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A series of hydrogels from 2-ethyl-2-oxazoline and three bis(2-oxazoline) crosslinkers-1,4-butylene-2,2 0 -bis(2-oxazoline), 1,6-hexamethylene-2,2 0 -bis(2-oxazoline), and 1,8-octamethylene-2,2 0 -bis(2-oxazoline)-are prepared. The hydrogels differ by the length of aliphatic chain of crosslinker and by the percentage of crosslinker (2-10%). The influence of the type and the percentage of the crosslinker on swelling properties, mechanical properties, and state of water is studied. The equilibrium swelling degree in water ranges from 2 to 20. With a proper selection of the crosslinker, Young's modulus can be varied from 10 kPa to almost 100 kPa. To evaluate the potential for medical applications, the cytotoxicity of extracts and the contact toxicity toward murine fibroblasts are measured. The hydrogels with the crosslinker containing a shorter aliphatic exhibit low toxicity toward fibroblast cells. Moreover, the viability and the proliferation of pancreatic b-cells incubated inside hydrogels for 12 days are analyzed.

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Novel amphiphilic copolymers on the basis of 2-oxazolines containing a free amino group were prepared. The copolymers were synthesized by the living cationic polymerization of 2-ethyl-2-oxazoline (ETOX) and 2-(4-aminophenyl)-2-oxazoline (APOX). The main goal of this work was the synthesis of water soluble polymer material with the defined number of functional groups necessary for the attachment of proteins and polysaccharides. A high concentration of free amino groups allows immobilization of various biosubstances, e.g. drugs, proteins or polysaccharides. Thermal properties have been studied with respect to the composition of the copolymers. Cytotoxicity and the bioimmunological efficiency of the selected copolymer were studied.