logistic Regression test for multivariate analysis. The results showed that most work fatigues was the tired category by 75%. There was no significant influence between work fatigue and age (p = 0.633), sex (p = 0.642), work shift (p = 0.741) and nutritional status (p = 0.484). There was a significant influence between work fatigue and work period (p = 0.046, Exp B = 5.294) and marital status (p = 0.003, Exp B = 13.927). The most influential factor on work fatigue is marital status (p = 0.003, OR = 13.927). There is an influence between the working period and marital status on work fatigue. There is no influence between age, gender, work shift and nutritional status. The most dominant factor influencing work fatigue is marital status.

Introduction: Diabetoporosis is a very complex health problem in Indonesia. One approach to the problem is through native Indonesian herbal medicine. The application of Scurrula atropurpurea in the treatment of diabetoporosis has not been revealed, so preliminary in silico study needs to be done. Aim: The purpose of the present study was to analyze the interaction between the active compound of Scurrula atropurpurea and the RANKL/RANK/OPG system in the pathomechanism of osteoporosis in diabetes mellitus. Methods: The procedures of the study included the search for the constituent amino acid of the RANK/RANKL/OPG system, the search for the structure of the active component of Scurrula atropurpurea , 3D modeling of protein structure, protein-ligand docking and visualization, and analysis of protein-ligand bonding interactions. Results: Those bond energies were RANKL-aviculin (–274.96 kJ/mol), RANKL-rutin (–263.12 kJ/mol), RANKL-quercitrin (–256.98 kJ/mol), RANKL-quercetin (–226,50 kJ/mol), RANKL-kaempferol (–221,65 kJ/mol), RANKL-catechin (–214,85 kJ/mol), RANKL-epicatechin (–211.66 kJ/mol), RANKL-caffeine (-171.73 kJ/mol), and RANKL-theobromine (-161.14 kJ/mol). The bond energies were RANK-rutin (-719.26 kJ/mol), RANK-catechin (-680.15 kJ/mol), RANK-caffeine (-654.48 kJ/mol), RANK-theobromine (-651.77 kJ/mol), RANK-quercitrin (-650.68 kJ/mol), RANK-kaempferol (-643.03 kJ/mol), RANK-epicatechin (-641.86 kJ/mol), RANK-quercetin (-641.76 kJ/mol), and RANK-aviculin (-628.62 kJ/mol). Those bond energies were OPG-epicatechin (-590.09 kJ/mol), OPG-theobromine (-578.08 kJ/mol), OPG-caffeine (-568.88 kJ/mol), RANKL-catechin (-560.63 kJ/mol), OPG-quercitrin (-554.50 kJ/mol), OPG-rutin (-547.91 kJ/mol), OPG-quercetin (-545.75 kJ/mol), OPG-kaempferol (-544.48 kJ/mol), and OPG-aviculin (-539.15 kJ/mol). Conclusion: The nine active ingredients of Scurrula atropurpurea do not interfere with the physiological function of RANKL to interact with RANK. The initial interaction of RANK with catechin or rutin will facilitate the bond of RANK to RANKL. When forming a complex with OPG, epicatechin will facilitate its interaction with RANKL.

This study aims to analyze the molecular docking between the active compounds of the Garcinia mangostana against the RANKL/RANK/OPG system and its potential as an antiosteoporosis. The research protocol includes the search and modeling of protein and ligand structures and their docking. Software used includes OpenBabel, HEX 8.0, Chimera 1.6.2, Discovery Studio 4.1, LigPlot + and LigandScout 3.1. Tovophillin has the most negative interaction energy with RANKL-OPG (−332.8 Kj/mol) and RANKL-RANK (−298.1 Kj/mol). It was concluded that fourteen active compounds of Garcinia mangostana did not interfere with the physiological function of RANKL against RANK. In addition, the active compound will not affect the RANKL-OPG complex. The antiosteoporosis mechanism of Garcinia mangostana does not by inhibiting RANKL-RANK interactions.