Macro creatine kinase type 2 in human colonic tissues

Creatine kinase isoenzymes activity in serum and buccal pouch tissue of hamsters during DMBA‐induced squamous cell carcinogenesis

“…in serum and colonic tissue, was reported by RoGALSKY et al (42), who also suggested that there were still other unknovvn mechanisms affecting the re-lease of MCK-2 into the circulatory system.…”

“…The cytoplasmic CK isoenzymes, namely, CK-MM (muscle type), CK-MB (myocardial type) and CK-BB (brain type), are composed of the diiner of two immunologically distinct M (muscle) and B (brain) polypeptide subunits (3,4), which are so called because they have been isolated from skeletal muscle and brain tissue respectively (5). However, there are many reports of atypical forms of CK termed macro CK (6,(21)(22)(23)(24)(25)(26)(27)(28)42). These include macro CK type 1, identified as CK-BB linked to IgG, which, during electrophoresis, migrates between the CK-MM and CK-MB bands (2) and macro CK type 2 (MCK-2), which is an aggregate of mitochondria!…”

Apparent Elevation of Serum Ck‐mb Not Due to Acute Myocardial Infarction

“…2 Macro CK is significantly associated with malignancy, particularly colonic carcinoma, and may be valuable as a tissue marker. 3 Although our patient with prostatic carcinoma may possibly have had myocardial damage, as there was a fall in the initial high levels of CK-MB, the inappropriate levels relative to total CK prompted serum electrophoresis for other CK isoenzymes.…”

“…Subsequently two types of ‘macro CK’ have been described: type 1, usually a complex of cytoplasm CK‐BB and serum IgG, and type 2, an oligomeric complex released from mitochondria during high cell turnover or tissue damage 2 . Macro CK is significantly associated with malignancy, particularly colonic carcinoma, and may be valuable as a tissue marker 3 …”