Antibiotics delay the development of dietary hepatic necrosis and fibrosis in rats (1,2). This protective effect is lost after the intestinal flora develop resistance to the antibiotic. Furthermore, rats fed a necrogenic diet, but maintained in a germ-free environment, do not develop liver necrosis (2). Clearly, then, bacteria are involved in the development of necrosis or fibrosis. But the way in which bacteria are involved is obscure. Gyorgy (1) believes that the metabolic abnormalities which lead to cirrhosis are enhanced by bacterial activity. At the same time he suggests that antibiotics delay the development of cirrhosis by an undefined protective effect upon the metabolic mechanisms.Experiments were done in this laboratory to explore more precisely the role of the intraintestinal bacteria in the development of cirrhosis in rats. For this objective it was considered necessary to use non-absorbable 1 as well as absorbable antibiotics, in order to distinguish between a systemic effect of antibiotics and their effect upon the intraintestinal flora. In this communication we report the results of the effect of orally administered antibiotics upon rate of growth, survival time, and the pathological changes in the liver of rats on a choline-deficient diet.
MethodMale rats of the Wistar strain, each weighing 95 to 100 gin., were housed in an air-conditioned laboratory in wire cages with raised screen bottoms.
Transfusion for experimental hemorrhagic to transfusion is a result of bacterial activity, shock of 2 hours duration is followed by re-which cannot be controlled because shock covery. But if the shock is allowed to persist produces a progressively Severe injury to the for much longer (4-5 hours) it fails to re-antibacterial mechanisms( 1-6). The further spond to transfusion. Evidence has been given observation that intravenous antibiotic therthat the failure of the circulation to respond apy, give11 shortly after shock was induced, bility, in contrast to the Success of !XIch there 4 Supported by contract with oftice of Surgeon failed to prevent the development of irreversiapy when given before shock was induced General, U. S. Army, and by research grant from SIH.
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